Colostrum: The very early form of milk secreted late in pregnancy and in the first few days after birth, colostrum contains a complex mixture of nutrients, antibodies (to build immunity) and growth factors (to stimulate gut development) which are important to a newborn’s health and development, though its effects in adults are less clear. There’s little evidence that colostrum consumption (typically cow colostrum) improves the immune status of athletes. While not directly banned, colostrum could stimulate Insulin-Like Growth Factor-1 (IGF-1) secretion. IGF-1 is banned, but stimulation of its secretion by nutritional supplements is a grey area.
All studies were performed as double-blind placebo-controlled trials with specific design adaption depending on the question that was to be answered. All, but the first, were performed on obese, but otherwise healthy, adults. In the first 4 studies, only male subjects were included (supplementary data). Approximately 900 adult subjects participated in these 6 clinical trials.
Wow you are really thick arnt you... ok lets call it a drug if it floats your boat... if you bothered to actually understand how it works you would probably have an enlightning moment as to why itssuch a debatable comment... its a peptide a very complex string that stimulates the p gland... the p gland that creates GH stimulation from our own body... it has nothing to do with being a varient of gh like YOUR FACTS state... this is why its under SO and arguable as a PED... do you even know what an amino acid chain is...? Obviously not...

I’m 50 and have been using CJC-1295+Ipamorelin Combo for almost 1 year now. Yes with 2 rest periods. Very very happy with the results. Skin is smoother / softer to touch reduced bags under my eyes, my wife loves the new feel. I train 5 days a week and the increase in muscle volume and tone is very noticeable. I will say however it is a slow steady natural looking increase. Recovery is great and I think it is helping with injury repair, as i have a problem Knee that is feeling alot better ever since I’ve been on this product. As you can see the cost is high but if there were no outstanding results my wife would say I was a Di#*head, but she is encouraging me to continue. Train hard, eat well and look better. Use CJC-1295+Ipamorelin Combo. I do
Obesity affects as many as one in five adults in developed countries. Metabolic estimates that the potential worldwide market for effective obesity drugs is as much as $20 billion, far more than the current market of $1.5 billion. This is partly due to the potential need for chronically obese people to take obesity drugs such as AOD9604 and also because patients are put off using currently available drugs because of their marginal efficacy or side-effects.

Eligible study subjects were admitted after overnight fasting for an outpatient visit at the MGH CRC. Upon admission, two intravenous catheters were placed for phlebotomy and 10 mL/m2 of body‐surface area (BSA)/minute normal saline (0.9 mEq/mL) was infused over 2 hours. Blood pressure, heart rate, and oxygen saturation were measured every 20 minutes during the saline infusion. BSA was calculated according to the DuBois algorithm (BSA (in m2)=0.20247×height (m)0.725×weight (kg)0.425). Venous blood was sampled beginning immediately prior to the start of the infusion and at 40, 80, 120, and 180 minutes after the start of the infusion.

However, both the original GRF (1-29) and the Mod GRF 1-29 required frequent dosages. So a new compound called CJC-1295 was created which was far more stable. This compound was made by adding Lysine – which is a non-peptide, and is also called Drug Affinity Complex or DAC. Since the original Mod GRF 1-29 does not contain DAC, it is named as CJC-1295 without DAC. However, the actual CJC-1295 is not only difficult, but also very expensive to produce. This is why it is not produced or used extensively. The Mod GRF 1-29 is far easier and cheaper to produce.


As in the previous study there were no clinically relevant changes observed in safety laboratory parameters 24 hours following administration of AOD9604 or placebo. Similarly, there were no clinically relevant changes in vital signs (blood pressure, radial pulse rate and temperature) or ECGs recorded at any of the scheduled time points up to 24 hours post dose. There were no significant changes in glucose or IGF-1 levels following AOD9604 treatment compared with placebo.
In vitro studies by Metabolic Collaborators showed that AOD9604 enhances the differentiation of adipose mesenchymal stem cells into bone, promotes proteoglycan and collagen production in isolated bovine chondrocytes, and promotes differentiation of myoblasts into C2C12 cells. These effects induced by AOD9604 are similar to those required for the repair of bone, cartilage, and muscle, all of which are affected in OA. To the best of our knowledge, no study has compared the effects of GH and HA intra-articular injections on OA. A previous study showed the effects of intra-articular GH injection on articulophyseal cartilage regeneration in the knees of rabbits [9]. Our study showed that the groups that received AOD9604 or HA injection had better outcomes in terms of morphological and histolopathological findings, as well as a lowered duration of lameness than the group that received saline injections, although there are no significant differences between the two groups. In addition, our study revealed that the groups that received combined injections of AOD9604 and HA showed better outcomes than the groups that received AOD9604 or HA alone. The apparently synergistic effect of combined injections is thought to indicate that intra-articular injection of HA may have a chondrocyte-protective role, and the AOD9604 could help recapitulate the developmental cascades which regrows a segment of the articular cartilage in a joint. Our results are consistent with those of a previous study [8] that combined the injection of HA with recombinant human GH and found that the combination is more effective than HA injection alone.
Our peptide therapies are also known as secretagogues – a substance that promotes secretion.  These amino acid chains communicate with the body to produce or release growth hormone.  The increased volume of human growth hormone produced by the pituitary gland causes an increase in the production of Insulin-Like Grow Factor-1 (IGF-1) by the liver and results in several health benefits such as:
For example, insufficient protein or calories can cause IGF-1 to plummet, while ample calories can cause IGF-1 to increase. For example, one study of women who fed with excess calories over and above their normal metabolic rate noted a 19% increase in IGF-1 after two weeks of overfeeding, with 46% of the weight gain from  lean mass and 54% from bodyfat. Fasting insulin doubled in these women, and testosterone levels also significantly increased.
Ipamorelin is a man-made peptide that is part of the growth hormone family. Rated as one of the safest in the peptide industry, it has strong growth hormone releasing properties. From this, it is a huge winner with athletes and bodybuilders. This is because it builds muscle and keeps weight down quickly. It works by sending signals to the pituitary gland at the base of the brain and adjusts and controls various body functions through the endocrine system. It binds certain receptors inside cells. This allows cells to respond and change, encouraging growth and regulation of hormones. Ipamorelin can help with:

Tissues from ob/ob and lean mice were cut into 100-mg pieces and homogenized with 1 ml TRIzol (Life Technologies, Inc., Grand Island, NY) using a PolyTron homogenizer (Kinematica, Lausanne, Switzerland). The samples were incubated for 5 min at room temperature to permit the complete extraction of the RNA from the tissues. An aliquot of 0.2 ml chloroform was added to each milliliter of TRIzol. The method of RNA extraction was as described by the manufacturer (Life Technologies, Inc.). The final RNA pellet was air dried for 5–10 min and then resuspended in 20 μl ddH20. RNA was quantitated spectrophotometrically using the A260/280 ratio.


Serum IGF-1 levels remained relatively constant over the dosing period with no apparent differences between treatment groups. Fasting plasma glucose and serum insulin levels remained unchanged throughout the treatment period. Furthermore, no changes in any of the OGTT parameters were observed from day 1 to day 7 of treatment. There were no study related clinically significant findings in the safety related laboratory tests, vital signs, or ECG measurements.

From this study it appears that the β3-AR is an important contributor to the effects observed on body weight in obese mice treated with AOD9604 and hGH. To determine whether theβ 3-AR is partly responsible for this effect, we examined the effects of AOD9604 and hGH in theβ 3-KO mouse. The β3-KO mouse is not grossly obese, but female mice have increased fat depots (21) and the mice do develop late-onset obesity (Summers, R. J., personal communication). AOD9604 and hGH increased body mass and decreased BAT mass in the WT strain but had no effect in the KO animals. In WT mice, plasma glycerol was increased in response to AOD9604 and hGH treatment (4 wk). However, in the KO mice, only hGH resulted in increased levels of glycerol in the KO mice, and this effect was significantly less than that observed in the WT mice. This suggests that the regulation of the β3-AR is essential in the ability of AOD9604 and hGH to mediate chronic effects on lipolysis and fat mass reduction.


Echocardiographic measurements obtained at pre‐ and post‐bypass visits are outlined in Table 2. Due to limitations in scanning windows and poor image quality, interpretable echocardiograms were obtained in 12 of 15 patients. Transmitral E increased from 76±19 cm/s at pre‐bypass to 83±19 cm/s at the post‐bypass surgery visit while no significant increase was noted in transmitral A. The mean intra‐individual change in transmitral E was 15 cm/s, with 95% confidence interval 3 to 26 cm/s. The increases in transmitral E were significant for the effects of saline (P=0.005) and surgery (P=0.002). There was also a significant increase in the early diastolic mitral annular velocity e′ (P=0.02 for effect of surgery). However, the E/e′ ratio did not change after surgery (Table 2). Left atrial diameter showed a trend towards decrease at the post‐bypass surgery visit (P=0.3).


Ipamorelin, like other growth hormone peptides, is used to increase production of your own growth hormone levels. Growth hormone levels are at their peak in our twenties, and then gradually decrease with age. There are a few different peptides including Sermorelin, GHRP2, GHRP6, and Ipamorelin. These peptides are listed in order of how recently they have been developed, with Ipamorelin being the newest and most commonly recommended.
Mod GRF 1-29 and CJC-1295 are still being researched. As such, they are not yet medically utilized or approved. Though some firm protocols for the use of these peptides have been developed, the dosage of the compound is not yet medically confirmed. In a study conducted by researchers on 21 to 61 year-old subjects, it was found that depending on the dose, the concentrations of the growth hormone increased to up to 10 times for at least 6 days. Also, the concentration of IGF-1 increased to up to 3 times for 9 to 11 days.
Another side effect of the CJC-1295 is acromegaly, since it helps in increasing the levels of the growth hormone. Acromegaly is a condition where extra growth hormone is released even after the internal organs and the skeleton have finished growing. This causes thickening of the skin, deepening of voice, enlargement of jaws, and slurring of speech. Another effect of acromegaly is the swelling of the soft tissue in the internal organs. This could result in the weakening of the muscles of the internal organs, like the heart. This was tested during the phase 2 testing of CJC-1295.
The male β3-KO mice and wild-type (WT) that were used in this study were offspring of animals provided by Dr. Bradford Howell (Beth Israel Hospital, Harvard Medical School, Boston, MA). The animals were bred and housed in the central animal house facility (Monash University). For chronic studies, animals were housed in the Departmental Animal Facility (Biochemistry, Monash University). For acute energy expenditure studies, animals were transported to the Department of Medicine (University of Melbourne), acclimatized, and killed following experimentation. The WT andβ 3-KO mice genotype were verified by breeding records and RT-PCR analysis performed in the laboratory of Professor Roger Summers.
Cartilage loss in OA is caused by proteoglycan depletion and chondrocyte death that in turn are caused by imbalances between catabolic and anabolic activities within the joint [5]. Growth hormone (GH) has been shown to correct this imbalance [6]. Although the exact mechanism underlying the effects of intra-articular GH injection is not known, GH in the synovial fluid probably enhances proliferation, matrix synthesis, and differentiation of bone and cartilage cells in vitro [7]. Studies have found that GH accelerates healing in animal models of OA [8,9]. However, intra-articular GH injections in humans are known to have detrimental pro-tumor and pro-diabetic effects. These negative effects are caused by the secondarily produced insulin-like growth factor-1 (IGF-1) [10].
The known side effects of IGF-1 injections include jaw pain, facial and hand swelling and heart-rhythm disturbances, especially if doses of more than 100 micrograms (mcg) are injected. Exceeding 100mcg of IGF-1 can actually cause your heart to stop beating and blood pressure to drop dramatically. This is caused by an IGF-1-induced drop in blood phosphate levels, and in the bodybuilding community is often prevented by administering phosphate with the IGF-1.
As in the previous study there were no clinically relevant changes observed in safety laboratory parameters 24 hours following administration of AOD9604 or placebo. Similarly, there were no clinically relevant changes in vital signs (blood pressure, radial pulse rate and temperature) or ECGs recorded at any of the scheduled time points up to 24 hours post dose. There were no significant changes in glucose or IGF-1 levels following AOD9604 treatment compared with placebo.
The levels of plasma glycerol were determined according to the method previously described (8) and expressed as a change from d 0 values. The amount of glycerol present in the plasma was enzymatically assayed using glycerol phosphate oxidase reactions (catalog no. GPO-337, Sigma Diagnostics, St. Louis, MO). Plasma glycerol was determined using a spectrophotometer and converted to micromoles per deciliter.

AOD9604, a synthetic fragment of hGH consisting of the amino acid residues 177–191 with the addition of a tyrosine residue to the N-terminus was prepared with solid-phase synthesis procedure and purified with reverse-phase HPLC methodology in our laboratories (13). The structure of the peptide analog was verified with mass spectrometry and amino acid analysis. The hGH was a gift of Professor Michael Waters (University of Queensland, Brisbane, Australia). BRL37344 (β3-AR agonist) was a gift from Dr. Jon Arch (SmithKline Beecham, Harlow, UK).

As both CJC1295 and Ipamorelin bind to the pituitary gland and prompt the release of GH, when used together, the production of growth hormone is over 10 times more than when used individually. As it stimulates the body’s natural growth hormone production it also causes the release of IGF-1. The advantages of the CJC peptide is that it helps increases bone density and collagen, as well as boosting the immune system. It will also produce new muscle cells which will be leaner and increases weight loss. The CJC 1295 results are part of years of scientific studies. It primarily increases the production of proteins, which leads to stable bodily functions related to the glands in the body or the endocrine system.
Whilst AOD9604 is not approved by the Australian TGA, it can be legally obtained on a doctor's prescription and dispensed by a compounding pharmacy (2). This is true of many experimental substances, but it does big favours for the reputation of AOD9604, giving the impression that, like other drugs issued by the medical profession, it is an efficacious and high quality product. These reasons, when considered together, give a powerful impression that peptides are highly effective – they wouldn't ban them for no reason, would they?
A large difference between steroid hormones and peptide hormones is that some steroid hormones exhibit oral activity, in that they can be active after they are taken by mouth. However, many peptide hormones are digested in the same way as proteins. They are broken down into amino acids in the digestive system, which means they no longer have the bioactivity of their parent compound. Consequently, they may require administration through injections.
There were no significant changes in IGF-1 values observed during 24 hours following any AOD9604 dose compared with placebo. No significant differences in glucose levels were observed following AOD9604 administration compared with placebo with the exception of one isolated time point (8% increase 12 hour post treatment in one subject receiving 54 mg AOD09604). There were no clinically significant observable trends in vital signs, physical examinations, abnormalities noted in the ECG measurements, or findings in the safety-related laboratory tests throughout the study.

In summary, our study provides evidence of an alteration in the natriuretic peptide “set point” with weight loss. These findings highlight the potential role of a “natriuretic peptide deficiency” in obesity‐related conditions such as hypertension and heart failure. One can further speculate that reversal of the “natriuretic peptide deficiency” could play a role in the improvement of blood pressure and cardiac function after weight loss.
I have a close friend that's wanting to drop some fat before his wedding and honeymoon , I've had him on a solid diet and training regimen for a month now and he is making good progress but I don't think he's gonna be on track with where he wants to be in time. Rather than have him use clen or DNP I'd rather have him use a peptide or something safer.
But let’s say you’ve already implemented the IGF-1 boosting strategies of adequate calories, sufficient protein, weight training, plenty of sleep, smart supplementation, mineral intake and alcohol moderation. Should you take the next step, wander into an anti-aging clinic, find an online pharmacy, lurk in the depths of bodybuilding forums, and begin IGF-1 injections?
Another benefit of collagen supplementation to your workout routine? Collagen contains high amounts of the amino acid arginine, which changes into nitric oxide to help our blood vessels relax and promote healthy circulation. Additionally, arginine has been found to help promote total strength and recovery in adult males (4). Adding collagen into your daily diet can help keep your bones strong, helping you to stay active and healthy.
For CJC-1295 DAC there are no particular diet restrictions that need to be followed due to its long half-life. For GHRP products the following should be observed as insulin and fatty acids can blunt the release of GH in the body and therefore make your injections less effective: •Avoid eating/drinking anything high in fat for 3 hours before your injection and anything high in carbohydrates for 1-2 hours (always do your injection on an empty stomach). •Wait at least 20 minutes after your injection before eating/drinking anything with calories.
If muscle gain is not what you’re looking to gain, then the best place to start is by getting your hands on some CJC-DAC and administer at 2-5mg per week. CJC-1295 with or without DAC is suitable. An equally effective alternative is GW501516. Peptide Clinics Australia recommend Oxytocin for weight loss highly and they’ve had amazing results from patients that have been prescribed this.
From this study it appears that the β3-AR is an important contributor to the effects observed on body weight in obese mice treated with AOD9604 and hGH. To determine whether theβ 3-AR is partly responsible for this effect, we examined the effects of AOD9604 and hGH in theβ 3-KO mouse. The β3-KO mouse is not grossly obese, but female mice have increased fat depots (21) and the mice do develop late-onset obesity (Summers, R. J., personal communication). AOD9604 and hGH increased body mass and decreased BAT mass in the WT strain but had no effect in the KO animals. In WT mice, plasma glycerol was increased in response to AOD9604 and hGH treatment (4 wk). However, in the KO mice, only hGH resulted in increased levels of glycerol in the KO mice, and this effect was significantly less than that observed in the WT mice. This suggests that the regulation of the β3-AR is essential in the ability of AOD9604 and hGH to mediate chronic effects on lipolysis and fat mass reduction.
There are thousands of weight loss programs to choose from. A Google search for how to lose weight returns over 97 million results. With so much information out there, it’s easy to get overwhelmed or confused. Especially since most of the information you come across on weight loss is completely false. There are gimmicks and bad advice that lead desperate dieters down the wrong path, and the only measurable result is the decrease in the weight of your wallet!

To amend Schedule 2 entry to exempt paracetamol when compounded with caffeine, in a powder or granule product containing 1000mg or less of paracetamol and in tablets or capsules containing 500mg or less of paracetamol when paracetamol is the only therapeutic active constituent and when supplied in primary packs of not more than 20 tablets/caplets or 10 sachets of powders/granules.
No growth hormone, or any supplement for that matter, is never going to equate to the same exact results for every user. So, what you experience, is not the same as the next user, and vice-versa. Further, the increase in results and how quickly you will see these results are going to differ for each user. So, make sure you understand this prior to start your dosage, to ensure you are not disappointed if you do not see each one of these benefits, on the very first day that you begin using the Ipamorelin. Also consider the fact that if you use it after food, or with a meal, results will improve. So, proper timing and proper diet and exercise regimen can greatly enhance the results you are going to realize when you are using Ipamorelin as well.
I have questions about combined therapy of CJC 1295 and Ipamorelin at the same time on a daily basis for both. The compounding pharmacies do not clearly state whether the CJC is with or without DAC. If it is the CJC with DAC, which sustains elevated GH and IGF-1 for several days, would taking it nightly in conjunction with the Ipramorelin, that is suggested to be taken TID but is being recommended only once at night, be over-stimulatory? If the CJC is without DAC, why take two pepetides simultaneously ,that have similar effects? I am just not clear why taking a daily dose of CJC with Ipamorelin as a single dose is better than taking the CJC with DAC twice per week alone or take the CJC with DAC for a while then switch to the Ipamorelin for a while?
The test substance was either administered intravenously (studies METAOD001 and METAOD002) or as a capsule/tablet. The hexadecapeptide AOD9604 was produced under cGMP conditions by PolyPeptide Laboratories (Torrance, CA, USA). For studies 1 and 2, the product was supplied in a lyophilized form and reconstituted before usage with the designated volume of sterile water for intravenous injection. The capsules/tablets were manufactured using a common excipient mix (Capsules: Mannitol, PEG3350 (in studies METAOD003, METAOD004 and METAOD005)); or Tablets: L-Arginine Free Base, Microcrystalline Cellulose, Fumed silica, Magnesium Stearate (in study METAOD006)).
AOD9604 is a peptide (a chain of amino acids) which was developed and patented by a company called Metabolic Pharmaceuticals in Australia in the late 1990s. AOD stands for "Anti Obesity Drug". This peptide has an amino acid sequence that mimics the lipolytic region of human growth hormone (the region of this hormone thought to be responsible for burning fat) and it has been promoted variously as a weight loss supplement, as an aid to muscle and cartilage repair, and a treatment for osteoarthritis by its manufacturers. It is also known as lipotropin and Tyr-hGH fragment, and is generally available these days as a transdermal cream or an injectable.

Simply Vital is an online service that acts as an agent between the customer and "Initially we were inundated by men wishing to find a way to add muscle quickly, but now in excess of 60 per cent of our weekly orders are women wanting products to help with results ranging from fat loss and anti-ageing to general well-being," says owner Michael Abdallah.
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