In addition, scientists have observed that those who supplemented with IGF-1 experienced a preponderance of new brain cell growth and new muscle mass and new studies confirmed this to be true, even among individuals with both brain damage and muscle-wasting sarcopenia. Furthermore, research studies have found IGF-1 to increase feelings of youthfulness, improve well-being, and even to alleviate depression.
In vitro studies by Metabolic Collaborators showed that AOD9604 enhances the differentiation of adipose mesenchymal stem cells into bone, promotes proteoglycan and collagen production in isolated bovine chondrocytes, and promotes differentiation of myoblasts into C2C12 cells. These effects induced by AOD9604 are similar to those required for the repair of bone, cartilage, and muscle, all of which are affected in OA. To the best of our knowledge, no study has compared the effects of GH and HA intra-articular injections on OA. A previous study showed the effects of intra-articular GH injection on articulophyseal cartilage regeneration in the knees of rabbits [9]. Our study showed that the groups that received AOD9604 or HA injection had better outcomes in terms of morphological and histolopathological findings, as well as a lowered duration of lameness than the group that received saline injections, although there are no significant differences between the two groups. In addition, our study revealed that the groups that received combined injections of AOD9604 and HA showed better outcomes than the groups that received AOD9604 or HA alone. The apparently synergistic effect of combined injections is thought to indicate that intra-articular injection of HA may have a chondrocyte-protective role, and the AOD9604 could help recapitulate the developmental cascades which regrows a segment of the articular cartilage in a joint. Our results are consistent with those of a previous study [8] that combined the injection of HA with recombinant human GH and found that the combination is more effective than HA injection alone.
Not every peptide will suite every individual and it may take some experimenting to get the right peptide and dose. Our recent article explains more about who peptides will work for. So what is the best peptide for fat loss and is there any one type that will almost guarantee some success? The answer is NO! Everyone is different and to repeat what was said above, experimenting is vital for success.

You can add CJC-1295 DAC at 2mg once per week (or 300mcg each day along with your HGH Frag 176-191 injections - they can be mixed in the same syringe without any issues). You should take a break from CJC-1295 DAC every few months to give your pituitary gland a rest at which time you can continue to use HGH Frag 176-191 on its own, or you can substitute the CJC-1295 DAC with the short acting Modified GRF 1-29 at 100-300mcg per day (split into injections of 100mcg).
In the 80 years, scientists have searched different peptides and more particularly GHRH to discern what part was necessary to stimulate the pituitary response. Then in testing Sermorelin as a tool for the process of anti-agingthey found that it was the famous 1-29 chain that was responsible for stimulating the endocrine gland in question. Similarly, many studies have shown that this peptide was similar to GHRH and very well tolerated by the body.
AOD9604 is a new synthetic peptide fragment that comprises a modified 15 amino acid region of GH with a tyrosine component to help stabilize the molecule. Similar to GH, AOD9604 aids weight reduction in rodent models of obesity and was originally developed for the treatment of obesity in humans [11]. Additionally, it does not stimulate the production of IGF-1 [10], has positive effects on the differentiation of adipose mesenchymal stem cells into bone, and was found to promote proteoglycan and collagen production in isolated bovine chondrocytes in an in vitro study by Metabolic Pharmaceuticals (patent applied [WO2013082667]). Its positive effects include promoting the repair of bone and cartilage in cases of OA.
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WT (n = 9) and β3-KO (n = 9) mice were used in this study. Animals were fasted 2 h before being individually placed in an indirect calorimeter. Calorimetry was performed as in previous studies (8). After baseline readings were taken, mice were injected with one of the following compounds: saline (control; n = 3); AOD9604 (2 mg/kg body weight; n = 3); or BRL37344 (250 μg/kg body weight; n = 3). Rates of energy expenditure, fat oxidation, and glucose oxidation were measured for an additional 30 min. The concentrations of AOD9604 and BRL37344 were determined as lowest concentration needed to give a maximal response in these mice (data not shown). Rates of energy expenditure and fat and glucose oxidation were plotted as a change from the average baseline values.

Peptides are not to be confused with synthetic human growth hormone drugs, which are injected into the bloodstream to provide rapid results. HGH is said to be Hollywood's secret weapon, with top stars, filmmakers and studio execs hooked on the youthful effects, but synthetic hGH is tightly regulated in Australia and verboten unless there's a proven growth hormone deficiency (most cases are in children).
AOD9604, a synthetic fragment of hGH consisting of the amino acid residues 177–191 with the addition of a tyrosine residue to the N-terminus was prepared with solid-phase synthesis procedure and purified with reverse-phase HPLC methodology in our laboratories (13). The structure of the peptide analog was verified with mass spectrometry and amino acid analysis. The hGH was a gift of Professor Michael Waters (University of Queensland, Brisbane, Australia). BRL37344 (β3-AR agonist) was a gift from Dr. Jon Arch (SmithKline Beecham, Harlow, UK).
The company which developed it, Metabolic Pharmaceuticals, did have a small early study done which showed a small amount of fat loss at 1 mg per day but not really any other dosing. Measured effect was less at higher doses. In total the company did at least six studies. According to the lead researcher of five of the studies, Dr Gary Wittert, results were uniformly negative.

As it is not yet approved for use in this country (or any other), it should always have been considered banned under the S0 category, which states that any pharmacological substance that is not addressed by any of the subsequent sections of the Prohibited List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited.


To buy our premium peptides online you will need to complete a simple online medical questionnaire. This is a legal requirement due to the regulation of Peptides in Australia. We cannot legally advertise specific Peptides to the general public without first ascertaining you are over 18 years of age and have submitted the required medical questionnaire. Learn more about Muscle Peptides Australia services.
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