This is cutting edge science and i freely admit is a could argue whey, bcaa or even intermittent fasting does the same thing, just not as refined hence the argument and confusion is that the substance is grey because the peptide stimulates natural GH which not even wada or asada know how to pidgeon hole it....its mostly unclassified...this is why we will be just fine... are you starting to see the glaring holes in your facts yet?
The evidence so far suggests that there may be some effect on cartilage and bone densities, and it is correlated with weight loss. I understand that there is no evidence to suggest that it stimulates the release of IGF-1, which is the mechanism via which growth hormone gets most of its purported performance enhancing effects (i.e. muscle bulk). Whilst this is a decent list of things to test if one is considering AOD9604 as simply a variant of growth hormone, it is by no means exhaustive of all the mechanisms via which a drug can enhance athletic performance. The evidence thus far suggests that AOD9604 could be performance enhancing, but there is nothing I would hang my hat on. That is why I maintain that Dank is more sorcerer than scientist.
Another way GH helps with fat loss is that it maintains blood glucose levels by inhibiting glucose uptake into peripheral cells, decreasing glucose oxidation for energy in the cells, and therefore increasing glucose production in cells from fat and amino acids (gluconeogenesis) (Copeland 1994, Ho 1996). The free fatty acids in the blood from lipolysis also partially block the insulin receptors on cell membranes, decreasing the effectiveness of insulin in triggering the removal of glucose from the blood, causing insulin resistance, or decreased insulin sensitivity. These all result in fat loss, especially from hard to move intra-abdominal fat stores (Johannsson 1997).

The consumption of all dairy products have been shown to naturally raise IGF-1 levels , but I personally go straight to the source and both drink camel milk and other forms of raw milk (in moderation) and use goat’s milk colostrum. In scientific studies, colostrum supplements have proven to increase the amount of IGF-1 and IgA in the bloodstream (IgA is an important immunoglobulin that helps to ensure our immunity to pathogens, especially in the mucous membranes).
Background: The human growth hormone (hGH) has properties making it a potential candidate to treat obesity, however safety issues limit its long-term use. AOD9604 is a peptide fragment of the C-terminus of hGH (Tyr-hGH177-191), which harbors the fat reducing activity of hGH, without its negative effects. In this paper the safety data of AOD9604 obtained in clinical trials are summarized.
In a statement to Fairfax Media on Thursday, Calzada Ltd said: ''The US generally recognised as safe 'GRAS' status is being explored as another viable commercial path for the company to pursue to potentially derive early revenue. Whilst AOD-9604 was not successful in human trials aimed at obesity, the Company believes there is sufficient efficacy data to enable a potential food, drink or dietary supplement product to be successfully marketed in the US.''
We identified 34 patients who met eligibility criteria based on the chart review. Two subjects were excluded because they were found to have diabetes requiring insulin therapy, 1 was excluded because of hypothyroidism, and 13 were excluded because they did not undergo gastric bypass surgery or did not wish to participate. A final study sample of 18 individuals (15 women) was enrolled into the protocol. We had 3 individuals who did not complete the 6‐month follow‐up visit; the sample that completed both visits consisted of 15 individuals (12 women). No subjects were excluded because of peri‐operative complications. Table 1 displays the characteristics of the study sample at baseline and 6 months after surgery. From baseline to 6 months after surgery, subjects had a mean decrease of 27% in body mass index (P<0.0001). There were significant reductions in mean arterial blood pressure (P=0.004) and heart rate (P<0.001) after surgery. Only 2 out of 18 subjects were on any class of anti‐hypertensive medications at the pre‐op visit before gastric bypass surgery. At the 6‐month visit, anti‐hypertensive medication was discontinued for one of these subjects, and continued at the same dose for the other subject. The mean±SD volume of saline infusion pre‐bypass was 2.6±0.4 L and post‐bypass was 2.3±0.3 L.
All studies were performed as double-blind placebo-controlled trials with specific design adaption depending on the question that was to be answered. All, but the first, were performed on obese, but otherwise healthy, adults. In the first 4 studies, only male subjects were included (supplementary data). Approximately 900 adult subjects participated in these 6 clinical trials.
Ipamorelin, like other growth hormone peptides, is used to increase production of your own growth hormone levels. Growth hormone levels are at their peak in our twenties, and then gradually decrease with age. There are a few different peptides including Sermorelin, GHRP2, GHRP6, and Ipamorelin. These peptides are listed in order of how recently they have been developed, with Ipamorelin being the newest and most commonly recommended.
The effects of hGH and AOD9604 on fat metabolism may be mediated by an alteration in the expression of a lipolytic/antilipogenic gene. Theβ 3-AR is a major lipolytic receptor identified in rodent fat cells (18) that mediates its effects through G protein coupling to adenylate cyclase, generation of cAMP, and stimulation of PKA (19). This enzyme then phosphorylates proteins in the lipolytic cascade, including hormone-sensitive lipase (20). In BAT, the β3-AR stimulates uncoupling of the electron transport chain, enhancing the ability of mitochondria to generate heat in preference to ATP through the dissipation of the electron gradient (21). Mice that lack this receptor have lower rates of resting energy expenditure (0.0041 vs. 0.0047 kcal/min, P < 0.02) and lower rates of fat oxidation (0.00019 vs. 0.00030 g/min, P < 0.02) than control mice (data not shown).
Tissues from ob/ob and lean mice were cut into 100-mg pieces and homogenized with 1 ml TRIzol (Life Technologies, Inc., Grand Island, NY) using a PolyTron homogenizer (Kinematica, Lausanne, Switzerland). The samples were incubated for 5 min at room temperature to permit the complete extraction of the RNA from the tissues. An aliquot of 0.2 ml chloroform was added to each milliliter of TRIzol. The method of RNA extraction was as described by the manufacturer (Life Technologies, Inc.). The final RNA pellet was air dried for 5–10 min and then resuspended in 20 μl ddH20. RNA was quantitated spectrophotometrically using the A260/280 ratio.
Abellan R, Ventura R, Palmi I, di Carlo S, Bacosi A, Bellver M, Olive R, Pascual JA, Pacifici R, Segura J, Zuccaro P, Pichini S. Immunoassays for the measurement of IGF-II, IGFBP-2 and -3, and ICTP as indirect biomarkers of recombinant human growth hormone misuse in sport. Values in selected population of athletes. J Pharm Biomed Anal. 2008 Nov 4;48(3):844-52. doi: 10.1016/j.jpba.2008.05.037.
CJC-1295 is a fast-acting Growth Hormone Releasing Hormone designed to enhance the body’s natural production and release of human growth hormone and Insulin-like Growth Factor 1 (IGF-1). In doing so, CJC-1295 reverses the age-related decline, generates new muscle cells and increases fat loss. Another great trait of CJC-1295 is its ability to promote slow wave sleep, a deep sleep responsible for the highest levels of cell regeneration, muscle growth and memory retention.

One more way for growth hormone to help with fat loss is that this sustains the levels of blood glucose through inhibiting glucose uptake to the peripheral cells, reducing the glucose oxidation for the energy in cells and thus boosting the production of the glucose in the cells from amino acids and fats. The blood’s free fatty acids from lipolysis also partially obstruct the insulin receptors on the cell membranes, reducing insulin’s effectiveness in triggering glucose removal from the blood that causes decreased sensitivity to insulin or insulin resistance. These will then result to fat loss, particularly from the difficult to move intra-abdominal storages of fat.

Design Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint. Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4–7 weeks after the first intra-articular collagenase injection. The degree of cartilage degeneration was assessed using morphological and histopathological findings, and the degree of lameness was observed at 8 weeks after the first collagenase injection.
AOD9604, a synthetic fragment of hGH consisting of the amino acid residues 177–191 with the addition of a tyrosine residue to the N-terminus was prepared with solid-phase synthesis procedure and purified with reverse-phase HPLC methodology in our laboratories (13). The structure of the peptide analog was verified with mass spectrometry and amino acid analysis. The hGH was a gift of Professor Michael Waters (University of Queensland, Brisbane, Australia). BRL37344 (β3-AR agonist) was a gift from Dr. Jon Arch (SmithKline Beecham, Harlow, UK).
Although growth hormone and growth hormone releasing hormones are classified as prescription drugs, there is a safe and legal way to increase your levels of hGH production. There are a range of growth hormone supplements designed to boost hGH production within normal limits. For more information, please refer to our “Natural Growth Hormone Supplements Guide”.
Paracetamol is distinct from non-steroidal anti-inflammatory drugs (NSAIDs). It is a para-acetylaminophenol with both analgesic and antipyretic properties. Originally synthesized in the 1880s and first released for use on prescription in 1955 in the USA and on 1956 in UK. It has been available in most countries, without prescription, for many years. Recent data suggests it acts via a central mechanism, whereby it is deacetylated to 4-aminophenyl and then conjugated with arachidonic acid to form N-arachidonoylphenylamine which is an exogenous cannabinoid (Hogestatt ED et al. 2005).

Background: The human growth hormone (hGH) has properties making it a potential candidate to treat obesity, however safety issues limit its long-term use. AOD9604 is a peptide fragment of the C-terminus of hGH (Tyr-hGH177-191), which harbors the fat reducing activity of hGH, without its negative effects. In this paper the safety data of AOD9604 obtained in clinical trials are summarized.

CJC 1295 is a fast working growth hormone releasing hormones devised to reduce the effects of ageing. It works by stimulating the body’s natural growth hormone production and the release of IGF-1. The advantages of the CJC peptide is it helps increases bone density and collagen, as well as boosting the immune system. It will also produce new muscle cells which will be leaner and increases weight loss. The CJC 1295 results are part of years of scientific studies. It primarily increases the production of proteins, which leads to stable bodily functions related to the glands in the body or the endocrine system.

The DAC technology in the CJC-1295 enables the compound to bind itself covalently with any circulating albumin, after it has been administered through a subcutaneous injection. However, the reason why the half-life could be extended from a few minutes to several days is more profound. The reactive group in the CJC-1295 binds to a peptide through bioconjugation. The peptide then finds a neucleophilic unit within the blood and reacts with it in order to create a firmer bond.

Within all the clinical trials the subjects received either the active treatment AOD9604 Tyr-hGH177-191(Metabolic Pharmaceuticals Ltd.; amino acid sequence: YLRIVQCRSVEGSCGF; CAS Registry Number: 38624-39-7; INCI Name: 27701 sh-Oligopeptide-74) or placebo (vehicle of mix of excipients). In addition, in study METAOD001 individual subjects were treated with rhHG (0.12 IU/kg; supplied by Unichem in the form of somatropin (Saizen® - Serono)) as a positive control. The administered doses of the study product ranged from 25 µg up to 400 µg per kg bodyweight for the injectable product (i.v. administration in study METAOD001 and METAOD002) and from 0.25 mg/day to 54 mg/day for the orally administered capsules/tablets (capsules METAOD003 - METAOD005; tablets: METAOD006).
I was keen to try out CJC 1295 because my gym buddies had been using it for a while with fast and positive results. Though I was a bit nervous about injecting myself! To my surprise, it was easier than I expected. So I ordered online with Peptides Clinics and received a fast and efficient service. Everything came packaged in ice packs and with relevant info. Initially, I tried with the lowest dosage of CJC-1295 which was 10 mg for 10 weeks. It wasn’t look before I was seeing results. In fact, I noticed pretty quickly an increase in lean muscle, and couldn’t believe the amount of weight I lost! Brilliant! But, I have been advised to try out the CJC 1295 Ipamorelin combination, which I will do soon!

In the first dose-escalating study (METAOD001) 15 healthy male subjects received 3 single dosages of AOD9604 and placebo as single dosages each separated by a 7-day washout period (range 25 to 400 µg/kg bodyweight; single IV infusion doses over 20 minutes). One subject terminated the study due to personal reasons, 14 subjects completed the study. In total twenty-nine AEs were reported by twelve subjects during the study. No SAEs occurred during this study. The most common AEs reported during the study were headache (6 times). The remainder were related to fatigue (4), hypoglycemia unspecified (3), dizziness (3), nasopharyngitis (2), cough (2) and lethargy, tonsillitis, abdominal pain unspecified, application site reaction unspecified, sore throat unspecified, injection site bruising, rhinitis seasonal, anorexia, injection site pain, all with an incidence of 1. None of the AEs were of severe intensity. The majority of AEs were mild in intensity with possible relationship to study treatment, equally distributed between the various concentrations of AOD9604 and placebo treatment. The adverse event profile was similar following administration of all treatments.
In our study, the rapid recovery from lameness (11 days) in the group that received AOD9604 and HA injection suggests that an early anti-inflammatory and pain-relieving effect could be induced before the tissue repair observed at the end of the treatment period (35 days). This result may be explained by the pain-relieving effects of GH [30]. The intra-articular injection to the human knee using ultrasound guidance notably enhances the accuracy compared with injection using anatomical guidance [31–33]. Until recently, intra-articular injections to the rabbit knee using ultrasound guidance have rarely been reported [34]. In our study, intra-articular injections were performed using ultrasound guidance to identify the correct trajectory for needle placement in the knee joint, as the rabbit knee joint is smaller than that of humans.
There are thousands of weight loss programs to choose from. A Google search for how to lose weight returns over 97 million results. With so much information out there, it’s easy to get overwhelmed or confused. Especially since most of the information you come across on weight loss is completely false. There are gimmicks and bad advice that lead desperate dieters down the wrong path, and the only measurable result is the decrease in the weight of your wallet!
Time line of collagenase, saline, HA and AOD9604 injection. Collagenase (0.25 mg) was injected in right knee twice on day 1 and 4, respectively. Normal saline 0.6 ml (group 1), HA 6 mg (group 2), AOD9604 0.25 mg (group 3), and AOD9604 0.25mg with HA 6 mg (group 4) were injected in the right knee at 4 weeks after the first collagenase injection. All rabbits were euthanized by CO inhalation at 4 weeks after injection of 4 different solutions.
Colostrum: The very early form of milk secreted late in pregnancy and in the first few days after birth, colostrum contains a complex mixture of nutrients, antibodies (to build immunity) and growth factors (to stimulate gut development) which are important to a newborn’s health and development, though its effects in adults are less clear. There’s little evidence that colostrum consumption (typically cow colostrum) improves the immune status of athletes. While not directly banned, colostrum could stimulate Insulin-Like Growth Factor-1 (IGF-1) secretion. IGF-1 is banned, but stimulation of its secretion by nutritional supplements is a grey area.
This peptide is a modified fragment of hGH which contains the portion of the molecule that is believed to be responsible for hGH’s anti-obesity effects. The peptide has been shown to increase fat burning without the increase in blood sugar and growth rate that has been seen with hGH itself. AOD 9604 has been deemed safe for chronic use by the FDA, receiving Human GRAS status in 2014. In addition to its utility as an anti-obesity peptide, AOD 9604 has been shown to have very favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157.
However, after the administration, Mod GRF 1-29 starts breaking down soon. This happens because peptides have a strong affinity for bonding with amino acids. The administered peptide has to travel a long distance between the point of administration and the pituitary gland. On the way, the enzymes act on it making it break down and bond with the amino acids. The peptides that are secreted by the body on its own do not have to face this problem because they do not have to travel this long.
Male New Zealand white rabbits (n=32; aged 12 weeks) were used in the experiments. Animals were housed in separate metal cages at a temperature of 23°C±2°C and relative humidity of 45%±10%. The animals were allowed free access to tap water and were fed a commercial rabbit diet. Animal experiments were performed in accordance with internationally accredited guidelines and approved by laboratory’s Institutional Animal Care and Use Committee.
In this study, plasma glycerol was also assayed as a measure of lipolytic rate. As shown in Fig. 5C, both AOD9604 and hGH increased glycerol levels following treatment in the WT mice, indicative of enhanced lipolysis. In the β3-KO mouse, however, no effect was observed with AOD9604. A significant increase in plasma glycerol from controls was observed following hGH treatment, but this was markedly less than that observed in the WT mouse. These data indicate the importance of β3-AR in the lipolytic response to AOD9604 in these animals and the necessity of the receptor for the chronic effectiveness of AOD9604 and hGH on fat reduction.
With a blend of peptide and GH supplements, Ipamorelin can greatly help you in your weight loss endeavours. Using it with IGF-1 which is a natural growth hormone, can help you achieve even greater results. With lower dosage, you won’t increase muscle mass, your body will naturally decrease body fat levels, and you will begin to metabolize food faster, meaning you burn more calories in less time, for greater weight loss results.
Our hormone levels decline as we age, and therefore the effects of these hormones decline proportionally. Even if you exercise and eat well, you will still experience this decline in hormone production and all of the associated adverse health effects that this brings. To fight ageing, and increase vitality, we can restore our hormones to their youthful levels.
Collagen is also supposed to help with joint pain. Although I (luckily) don’t have chronic pain in my joints, my knees do flare up from time to time ever since I ran a half marathon a couple years ago. I also get some soreness in what feels like the bones in my legs a couple times a week, usually after a run or intense cardio session. If drinking collagen would ease this pain, then I was game.
I know so... you demonstrate a severe lack of knowledge of how the compound works which is kinda funny that you came here to big note your self about facts... i agree the substance is grey area PE but your attempt at a cheap shot to sound all informed is flat out wrong... its the crux of the argument as to why everyone is so confused... you have made a complete fool out of your self trying to sound all smart and stuff...
Male New Zealand white rabbits (n=32; aged 12 weeks) were used in the experiments. Animals were housed in separate metal cages at a temperature of 23°C±2°C and relative humidity of 45%±10%. The animals were allowed free access to tap water and were fed a commercial rabbit diet. Animal experiments were performed in accordance with internationally accredited guidelines and approved by laboratory’s Institutional Animal Care and Use Committee.
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used in the management of mild to moderate pain and inflammation in conditions such as dysmenorrhoea, headache including migraine, post-operative pain, dental pain, musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis including juvenile idiopathic arthritis, peri-articular disorders such as bursitis and tenosynovitis, and soft tissue disorders such as sprains and strains. It is also used to reduce fever.
No need to visit a physical peptide clinic, Muscle Peptide Australia can ship throughout Australia: to Sydney, Melbourne, Brisbane, Perth, Adelaide, Darwin, Hobart and regional areas. There’s no time like now to begin this journey. Customers can order from our convenient and user-friendly website to get the supplements they need. Send us an e-mail, and our customer service team will be happy to address any questions or concerns you may have. We specialize in offering an affordable and efficient way to stay healthy for good.