Results: AOD 9604 had no effect on serum IGF-1 levels, which confirms the hypothesis that AOD 9604 does not act via IGF-1. Results of oral glucose tolerance test demonstrated that, in contrast with hGH, AOD 9604 has no negative effect on carbohydrate metabolism. There were no anti-AOD 9604 antibodies detected in any of the patients selected for antibody assay. In none of the studies did a withdrawal or serious adverse event occur related to intake of AOD 9604.
Perhaps. As Dr Larkins weighs in: "It's a different kind of chemical and physiological manipulation that goes way beyond what I'd call conventional hormone therapy. It's the next stage of technology that's come along to try and help people enjoy quality of life." A stage with an effect apparently significant enough to risk a professional athletic career for.

Finally, patients deficient in growth hormone who get IGF-1 injections have shown increased rates of fat loss and fat oxidation. One theory for this is that, as you’ve just learned, IGF-1 can suppress circulating insulin, which would allow more burning of fatty acids from fat cells. This makes sense, since we do know that fat cells contain IGF-1 receptors, and this means that IGF-1 can interact with fat cells.
We organise and run biennial international scientific conferences, satellites and support local state meetings. Our meetings are designed to be in the fashion of the relaxed Gordon conference – with about 200 delegates and with a friendly and a highly participatory atmosphere. We also have a strong commitment to our early career researchers and students.
Example 2 - Morning Injection ◦Wake up and inject your HGH Frag 176-191 (250mcg to 500mcg is a good dosage depending on your budget). ◦Wait as long as possible before having your first meal (the longer you wait the more fat you will burn). ◦When you do eat, try to make the meal high protein, low fat and low carbohydrate (example meat and salad/vegetables). ◦If possible, try to do some cardio in the hours after your injection to increase the fat burning effect.

Various experiments have been conducted to test the effectiveness of CJC 1295-DAC in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection. Mean half-life was shown to be 5.8-8.1 days, also after multiple doses mean IGF-1 levels remained above baseline for up to 28 days. No serious adverse reactions were reported in any group.

From the standpoint of protein synthesis and muscle repair, IGF-1 injections have also been shown to enhance the anticatabolic effects of insulin and to increase the protein synthesis normally induced by growth hormone. This is because, like insulin, IGF-1 encourages amino acid uptake into muscle cells, stimulates peripheral tissue uptake of glucose (which lowers blood glucose levels), and suppresses liver glucose production. That last fact is important and is actually why IGF-1 is even being considered as a diabetes-prevention drug. Insulin resistance can cause the liver to produce excess glucose, which then causes even more insulin insensitivity and can eventually result in type II diabetes, and IGF-1 can decrease the need for this type excessive insulin release.
This particular peptide offers therapeutic benefits similar to those of hGH. CJC 1295 is a growth hormone releasing hormone (GHRH) analogue. In other words, it is a molecule that serves the same purpose as does GHRH—the hormone that stimulates the anterior pituitary to release hGH. However, unlike GHRH, which has a half-life of only minutes after IV administration, CJC 1295 is able to remain active in the body for extended periods due to its ability to bind to a protein in the blood known as albumin and avoid degradation by various enzymes. CJC 1295 increases an important growth factor, IGF-1, in addition to hGH, leading to fat loss, lean muscle growth, and enhanced sleep.
CJC1295 is a 30 amino acid peptide, which primarily functions as a growth hormone releasing hormone analogue (mimicking the effect of GHRH). It was initially invented to treat deep fat deposits in people, because it is known that having an increase in our own growth hormone levels will target this. It stimulates production of our own growth hormone from the pituitary gland.

The known side effects of IGF-1 injections include jaw pain, facial and hand swelling and heart-rhythm disturbances, especially if doses of more than 100 micrograms (mcg) are injected. Exceeding 100mcg of IGF-1 can actually cause your heart to stop beating and blood pressure to drop dramatically. This is caused by an IGF-1-induced drop in blood phosphate levels, and in the bodybuilding community is often prevented by administering phosphate with the IGF-1.
Not every peptide will suite every individual and it may take some experimenting to get the right peptide and dose. Our recent article explains more about who peptides will work for. So what is the best peptide for fat loss and is there any one type that will almost guarantee some success? The answer is NO! Everyone is different and to repeat what was said above, experimenting is vital for success.
We found that osteoarthritic rabbits administered intra-articular AOD9604 injections had better outcomes with lesser morphological and histolopathological damage than was observed in the control group. AOD9604 is a disulphide-constrained peptide that comprises 15 amino acids from the C-terminal sequence of human GH and an additional N-terminal tyrosine residue: YLRIVQCRSVEGSCGF [15]. The exact mechanism underlying the action of GH in OA is unknown. Previous studies have shown that GH can act directly on the growth plate by stimulating local production of IGF-1 and by increasing cartilage metabolism [9,16] and chondrocyte proliferation [17]. Although AOD9604 is not a high-affinity agonist of the GH receptor and does not stimulate the proliferation of cells transfected with the GH receptor, it retains some functions of GH [11]. Initially, AOD9604 was investigated for the treatment of obesity in humans. In rodent models of obesity, AOD9604 showed a similar effect of weight loss as that observed with GH [11]. However, AOD9604 does not induce diabetes and does not stimulate the production of IGF-1 [10].
Although growth hormone and growth hormone releasing hormones are classified as prescription drugs, there is a safe and legal way to increase your levels of hGH production. There are a range of growth hormone supplements designed to boost hGH production within normal limits. For more information, please refer to our “Natural Growth Hormone Supplements Guide”.
Peptides are defined as a compound of two or more amino acids in which a carboxyl group of one is united with an amino group of another. With the elimination of a water molecule, a peptide bond is formed. To put it more simply, peptides are just small proteins. When the number of amino acids are less than 50, these are peptides. When higher than 50, these are proteins. The peptides are therefore small chains of amino acid which are present in all cells of the body. There are several kinds of peptides: oligopeptides, polymers, proteins, neuropeptides and peptide hormones. These are synthesized naturally by the body. Peptides will therefore be used primarily to make a more abundant amount of hormones in the body. The latter will then produce new hormones such as Testosterone or corticosteroids. It is these two hormones that are considered anabolic or indirect anti-inflammatory.

Tβ4 has been used at our clinic with a great deal of success in patients suffering from Lyme disease or other infectious and/or inflammatory conditions. Tβ4 is very well tolerated and has not been found to cause any significant side effects. It can be taken on its own or in conjunction with an existing therapy, making it a versatile and valuable drug.


OxySelect Pink is an advanced thermogenic and is the only diet pill specifically formulated to enhance the curves of a woman’s body. While other products contain stimulants and huge quantities of dubious fillers and preservatives, OxySelect Pink uses clinically-tested, all-natural extracts designed to help you lose weight. OxySelect Pink is one of the best choices for women looking to get leaner.
No growth hormone, or any supplement for that matter, is never going to equate to the same exact results for every user. So, what you experience, is not the same as the next user, and vice-versa. Further, the increase in results and how quickly you will see these results are going to differ for each user. So, make sure you understand this prior to start your dosage, to ensure you are not disappointed if you do not see each one of these benefits, on the very first day that you begin using the Ipamorelin. Also consider the fact that if you use it after food, or with a meal, results will improve. So, proper timing and proper diet and exercise regimen can greatly enhance the results you are going to realize when you are using Ipamorelin as well.
The increase in GH secretion due to IPAMORELIN (and other GHRP) leads to an increase in IGF-1 (thought to be the anabolic mechanism of GH).  As we get older GH and subsequently IGF-1 decrease substantially.  This decline is thought to be one of the major causes of the ageing process.  By increasing these levels again there is increased collagen synthesis, promotion of lean muscle mass, bone strength, improved healing capability, improved sleep cycle, increased energy, repair and regeneration of internal organs, strengthening of joints/cartilage/connective tissue, and anti ageing effects on the skin. 
Now that I’ve told you about the benefits of collagen supplementation and how it can help in weight management, you may want to know which collagen supplement to use. There are a lot of collagen supplements out there, and I’ve tried most of them. I highly recommend you do your research to make sure you purchase one that contains no additional additives, flavors, or sweeteners. Also make sure the collagen has no hormones in it: look for collagen from grass fed and pasture-raised bovine or wild-caught fish. For those reasons, I recommend and Further Food Collagen Peptides - a brand I use and recommend to others.

During the hydrolysis process, whole proteins are broken down into smaller peptide fragments. These can sometimes be as short as two or three amino acids in length (known as di- and tri-peptides). The benefits of hydrolysed protein have been outlined in detail elsewhere. In short, hydrolysed proteins are much faster absorbed than other forms of protein. It has been shown that hydrolysed whey protein can increase the time of recovery compared to whey protein isolate (WPI) (Buckley et al, 2010).
Another benefit of CJC 1295 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS decreases significantly in older adults and also with people who tend to exercise later in the evening. Clinical studies have shown that a once-daily administration of CJC 1295 normalizes the GHRH response and can induce significantly deeper sleep.
The knee joints were dissected after euthanasia. The medial and lateral condyles of the femur and tibia were examined for gross morphological changes. The degree of cartilage degeneration on the lateral part of the femoral condyle was assessed using the scoring system devised by Yoshimi et al. [12]. This area was assessed because the intra-articular collagenase injections had caused most damage at this area [13]. Normal cartilage was scored as 0, softened cartilage as 1, fibrillated cartilage as 2, eroded cartilage as 3, ulcerated cartilage as 4, and loss of cartilage as 5.

Tβ4 has been used at our clinic with a great deal of success in patients suffering from Lyme disease or other infectious and/or inflammatory conditions. Tβ4 is very well tolerated and has not been found to cause any significant side effects. It can be taken on its own or in conjunction with an existing therapy, making it a versatile and valuable drug.
The most common goal of people in the health and fitness world is to lose weight. Not only do hundreds of millions of people go on diets to try and lose weight every year, but they want to lose weight as fast as possible. It’s no wonder the weight loss industry is a $20 billion industry, with the sales of books, diet drugs, and weight-loss surgeries fueling revenue as people try and lose unwanted weight once and for all.
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used in the management of mild to moderate pain and inflammation in conditions such as dysmenorrhoea, headache including migraine, post-operative pain, dental pain, musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis including juvenile idiopathic arthritis, peri-articular disorders such as bursitis and tenosynovitis, and soft tissue disorders such as sprains and strains. It is also used to reduce fever.

Several epidemiologic studies have reported lower circulating natriuretic peptide concentrations in obese individuals.12, 14 However, these studies have been observational and confined to a single time point of measurement of natriuretic peptides. To our knowledge, only one previous study has examined the association of obesity with salt‐induced natriuretic peptide concentrations. Licata and colleagues found reduced, salt‐loaded plasma ANP concentrations in 9 obese individuals compared with 10 lean controls.21 They did not examine the influence of weight loss on the natriuretic peptide system. Thus, the present study is the first to provide serial, physiologic data from the same individuals over time.


If you are interested in order a product you will need to fill out our quick 2-minute Medical Questionnaire. As we provide Schedule 4 medication we require your medical details so our Prescribing Doctor can provide you with the safest and most effective solution for your health and fitness goals. If you have any further questions surrounding our Order Process please feel free to call out Customer Support team to discuss any concerns.
The ACMS recommended listing Growth Hormone Releasing Hormones (GHRHs), Growth Hormone Secretagogues (GHSs), Growth Hormone Releasing Peptides (GHRPs) as well as new individual substance entries for CJC-1295, ipamorelin, pralmorelin (Growth Hormone Releasing Peptide-2), Growth Hormone Releasing Peptide-6, hexarelin and AOD-9604 in Appendix D, Item 5.
IGF-1 is so named because of its close resemblance to insulin. Because IGF-1 is so similar to insulin, it interacts with insulin receptors on the surface of your cells, produces some of the same effects as insulin and even magnifies the effect of insulin. For example, one primary effect of both excess insulin and excess IGF-1 is hypoglycemia (low blood glucose). When you workout for a long time (longer than about one hour) your liver increases its release of IGF-binding protein (IGFBP-3) to prevent the onset of hypoglycemia that would otherwise happen as a result of the increased release of IGF-1 that occurs during training.

Ironically, it only appears that the version of IGF-1 produced in your own muscle has any true anabolic effects. But nonetheless, many folks who’ve used IGF-1 claim to have experienced significant anabolic effects of injections. However, the only evidence for such anabolic effects have been shown in people who are already clinically deficient in IGF-1.
As we offer Schedule 4 medication we require your medical details so our Prescribing Doctor can provide you with the safest and most effective solution for your health and fitness goals. If you are interested in order a product you will need to fill out our quick 2-minute Medical Questionnaire. If you have any further questions surrounding our Order Process please feel free to call out Customer Support team to discuss any concerns.
Peptides are not to be confused with synthetic human growth hormone drugs, which are injected into the bloodstream to provide rapid results. HGH is said to be Hollywood's secret weapon, with top stars, filmmakers and studio execs hooked on the youthful effects, but synthetic hGH is tightly regulated in Australia and verboten unless there's a proven growth hormone deficiency (most cases are in children).
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