The process to get a cream doesn't happen overnight. Explains Smeath: "A patient will complete a comprehensive medical questionnaire, which is sent to one of our prescribing doctors. [They] review all medical notes, make contact with the patient and once approved, send a prescription to one of two TGA-approved compounding pharmacies in Australia who ship [the peptides] directly."
The effects of hGH and AOD9604 on fat metabolism may be mediated by an alteration in the expression of a lipolytic/antilipogenic gene. Theβ 3-AR is a major lipolytic receptor identified in rodent fat cells (18) that mediates its effects through G protein coupling to adenylate cyclase, generation of cAMP, and stimulation of PKA (19). This enzyme then phosphorylates proteins in the lipolytic cascade, including hormone-sensitive lipase (20). In BAT, the β3-AR stimulates uncoupling of the electron transport chain, enhancing the ability of mitochondria to generate heat in preference to ATP through the dissipation of the electron gradient (21). Mice that lack this receptor have lower rates of resting energy expenditure (0.0041 vs. 0.0047 kcal/min, P < 0.02) and lower rates of fat oxidation (0.00019 vs. 0.00030 g/min, P < 0.02) than control mice (data not shown).
Improved glucose metabolism after RYGB and sleeve gastrectomy involves several mechanisms: early increased hepatic insulin sensitivity, resulting from reduced liver fat content in response to the postoperative caloric restriction, improved beta-cell function mediated by exaggerated postprandial GLP-1 secretion; as demonstrated by relapse of impaired glucose tolerance in studies blocking the GLP-1 receptor by exendin 9–39, and later after major weight loss increased peripheral insulin sensitivity. Gut hormone secretion changes towards a more anorectic profile and is likely important for less caloric intake and weight loss.
A synthetic analogue (AOD9604) of the lipolytic domain of human growth hormone (hGH) has been studied for its metabolic actions in obese Zucker rats. Daily treatment with an oral dose of AOD9604 of 500 microg/kg body weight for 19 days reduced over 50% (15.8 +/- 0.6 vs. 35.6 +/- 0.8 g) body weight gain of the animals in comparison with the control. The adipose tissues of the AOD9604--treated animals were found to have an increase in lipolytic activity. In contrast to chronic treatment with intact hGH, chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity of the animals, as demonstrated with euglycemic clamp techniques. The results in the present study suggest that the analogue of the hGH lipolytic domain may have the potential to be developed into an orally usable and safe therapeutic agent for obesity.

Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural Growth Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormone. Like Growth Hormone, AOD 9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food materials into body fat) both in laboratory testing and in animals and humans. Recent findings have shown, in addition to its fat loss properties, AOD 9604 processes many other regenerative properties associated with growth hormone. Currently trials are underway to show the application of AOD 9604 in osteoarthritis, hypercholesterolemia, bone and cartilage repair. AOD 9604 has an excellent safety profile, recently obtaining Human GRAS status in the USA.

Statistical analysis was performed using SPSS version 14.0 (SPSS, Chicago, Ill). The differences of gross morphological and histolopathological findings and lameness period among four groups were assessed using the Kruskal–Wallis test. The Mann–Whitney U test was used to compare the gross morphological and histolopathological findings and lameness period between two groups, and p-values <0.05 were considered statistically significant.

Ipamorelin, like other growth hormone peptides, is used to increase production of your own growth hormone levels. Growth hormone levels are at their peak in our twenties, and then gradually decrease with age. There are a few different peptides including Sermorelin, GHRP2, GHRP6, and Ipamorelin. These peptides are listed in order of how recently they have been developed, with Ipamorelin being the newest and most commonly recommended.

The acute effect of AOD9604 and BRL37344 (aβ 3-AR agonist) on energy expenditure and substrate oxidation rates in WT and KO mice was also assessed. KO animals had lower energy expenditure, lower fat oxidation, and increased glucose oxidation, compared with the WT controls (data not shown). Injection of WT mice with a single dose of BRL37344 or AOD9604 increased energy expenditure and fat oxidation and decreased glucose oxidation. In the KO animals, BRL37344 failed to elicit any response in these metabolic parameters, clearly demonstrating that its effects are mediated exclusively through the β3-AR. AOD9604 did elicit a response in the KO mice, increasing fat oxidation and energy expenditure, although the response was not as great as in WT mice, suggesting that β3-ARs are not responsible for the acute biological response of AOD9604 on lipid metabolism. This is consistent with our previous findings in which AOD9604 was shown not to bind to the β3-AR (11). The size and duration of the metabolic responses to AOD9604 in the β3-AR KO animals was different from that observed in the control wild-type mice. The response was more rapid, shorter in duration, and greater in peak response. This may be because the KO animals are more acutely sensitive to lipolytic agents, a compensation for the ablation of the major lipolytic receptor.

Cartilage loss in OA is caused by proteoglycan depletion and chondrocyte death that in turn are caused by imbalances between catabolic and anabolic activities within the joint [5]. Growth hormone (GH) has been shown to correct this imbalance [6]. Although the exact mechanism underlying the effects of intra-articular GH injection is not known, GH in the synovial fluid probably enhances proliferation, matrix synthesis, and differentiation of bone and cartilage cells in vitro [7]. Studies have found that GH accelerates healing in animal models of OA [8,9]. However, intra-articular GH injections in humans are known to have detrimental pro-tumor and pro-diabetic effects. These negative effects are caused by the secondarily produced insulin-like growth factor-1 (IGF-1) [10].
As it is not yet approved for use in this country (or any other), it should always have been considered banned under the S0 category, which states that any pharmacological substance that is not addressed by any of the subsequent sections of the Prohibited List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited.

These findings suggest that the acute effects of AOD9604 are quite different from the chronic effects. Enhancedβ 3-AR expression appears to play a major role in the chronic effectiveness of the compound in terms of fat metabolism and weight loss. The acute effects observed in this study confirm that the β3-AR is not the sole mediator of this action. The increase in β3-AR expression in response to hGH and AOD9604 would permit enhanced lipolytic sensitivity. Identification of the components of the intracellular pathway(s) and effector(s) activated by AOD9604 are currently being investigated. The results presented in this paper suggest that the effectiveness of AOD9604 and hGH may partly rely on their ability to increase levels of β3-AR RNA expression in models of obesity in which the numbers of the lipolytic receptor are low. These unique properties may give AOD9604 an advantage over other lipolytic agonists such as adrenergic agents and hGH, which exhibit undesirable side effects when administered chronically (22).
"Paracetamol is used worldwide for its analgesic and antipyretic actions and has been available in Australia since 1956. Caffeine is a stimulant and acts as an analgesic adjuvant, whereby it augments the analgesic effects of pain relievers such as paracetamol. The combination of paracetamol/caffeine (2x500mg/65mg) is indicated for temporary relief of pain and discomfort associated with headaches, tension headaches, osteoarthritis, arthritis, cold and flu symptoms, toothache, dental procedures, muscular aches, sore through and period pain. It also reduces fever.
When you increase the dosage gradually it is also going to ensure you do not experience all (or any) of the noted side effects which are possible with the use of Ipamorelin. And, if you are taking other peptides, supplements, or growth hormones, it is the best way to ensure they are going to acclimate well and work together well, in order for you to realize the greatest results possible when trying to increase muscle mass, and lean muscle tissue, without putting on body fat in the process.
The T α 1 peptide can be administered via subcutaneous injection or as a transdermal cream. T α 1 has been found to be very safe, and there have not been any documented side effects associated with its administration. It is approved in more than 37 countries for the treatment of hepatitis B, hepatitis C, and as an adjunct to chemotherapy and various vaccines.
This peptide is a modified fragment of hGH which contains the portion of the molecule that is believed to be responsible for hGH’s anti-obesity effects. The peptide has been shown to increase fat burning without the increase in blood sugar and growth rate that has been seen with hGH itself. AOD 9604 has been deemed safe for chronic use by the FDA, receiving Human GRAS status in 2014. In addition to its utility as an anti-obesity peptide, AOD 9604 has been shown to have very favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157.
For example, insufficient protein or calories can cause IGF-1 to plummet, while ample calories can cause IGF-1 to increase. For example, one study of women who fed with excess calories over and above their normal metabolic rate noted a 19% increase in IGF-1 after two weeks of overfeeding, with 46% of the weight gain from  lean mass and 54% from bodyfat. Fasting insulin doubled in these women, and testosterone levels also significantly increased.
In the first dose-escalating study (METAOD001) 15 healthy male subjects received 3 single dosages of AOD9604 and placebo as single dosages each separated by a 7-day washout period (range 25 to 400 µg/kg bodyweight; single IV infusion doses over 20 minutes). One subject terminated the study due to personal reasons, 14 subjects completed the study. In total twenty-nine AEs were reported by twelve subjects during the study. No SAEs occurred during this study. The most common AEs reported during the study were headache (6 times). The remainder were related to fatigue (4), hypoglycemia unspecified (3), dizziness (3), nasopharyngitis (2), cough (2) and lethargy, tonsillitis, abdominal pain unspecified, application site reaction unspecified, sore throat unspecified, injection site bruising, rhinitis seasonal, anorexia, injection site pain, all with an incidence of 1. None of the AEs were of severe intensity. The majority of AEs were mild in intensity with possible relationship to study treatment, equally distributed between the various concentrations of AOD9604 and placebo treatment. The adverse event profile was similar following administration of all treatments.
WT (n = 9) and β3-KO (n = 9) mice were used in this study. Animals were fasted 2 h before being individually placed in an indirect calorimeter. Calorimetry was performed as in previous studies (8). After baseline readings were taken, mice were injected with one of the following compounds: saline (control; n = 3); AOD9604 (2 mg/kg body weight; n = 3); or BRL37344 (250 μg/kg body weight; n = 3). Rates of energy expenditure, fat oxidation, and glucose oxidation were measured for an additional 30 min. The concentrations of AOD9604 and BRL37344 were determined as lowest concentration needed to give a maximal response in these mice (data not shown). Rates of energy expenditure and fat and glucose oxidation were plotted as a change from the average baseline values.
A total number of 207 AEs were reported by 36/36 subjects. All but one was of mild to moderate intensity (placebo-treated subject, soft tissue injury to left shoulder, unrelated to study treatment). No SAE occurred during the 7-day treatment and the 7-day follow-up time. The rate as well as the AE profile was comparable in the 9 mg, 27 mg AOD9604 and the placebo group. There was no observable trend between treatment groups with respect to the incidence of certain AEs, however subjects who received 54 mg AOD9604 experienced a greater number of headaches, diarrhea and flatulence.
Tβ4 has been used at our clinic with a great deal of success in patients suffering from Lyme disease or other infectious and/or inflammatory conditions. Tβ4 is very well tolerated and has not been found to cause any significant side effects. It can be taken on its own or in conjunction with an existing therapy, making it a versatile and valuable drug.

Three of the submissions did not support the proposal highlighting the impact the change in scheduling would have on product currently on the market, industry, pharmacists and consumers. Two submissions noted that there has not been a history of concern with this combination of substances. One submission, referring to the NEJM article, believed that a lack of information about the study means that it cannot be relied upon as there is not a meaningful assessment of the results.

The prescription form of IGF-1 most often injected is “mecasermin”, which goes by the trade name Increlex. Manufactured using recombinant DNA technology, mecasermin is clinically used to treat IGF-1 deficiency and stunted growth. It is also prescribed to patients who have developed antibody resistance to normal growth hormone therapy. Increlex is actually identical to natural IGF-1, meaning that it has the identical 70 amino acid sequence of IGF-1 that the body produces. In other words, it’s not some kind of growth hormone “precursor”. It’s just straight up IGF-1.

Managing your weight is a hard task no matter your age. But as we age there are extenuating factors that make weight loss even harder. Lifestyle factors, having a desk job, less physical activity, hormone changes e.g. insulin sensitivity or sleep deficiency. While exercise and healthy eating are vital for weight loss, sometimes that’s easier said than done! That’s where we come in. You set the Resolution and we find you the Solution!

I was using MT II while using the 1st vial and lost 14 lbs in 10 days. Had to fly to Pittsburgh for a couple days and started 2nd vial with no MT II and dropped 8 more. I weighed yesterday upon completion of the 2nd vial with shoes and clothes on. Was very pleased with the results. I did a cycle of T3 prior to the frag and didnt do near as well and was fighting muscle loss, felt like crap ect.. Will be purchasing more, I use Southern Research on the peptides.
However, after the administration, Mod GRF 1-29 starts breaking down soon. This happens because peptides have a strong affinity for bonding with amino acids. The administered peptide has to travel a long distance between the point of administration and the pituitary gland. On the way, the enzymes act on it making it break down and bond with the amino acids. The peptides that are secreted by the body on its own do not have to face this problem because they do not have to travel this long.

Another benefit of CJC 1295 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS decreases significantly in older adults and also with people who tend to exercise later in the evening. Clinical studies have shown that a once-daily administration of CJC 1295 normalizes the GHRH response and can induce significantly deeper sleep.

EPO: Erythropoietin (EPO) is a naturally occurring hormone found in the blood, but media usually refer to the artificial peptide (recombinant EPO). EPO stimulates production of red blood cells to improve oxygen transfer and boost endurance or recovery from anaerobic exercise. EPO is also believed to increase the risk of adverse health effects, but this has mainly been based on athletes’ anecdotal evidence and clinical studies in non-sports patients with other medical conditions. While using recombinant EPO is prohibited both in and out of competition under WADA’s Prohibited List, “natural” boosting of EPO through high altitude training is allowed.
Specifically, T α 1 has been shown to enhance the function of certain immune cells called T and dendritic cells. This is very important to anyone with a depressed immune system or suffering from an infection, as these white blood cells play pivotal roles in the body’s defense process. T cells, for example, come in two forms: killer and helper T cells. Killer T cells are responsible for hunting down and destroying our body’s own cells that are cancerous or infected with bacteria or viruses. Helper cells work with the other cells of the immune system to orchestrate and carry out appropriate immune responses.
If there's one thing that science has definitively said about AOD9604, it is that it is safe and has no side effects. Calzada, after trying the peptide out as an anti-obesity and anti-arthritic, has succeeded in having the peptide declared "Generally regarded as safe" by the FDA, which makes it legal to use as a food additive in America. Calzada, seemingly under no pretense that their product has pharmaceutical properties, is now trying to break into the US over the counter supplement and "Nutraceutical" market with AOD9604 (2,4). Interestingly, the compound has only been approved for use in levels of up to 1mg per day (2), whereas the doses used in trials generally hovered around 500ug/kg (5,6), which means a 100kg person was receiving 50mg of the peptide daily. There is no science behind the peptide, or the dosage, and Calzada themselves have previously said AOD9604 is not effective orally (2).

Five public submissions were received. Many of the submissions referred to the article published in the New England Journal of Medicine (NEJM) when giving their reasons for either supporting or rejecting the proposal. Some submissions also noted that a similar proposal is to be considered by an upcoming meeting of the Medicines Classification Committee (MCC) in New Zealand.
For CJC-1295 DAC there are no particular diet restrictions that need to be followed due to its long half-life. For GHRP products the following should be observed as insulin and fatty acids can blunt the release of GH in the body and therefore make your injections less effective: •Avoid eating/drinking anything high in fat for 3 hours before your injection and anything high in carbohydrates for 1-2 hours (always do your injection on an empty stomach). •Wait at least 20 minutes after your injection before eating/drinking anything with calories.
Obesity affects as many as one in five adults in developed countries. Metabolic estimates that the potential worldwide market for effective obesity drugs is as much as $20 billion, far more than the current market of $1.5 billion. This is partly due to the potential need for chronically obese people to take obesity drugs such as AOD9604 and also because patients are put off using currently available drugs because of their marginal efficacy or side-effects.
To put this into simple terms, collagen protein promotes fullness and keeps our body feeling satisfied after a meal. If we feel more full for a longer time after eating, we are less likely to overeat at the next meal. This goes hand in hand with fighting off pesky cravings. We know how difficult it can be to fight cravings, such as those for salty, oily or fatty foods. And not to mention sugary foods, which our brain can actually get addicted to. Including collagen into your daily diet can help in the battle against cravings and weight loss by keeping you full and satisfied.

recently studies found that in the process of destroying the fat cells, it shook stem cells which are inside the fat cells giving rise to new found REGENERATIVE POWERS of AOD. It works well at regenerating ligaments after significant damage and muscle repair, by increasing cartilage and collagen production in your joints. It has also been seen to improve bone density which can have positive effects on osteoporosis.
TelewellnessMD® provides consulting and program recommendations for general health, age management, nutrition and other wellness healthcare needs through an online platform and network of wellness medical providers. Trim® Nutrition’s product line includes vitamins, supplements and protein shakes manufactured in CGMP facilities and proprietary nutrient injections compounded in a certified licensed pharmacy using the highest quality ingredients. Headquartered in Clearwater, Florida, Trim® Nutrition’s clinical staff of physicians, pharmacists, registered nurses, and research and development specialists are dedicated to the mission of Making Bodies Better™.
There’s never been a better formula to help you reach your weight loss goals with patented, clinically-proven, and all-natural ingredients. While being one of the most powerful formulas on the market, it’s the safest as well. The best part is each and every bottle is backed by a 90-day, 100% Money Back Guarantee, making Apidren completely RISK FREE! With these clinically proven ingredients and industry-leading money back guarantee, there’s no other diet supplement we would recommend! Read More
In this study, AOD9604 was given in a dose of 0.25 mg that is comparable to the dose used in a previous report [8] on GH in promoting recovery to normal walking and in joint repair in the rabbit collagenase model of osteoarthritis. AOD9604 is a fragment of GH; therefore the dose of AOD9604 used was the molar equivalent of the active GH dose that the previous study [8] used. Human GH was given as 3 mg in 0.6 ml intra-articular injection volume. On a molar basis, 3 mg of GH equates to 0.25 mg of AOD9604. In addition, published data [10] suggest that the volume of synovial fluid in an arthritic rabbit is approximately 0.7 ml. Combined with the injection volume, this gives a total volume of 1.3 ml and therefore an initial concentration of AOD9604 of 0.19 mg/ml. In a previous study [11] of GH in the beagle after intra-articular injection, researchers injected 1.5 mg of GH in aqueous solution in 0.15 ml volume. The aqueous formulation gave an initial concentration of approximately 200–300 ug/mL in the synovial fluid. On a molar equivalent basis this equates to 0.11 mg/mL of AOD9604, which is close to the value used in this study.
AOD aka Advanced Obesity Drug., Fat Loss Peptide AOD 9604 consists of the get along 15 amino acids of the human wealth hormone molecule. The considerable thing close but no cigar AOD 9604 is it has no doom on accomplishment or insulin resistance. With an fine safety sketch of minimal side chattels personal, AOD 9604 has been proven more effective than consequently occuring Growth Hormone at fresh the collapse of fat. Studies have proven its efficiency to reduce biggest slice of the cake full, by way of explanation in the abdominal area.
Ironically, it only appears that the version of IGF-1 produced in your own muscle has any true anabolic effects. But nonetheless, many folks who’ve used IGF-1 claim to have experienced significant anabolic effects of injections. However, the only evidence for such anabolic effects have been shown in people who are already clinically deficient in IGF-1.
Background: The human growth hormone (hGH) has properties making it a potential candidate to treat obesity, however safety issues limit its long-term use. AOD9604 is a peptide fragment of the C-terminus of hGH (Tyr-hGH177-191), which harbors the fat reducing activity of hGH, without its negative effects. In this paper the safety data of AOD9604 obtained in clinical trials are summarized.
IGF-1 Peptides: include IGF-1 LR3 and IGF-1e (also known as MGF or Mechano Growth Factor). IGF-1 is responsible for many of the positive effects of GH on fat loss and muscle building therefore they offer a good addition, especially if your goal is to build muscle, as they are both responsible for creating new muscle cells which can hypertrophy (get bigger) through weight training.
Three of the submissions did not support the proposal highlighting the impact the change in scheduling would have on product currently on the market, industry, pharmacists and consumers. Two submissions noted that there has not been a history of concern with this combination of substances. One submission, referring to the NEJM article, believed that a lack of information about the study means that it cannot be relied upon as there is not a meaningful assessment of the results.
As both CJC1295 and Ipamorelin bind to the pituitary gland and prompt the release of GH, when used together, the production of growth hormone is over 10 times more than when used individually. As it stimulates the body’s natural growth hormone production it also causes the release of IGF-1. The advantages of the CJC peptide is that it helps increases bone density and collagen, as well as boosting the immune system. It will also produce new muscle cells which will be leaner and increases weight loss. The CJC 1295 results are part of years of scientific studies. It primarily increases the production of proteins, which leads to stable bodily functions related to the glands in the body or the endocrine system.
I stopped the colostrum and my ” symptoms ” subsided, seems I have a moderately enlarged prostate which doesn’t run in my family on either side, my question is could the colostrum possibly cause the prostate to enlarge due to the igf-1 at a certain age,? due to a possible decline in testosterone, or could the benefits of colostrum outweigh the prostate issue?
After about a week of taking the collagen, I noticed my nails were thicker and stronger and were growing faster. Usually, my nails break and tear off after they grow, but after drinking my collagen, they were growing nicely and faster than normal. In fact, when I got a gel manicure, which is supposed to last up to two weeks, my nails grew out after about eight or nine days, leaving the bottoms of my nail beds exposed. Although it was annoying having to get my nails redone, it wasn’t a bad problem to have!
In 2010, the company heard word that bodybuilders were importing knock-off versions of the patent-protected peptide from China, and started licensing the manufacturing rights out to other companies in an attempt to compete, as this was determined to be a better course of action than attempting to sue the Chinese company for patent breach (7, 8). Desperate to recoup this investment, they invested a small additional amount into developing a technology that allowed the peptide to be absorbed through the skin, in collaboration with a company called Phosphagenics (4). The peptide was then licensed for use in BodyShaper, an anti-cellulite cream. Phosphagenics later dropped AOD9604 from BodyShaper, citing excessive expense and ineffectiveness (3).
This particular peptide offers therapeutic benefits similar to those of hGH. CJC 1295 is a growth hormone releasing hormone (GHRH) analogue. In other words, it is a molecule that serves the same purpose as does GHRH—the hormone that stimulates the anterior pituitary to release hGH. However, unlike GHRH, which has a half-life of only minutes after IV administration, CJC 1295 is able to remain active in the body for extended periods due to its ability to bind to a protein in the blood known as albumin and avoid degradation by various enzymes. CJC 1295 increases an important growth factor, IGF-1, in addition to hGH, leading to fat loss, lean muscle growth, and enhanced sleep.

Strengths of our study include the serial physiologic assessments before and after bariatric surgery. The gastric bypass procedure ensured a large degree of weight loss (≈27% mean change in BMI), while the administration of normal saline provided an acute stimulus for eliciting acute natriuretic peptide responses. Thus, we were able to compare the relative effects of weight loss and saline infusion, with each individual serving as his or her own control. This study design minimizes confounding from sources of natriuretic peptide variation that might correlate with BMI. We performed the post‐surgical assessment 6 months after surgery to ensure that acute hemodynamic changes from surgery had resolved and patients had attained most of their expected weight loss. Mitral annular early diastolic (e′) velocity at the lateral annulus has been accepted as an index of diastolic function24, 25 and we had significant improvement in e′ suggesting improvement in myocardial relaxation. Our echocardiographic findings are in accordance with the recently published meta‐analysis demonstrating benefits of bariatric surgery on diastolic function.26
To buy our premium peptides online you will need to complete a simple online medical questionnaire. This is a legal requirement due to the regulation of Peptides in Australia. We cannot legally advertise specific Peptides to the general public without first ascertaining you are over 18 years of age and have submitted the required medical questionnaire. Learn more about Muscle Peptides Australia services.