Figure 2. A, Concentrations of plasma mature BNP levels at baseline and at 40, 80, 120, and 180 minutes after the start of saline infusion. Solid line with squares represents pre‐bypass surgery subjects and dotted line with triangles represents post‐bypass surgery subjects. B, Concentrations of plasma Nt‐proBNP levels at baseline and at 40, 80, 120, and 180 minutes after the start of saline infusion. Solid line with squares represents pre‐bypass surgery subjects and dotted line with triangles represents post‐bypass surgery subjects. BNP indicates B‐type natriuretic peptide; Nt‐proBNP, N‐terminal pro‐BNP.
Echocardiographic measurements obtained at pre‐ and post‐bypass visits are outlined in Table 2. Due to limitations in scanning windows and poor image quality, interpretable echocardiograms were obtained in 12 of 15 patients. Transmitral E increased from 76±19 cm/s at pre‐bypass to 83±19 cm/s at the post‐bypass surgery visit while no significant increase was noted in transmitral A. The mean intra‐individual change in transmitral E was 15 cm/s, with 95% confidence interval 3 to 26 cm/s. The increases in transmitral E were significant for the effects of saline (P=0.005) and surgery (P=0.002). There was also a significant increase in the early diastolic mitral annular velocity e′ (P=0.02 for effect of surgery). However, the E/e′ ratio did not change after surgery (Table 2). Left atrial diameter showed a trend towards decrease at the post‐bypass surgery visit (P=0.3).
Another benefit of CJC 1295 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS decreases significantly in older adults and also with people who tend to exercise later in the evening. Clinical studies have shown that a once-daily administration of CJC 1295 normalizes the GHRH response and can induce significantly deeper sleep.
Recent advances in the field of regenerative medicine, such as the use of platelet-rich plasma and stem cell injections, are emerging as the preferred options for treating OA. This is in part because patients do not desire only temporary alleviation of symptoms. Rather, patients also seek permanent correction and repair of the underlying biology for regenerating the damaged tissue in order to permanently alleviate their symptoms [4]. The aforementioned treatment options have been used in several areas of medicine for delivering growth factors to optimize healing.
Yes, Ipamorelin can help you lose weight. But, if you are not exercising, and aren’t eating well, it can only do so much. There is no magical supplement which will undo laziness and a horrible diet – keep this in mind. When using it for fat loss, make sure you are exercising. Doing so will naturally increase weight loss results, as you are going to burn more calories, along with the caloric deficit you are already on, for greater results. Further, your diet matters. If you are eating 5000 calories of junk per day, no supplement will help you lose weight – no matter how potent it claims to be!
Osteoarthritis (OA) is a degenerative joint disease that results from articular cartilage loss induced by complex interactions of genetic, metabolic, biochemical, and biomechanical factors with secondary components of inflammation [1]. OA is the most common arthritis and a major medical problem in people aged 65 years and older [2]. Non-steroidal anti-inflammatory drugs (NSAIDs), physical therapy, exercises, corticosteroids, and hyaluronic acid injections have all been used for the conservative treatment of OA. The role of NSAIDs in OA management is controversial because of its adverse side effects, as well as side effects on the cartilage [3].
Then there’s colostrum. Colostrum is packed with growth factors, including IGF-1, that amplify lean muscle gains and increase the body’s ability to burn fat. In many studies, colostrum has been shown to restore IGF-1 and stimulate IGF-1 production. Colostrum is also a natural immunity drug, containing antibodies and antigens that knock out disease-causing agents such as bacteria, viruses, and fungi.
Recent advances in the field of regenerative medicine, such as the use of platelet-rich plasma and stem cell injections, are emerging as the preferred options for treating OA. This is in part because patients do not desire only temporary alleviation of symptoms. Rather, patients also seek permanent correction and repair of the underlying biology for regenerating the damaged tissue in order to permanently alleviate their symptoms [4]. The aforementioned treatment options have been used in several areas of medicine for delivering growth factors to optimize healing.
Subjects were excluded if they had any of the following: history of myocardial infarction, heart failure, or left ventricular (LV) ejection fraction <50%, greater than mild valvular stenosis or regurgitation or any regional wall motion abnormalities by cardiac imaging, chronic renal failure or serum creatinine ≥3.0 mg/dL, atrial fibrillation, diabetes mellitus requiring insulin therapy, systolic blood pressure ≥170 mm Hg or diastolic blood pressure ≥100 mm Hg at the most recent weight center visit, a history of current loop or thiazide diuretic use, a history of obstructive lung disease, or thyroid dysfunction. Female subjects who were pregnant or planned to become pregnant within 6 months were also excluded. The Partners Human Research Committee approved the protocol. All subjects provided informed consent.
This is a great option for those who are looking to promote a steady and improved release of GH to get the benefits of increases in growth hormone and subsequently Insulin Like Growth Factor -1 (IGF-1) with almost no side effects. This therapy is effectively used for anti-aging purposes as well as those with inflammatory conditions, disease or those who have low IGF-1 levels.
The simple science of amino acids linked together, via peptide bonds, brings to life this now common word – “Peptides”. Used for a variety of health, fitness and anti ageing concerns, Peptides can help in many ways to promote fat loss, build lean muscle, assist with injury recovery, increase agility, and many other anti ageing benefits. Peptides are amino acid chains that act as messengers in the cellular world by telling your cells what to do. One of the world’s best kept secrets for optimal health is Human Growth Hormone (HGH). HGH is so instrumentally important that its decline as we age is directly related to our health and quality of life. Modern medicine is now recognising its decrease as a clinical syndrome called “Growth Hormone Deficiency Syndrome”. By stimulating your Growth Hormone levels back to a level that is clinically predicted for your age will allow your body to perform at its peak which allows you to feel youthful and rejuvenated.
GH levels decrease significantly as one ages. By the time you are 30 years old the endocrine system is no longer functioning optimally, thus the hormones that typically helped us stay lean, are secreting at a much lower level. The result of this is stubborn fat storage, which favours the abdominal region. Visceral fat in particular is a very common plight in middle age.

Colostrum: The very early form of milk secreted late in pregnancy and in the first few days after birth, colostrum contains a complex mixture of nutrients, antibodies (to build immunity) and growth factors (to stimulate gut development) which are important to a newborn’s health and development, though its effects in adults are less clear. There’s little evidence that colostrum consumption (typically cow colostrum) improves the immune status of athletes. While not directly banned, colostrum could stimulate Insulin-Like Growth Factor-1 (IGF-1) secretion. IGF-1 is banned, but stimulation of its secretion by nutritional supplements is a grey area.
For those who are just getting started, make sure you go gradually. Start off with an eight-week cycle, and start off with 200 mcg (rather than 300) per day. Doing a test run will allow you to see how your body is going to react. If all goes well, you can then increase your dosage cycle to an 8 to 12 week period, and possibly add an additional injection dose daily, or increase to 300 mcg with each use.

Background: The human growth hormone (hGH) has fat loss properties making it a potential candidate to treat obesity. AOD 9604 is a peptide fragment of the C-terminus of hGH (Tyr-hGH177-191), which harbors the fat reducing activity of hGH, without its negative effects. In this paper the safety data of AOD 9604 obtained in clinical trials are summarized.


In no particular order of importance, here they are: I swallow colostrum capsules every morning, I drink raw animal milk such as camel milk and goat milk in moderation, and I use the equivalent of around 30 grams of grass-fed whey protein each day in a smoothie (if you’re vegan or if whey protein doesn’t agree with your stomach, you can combine digestive enzymes with a vegan protein such as brown rice protein, pea protein or hemp protein for an effect similar to whey protein).
I'm new to the forum and there is some great information here that I need to do more reading on. I've been taking Ipam and ModGrf 1-29 for at least 2yrs now. The first thing I noticed is that I have good quality sleep. I have difficulty sleeping and staying asleep. I take these peps 20min before I go to bed and get a good deep sleep for at least most of the night. I take them before doing my morning cardio, after my workout (afternoon) and before I go to bed. I've read if you take it before your morning cardio it releases more FFA to burn during your session. After the workout to aid in recovery. Before bed to aid in a deeper sleep. It is important when you take them. Dont eat before morning cardio...no carbs/sugary drinks...3hrs should have passed before taking another shot and do not eat before 15-20min after taking the peps. The reason (I've read) to wait these times is to take them while your insulin levels are low. High Insulin levels will minimize the pulsation of the GH. The phrase I've read is to try to keep "insulin quiet" to maximize the pulse of GH. Ipam can work by itself but if taken with ModGrf 1-29 it will magnify the GH Pulse. ModGrf is useless by itself. I've read that there is a saturation dose, so more is not better. 200mcg for each should do the job. Since synthetic GH shuts down natural production, these peps stimulate the pituitary to pulse more natural GH. To get the maximum effect of syn GH, you would also take the shot at the same time discussed above. Once again, this is what I've read and the protocol that I've followed. The results arent like AAS (nothing is!) but it is a good way to feel better since I cant take TRT. (trying to have kids) I also travel with the peps bc I value the sleep that I get from it.

Just as you could eat more calories than you think if you aren’t keeping track, you might miss some positive results of your efforts if you aren’t tracking your progress. Weigh yourself weekly. Take body measurements of your waist, legs, chest, and arms every other week. Measure your body fat percentage. Take photos of yourself once a month. Sometimes the scale won’t show results from week to week, but if you have all of the other methods of tracking in place, you’ll be able to see your efforts are being rewarded.
CJC-1295 is basically a peptide hormone that acts similar to growth hormone releasing hormones (GHRH). Invented by a Canadian biotechnology company called ConjuChem, it is beneficial to athletes because it can bioconjugate with circulating albumin and increase the time it can be used for medical purposes. It achieves this by preventing degradation of its amino acids. With a single dose, it can remain in the body for quite a few days and can cause the growth hormone to be released many times per day. This reduces the frequency of injections needed.
It has to be noted that three of the SAEs were skin cancer forms. Since the study was performed in Australia, a country with the highest incidence rate of skin cancer (http://globocan.iarc.fr/), this cumulative incidence is not improbable. Furthermore the study was performed on clinically obese subjects with a BMI ≥ 35 kg/m2 (BMI ≥ 35 kg/m2; Median BMI: 40 kg/m2, range: 35 to 67 kg/m2). It is known that the incidence of several types of cancers is associated with increased BMI [26].
In plasma, different isoforms and fragments of hGH were found [10]. Research on specific domains and fractions of the protein revealed that they can be assigned to different actions of the protein: In vitro and in vivo experiments have shown that several fragments of the amino terminal region of hGH, namely 1-15, 1-42, 6-13, and 32-46, exhibit an insulin-potentiating action [14-16]. The region hGH 108-129 was found to evoke high mitogenic responses [17], while the carboxy terminus hGH177-191 seemed to be a lipid mobilizing domain, inhibiting the acetyl-CoA carboxylase activity in adipocytes and hepatocytes [18].

CJC 1295 has shown some amazing results as a growth hormone releasing hormone (GHRH) analog. Not only has CJC 1295 shown potential to increase growth hormone and IGF-I secretion and effects, but it has been able to do so in very large amounts. CJC 1295 Stimulates Growth Hormone Secretion, and will keep a steady increase of HGH and IGF-1 with no increase in prolactin, leading to fat loss, and increased protein synthesis thereby promoting growth.

Peptides are defined as a compound of two or more amino acids in which a carboxyl group of one is united with an amino group of another. With the elimination of a water molecule, a peptide bond is formed. To put it more simply, peptides are just small proteins. When the number of amino acids are less than 50, these are peptides. When higher than 50, these are proteins. The peptides are therefore small chains of amino acid which are present in all cells of the body. There are several kinds of peptides: oligopeptides, polymers, proteins, neuropeptides and peptide hormones. These are synthesized naturally by the body. Peptides will therefore be used primarily to make a more abundant amount of hormones in the body. The latter will then produce new hormones such as Testosterone or corticosteroids. It is these two hormones that are considered anabolic or indirect anti-inflammatory.

In 2010, the company heard word that bodybuilders were importing knock-off versions of the patent-protected peptide from China, and started licensing the manufacturing rights out to other companies in an attempt to compete, as this was determined to be a better course of action than attempting to sue the Chinese company for patent breach (7, 8). Desperate to recoup this investment, they invested a small additional amount into developing a technology that allowed the peptide to be absorbed through the skin, in collaboration with a company called Phosphagenics (4). The peptide was then licensed for use in BodyShaper, an anti-cellulite cream. Phosphagenics later dropped AOD9604 from BodyShaper, citing excessive expense and ineffectiveness (3).
Another side effect of the CJC-1295 is acromegaly, since it helps in increasing the levels of the growth hormone. Acromegaly is a condition where extra growth hormone is released even after the internal organs and the skeleton have finished growing. This causes thickening of the skin, deepening of voice, enlargement of jaws, and slurring of speech. Another effect of acromegaly is the swelling of the soft tissue in the internal organs. This could result in the weakening of the muscles of the internal organs, like the heart. This was tested during the phase 2 testing of CJC-1295.
Our customers are forever our highest need. We enthusiastically guarantee to make the greater part of your encounters with our banded together peptide organization is an ensured achievement. By doing this, we realize that we likewise increment our capability of procuring your trust and setting up a long standing and commonly advantageous relationship. We trust that you will allow us to give you the quality items that you require!
Our Doctor is available for consultations by appointment and can be made by contacting the support team. Our consultation, advice and support is 100% obligation free. All of our Peptides are prescribed by experienced Anti Ageing Doctors. They are then compounded at one of our Australian pharmacies and then shipped Australia wide to Brisbane, Sydney, Melbourne, Hobart, Adelaide, Darwin, Perth and all regional areas.
Yes, Ipamorelin can help you lose weight. But, if you are not exercising, and aren’t eating well, it can only do so much. There is no magical supplement which will undo laziness and a horrible diet – keep this in mind. When using it for fat loss, make sure you are exercising. Doing so will naturally increase weight loss results, as you are going to burn more calories, along with the caloric deficit you are already on, for greater results. Further, your diet matters. If you are eating 5000 calories of junk per day, no supplement will help you lose weight – no matter how potent it claims to be!
Because these peptides are so numerous and variable in structure, their effects are likewise varied and wide-ranging. One class of these peptides are known as growth hormone secretagogues, and cause the secretion of one’s own, natural hGH in the body. These peptides have been shown to be very useful in the treatment of age-related conditions, osteoporosis, obesity, and various chronic inflammatory diseases, and have several advantages over traditional hGH administration.
Due to the similarity of AOD9604 to the C-terminus component of hGH some parameters that are associated with hGH activity have been carefully monitored in the long-term studies: 1). Oral glucose tolerance tests (OGTT) were conducted to assess the effect of treatment on glucose handling. 2). Testing for any anti-AOD9604 antibodies in blood samples of participants was conducted to investigate if oral administration of AOD9604 resulted in the generation of neutralizing antibodies. 3). Serum levels of IGF-1 were measured to confirm the hypothesis that unlike hGH, AOD9604 does not act via IGF-1 or raise IGF-1 levels.
Peptide therapy encompasses numerous different drugs with varied effects, ranging from immune modulation and tissue repair to fat loss and muscle building. Our center has seen very positive results in patients with CFS, Hashimoto’s thyroiditis, Lyme disease, and fibromyalgia, among other conditions. Ask your physician or speak to a patient representative at (877) 508-1177 to find out if peptide therapy is right for you.
AOD9604 is a new synthetic peptide fragment that comprises a modified 15 amino acid region of GH with a tyrosine component to help stabilize the molecule. Similar to GH, AOD9604 aids weight reduction in rodent models of obesity and was originally developed for the treatment of obesity in humans [11]. Additionally, it does not stimulate the production of IGF-1 [10], has positive effects on the differentiation of adipose mesenchymal stem cells into bone, and was found to promote proteoglycan and collagen production in isolated bovine chondrocytes in an in vitro study by Metabolic Pharmaceuticals (patent applied [WO2013082667]). Its positive effects include promoting the repair of bone and cartilage in cases of OA.
TelewellnessMD® provides consulting and program recommendations for general health, age management, nutrition and other wellness healthcare needs through an online platform and network of wellness medical providers. Trim® Nutrition’s product line includes vitamins, supplements and protein shakes manufactured in CGMP facilities and proprietary nutrient injections compounded in a certified licensed pharmacy using the highest quality ingredients. Headquartered in Clearwater, Florida, Trim® Nutrition’s clinical staff of physicians, pharmacists, registered nurses, and research and development specialists are dedicated to the mission of Making Bodies Better™.
The truth is peptides are 100% “legal”. I can’t say this is the case for the professional athlete, as certain peptides are banned in sport – highlighted from the Essendon or Cronulla Sharks saga Nevertheless, for the everyday person like us, using these amino acid chains is no crime. In Australia, regulating guidelines such as the Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP No. 17), classify majority of peptides as a Schedule 4 substance, meaning that a prescription is necessary for supply and possession. With its own doctors on board, able to provide a script according to Australian prescribing guidelines, Peptides Online has been a key leader in this field.
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