Figure 2A shows that neither hGH nor AOD9604 had any significant effect on the weight of epididymal adipose tissue in the lean mice. However, in the ob/ob mice, AOD9604 induced a 28% decrease in epididymal adipose tissue mass, and hGH induced a 40% reduction in epididymal adipose tissue mass (P < 0.05). Brown adipose tissue weights were also measured (Fig. 2B). In this tissue, both AOD9604 and hGH induced a reduction in the weight of brown adipose tissue in both the lean and ob/ob mice.
Lean C57BL/6J and obese (ob/ob) mice aged 12 wk were used in this study. There were 18 mice in each group, and they were divided into three treatment groups [saline (n = 6); AOD (250μ g/kg·d; n = 6); hGH (1 mg/k·d; n = 6)]. The animals were housed in the Departmental Animal Facility at a constant temperature and humidity in a 12-h light, 12-h dark cycle. Animals were injected with a single intraperitoneal dose of saline, AOD9604, or hGH at 0800 h each day for 14 d using a 1-ml syringe and 23-gauge needle. The body weights of the animals were recorded every second day along with food intake.
Phenylephrine is readily eliminated by sulphate conjugation in the intestinal wall, and oxidative deamination by monoamine oxidative glucuronidation in the liver. Monoamine oxidase (MAO) inhibitors can enhance the limited potential of phenylephrine for cardiac and pressor effects, by reducing metabolism. As a largely specific alpha adrenergic drug, with very weak beta agonism, there is little direct cardiac effect. However, in higher doses, there can be increases in both systolic and diastolic blood pressure and a reflex bradycardia. As an adrenergic agonist there is the potential to interact with other sympathomimetic drugs. In overdose phenylephrine can cause hypertension, headaches seizures tachycardia, and vomiting. There has been no evidence from carcinogenicity studies in rodents of any enhanced cancer risk over prolonged exposure.
The expression of β3-AR RNA was assessed by RT by using radiolabeled primers and Southern blot analysis. Labeled bands were identified and semiquantitated by phosphorimaging. RT-PCR analysis demonstrated that ob/ob mice express lower amounts ofβ 3-AR RNA in their white (Fig. 3A) and brown (Fig. 3B) adipose tissues, compared with lean C57BL/6J mice, in agreement with others (14). Figure 3A shows the effect of saline, AOD9604, and hGH on β3-AR RNA expression in epididymal adipose tissue from both lean and obese mice, respectively. The level of β3-AR expression increased significantly in response to AOD9604 and hGH only in the obese mice, correlating with the significant decrease in epididymal adipose tissue weights seen in these mice. The same correlation was observed in brown adipose tissue, where increased expression of β3-AR was accompanied by a decrease in brown adipose tissue mass in both lean and obese mice (Fig. 3B).
Peptides are not to be confused with synthetic human growth hormone drugs, which are injected into the bloodstream to provide rapid results. HGH is said to be Hollywood's secret weapon, with top stars, filmmakers and studio execs hooked on the youthful effects, but synthetic hGH is tightly regulated in Australia and verboten unless there's a proven growth hormone deficiency (most cases are in children).

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The lateral and medial condyles of the femur and tibia were fixed with 10% neutral buffered formalin and decalcified with 20% ethylenediaminetetraacetic acid (EDTA). Calcified condyles were embedded in paraffin, and standard frontal sections of 5 μm were prepared and stained with haematoxylin and eosin in the cartilage of the lateral part of the femoral condyle, according to gross morphological observations [14]. If the staining was not adequate, the specimen was cut at the next cartilage surface. Cartilage degradation features were analyzed using the scoring system modified by Mankin et al. [14]. Histopathological evidence of cartilage degeneration was evaluated by structural scoring (0, normal; 1, surface irregularities; 2, pannus and surface irregularities; 3, clefts to transitional zones; 4, clefts to radial zones; 5, clefts to calcified zones; and 6, complete disorganization) and cell status (0, normal; 1, diffuse hypercellularity; 2, cloning; and 3, hypocellularity) of the articular cartilage. Total score ranged from 0 (normal) to 9 (complete disorganization and hypocellularity of the articular cartilage). All sections were graded by two independent pathologists who did not have any information about the injection solutions.
AOD9604: AOD9604 is a synthetic peptide taken orally. The small peptide mimics a section of the growth hormone molecule which increases fat metabolism and decreases the production of fat. AOD9604 is claimed to reduce fat, increase muscle mass and possibly help recover from joint cartilage damage. However, there is currently no published human data to support these claims. AOD9604 is not approved for human use, but is used in sport for weight loss and muscle enhancement and the perception that it helps recover from tissue damage. This drug was highlighted in the Australian Crime Commission report on Organised Crime and Drugs in Sport. No significant adverse effects have been reported yet, but AOD9604 is now prohibited by WADA.
Ipamorelin stimulates the pituitary gland to produce more endogenous growth hormone. This means your body’s Ipamorelin levels naturally grow, rather than simply adding synthetic growth hormone into your system. This stimulation is much more selective with Ipamorelin, especially compared to older peptides like Sermorelin. For patients, this means Ipamorelin has more benefits with fewer side effects.
Peptides are a generic name given to any group of amino acids that are linked together to form a chain. Essentially, they are similar to proteins, though in much shorter lengths (less than 50 units long). In the world of bodybuilding and exercise science, peptides generally refer to one of two things. They can refer to either broken protein fragments from hydrolysed proteins, or peptide hormones and related compounds.
Depending on the intended use, and your desired results, the dosage levels are going to vary from person to person as well. So, keep this in mind when trying to determine how great the results are actually going to be when you are using Ipamorelin. So, what exactly can you expect when using this supplement? Some things you will see, for every user is:
I stopped the colostrum and my ” symptoms ” subsided, seems I have a moderately enlarged prostate which doesn’t run in my family on either side, my question is could the colostrum possibly cause the prostate to enlarge due to the igf-1 at a certain age,? due to a possible decline in testosterone, or could the benefits of colostrum outweigh the prostate issue?
Figure 2A shows that neither hGH nor AOD9604 had any significant effect on the weight of epididymal adipose tissue in the lean mice. However, in the ob/ob mice, AOD9604 induced a 28% decrease in epididymal adipose tissue mass, and hGH induced a 40% reduction in epididymal adipose tissue mass (P < 0.05). Brown adipose tissue weights were also measured (Fig. 2B). In this tissue, both AOD9604 and hGH induced a reduction in the weight of brown adipose tissue in both the lean and ob/ob mice.
Steve Coggan, Chatswood, Sydney, “I am 48 and been weightlifting for 20 years. I have used CJC 1295 and Ipamorelin on their own and together, and have to say that when combining them they work better and faster. I have been using them for the past year, with 2 rest times. The combination of CJC 1295 Ipamorelin, is proving fantastic all round. Not only am I increasing muscle, my weight is down, but my skin is looking great. Some of the bags under my eyes have more or less gone. My missus thinks I look 10 years younger! Also, it has helped in the recovery of an injury to my knee after a fall. I have to say it isn’t cheap, but the results are worth it. CJC 1295 Ipamorelin side effects were few, just some headaches at first. You need to use it with a good diet and fitness regime for best results. I will definitely be continuing with it!”
The two peptides CJC 1295 Ipamorelin, are often used in conjunction for better results. Known individually as CJC 1295 and Ipamorelin, these peptides have similar roles, which we will look at later. But for now, the CJC 1295 and Ipamorelin combination, is chiefly used together because the production of growth hormone secretion is 10 times more effective than using them individually. This makes it convenient for most users, to guarantee quicker results. Above all, it is popular among athletes, bodybuilders and weightlifters in need of building strength or speeding up the recovery of an injury.
Obesity is the Western World’s most common health problem, and has reached epidemic proportions according to the World Health Organisation. More than 20% of the adult population in developed countries are obese – more than 300 million adults worldwide. In addition, more than 50% of adults in developed countries are overweight. Obesity is associated with other health-related problems such as heart disease, cancer and diabetes.
All studies were performed according the Declaration of Helsinki (as amended in Edinburgh, Scotland, October 2000) and the ICH Guidelines for Good Clinical Practice (GCP) (E6). Further, independent ethics review committees of up to 16 Australian hospitals and medical centers have approved each of them. The two largest studies (METAOD005 and METAOD006) were registered at the Therapeutic Goods Administration’s Clinical Trial Notification (CTN) Scheme in Australia.

Several epidemiologic studies have reported lower circulating natriuretic peptide concentrations in obese individuals.12, 14 However, these studies have been observational and confined to a single time point of measurement of natriuretic peptides. To our knowledge, only one previous study has examined the association of obesity with salt‐induced natriuretic peptide concentrations. Licata and colleagues found reduced, salt‐loaded plasma ANP concentrations in 9 obese individuals compared with 10 lean controls.21 They did not examine the influence of weight loss on the natriuretic peptide system. Thus, the present study is the first to provide serial, physiologic data from the same individuals over time.
In addition, scientists have observed that those who supplemented with IGF-1 experienced a preponderance of new brain cell growth and new muscle mass and new studies confirmed this to be true, even among individuals with both brain damage and muscle-wasting sarcopenia. Furthermore, research studies have found IGF-1 to increase feelings of youthfulness, improve well-being, and even to alleviate depression.
AOD9604 is a peptide fragment (hGH Fragment 177-191) of the C-terminus of Human Growth Hormone to which a tyrosine is added at the N-terminal end.  Studies have suggested that AOD9604 is more effective than its predecessor AOD9401 in its ability to stimulate lipolytic (fat burning) and anti-lipogenic activity. Like Growth Hormone, AOD9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (prevents the transformation of  fatty food materials into body fat) both in laboratory testing and in animals and humans.  Recent  clinical research studies have shown that  AOD9604 did show a reduction of body fat in the mid abdominal area in both obese, over-weight, and average built people.

Like everything in life, you need to be careful. Too much of a good thing can be bad. Water and oxygen are essential for survival, however in excessive amounts be prepared to have ‘000’ on standby. The same principal is true for any drug or peptide. When used at the recommended dose, clinical trials have proven peptides to be effective with minimal side effects, if any. In addition, the body even has its own natural feedback mechanisms in place to downregulate high levels.

Comparing everything else is hard due to branding... don't want to start going into branding for obvious reasons. GH is incredible for fatloss but some brands add so much water it is hard to see the results to begin with. But due to the high serum and igf-1 from gh excellent results are to be had. Many factors come into play though which I am sure your well aware of. I think the ghrp's (2 and 6 for example) are excellent for fatloss if you keep up with the 4 daily injections in your research. Otherwise they are nowhere as effective due to the short peak times... so one must be organized and disciplined to get the full benefits.
For example, if 100mcg more were to be administered after the first 100mcg (making the effective dose of 200mcg), then the second dose will achieve only 50% of what the first dose already did. A 100mcg more (making a total of 300mcg) will achieve only 25% more of the initial dose. This implies that, in order to increase the effect of the compound, only a little more of it can be successfully administered after the saturation dose.
Fenphedra could have easily been our #1 rated diet pill for women if not for its safety concerns. There have been rumors Fenphedra contains phentermine and prescription-strength pain relievers. Any rumors of such claims are completely false, but Fenphedra does contain phenylethylamine. Often referred to as the “Love Drug,” phenylethylamine is extracted from cocoa and responsible for the “chocolate high” sensation. Fenphedra also contains Green Coffee Bean, Chromax and Dicaffeine Malate, which dramatically burn fat, suppress appetite, and increase energy. Finding bottles of Fenphedra in the U.S. can be difficult because rumors are flourishing that it may be taken off the market like banned diet pills for women. Fenphedra retails for $130 per bottle and comes with a 100% money-back guarantee. The cheapest place to buy online occasionally has bottles available for as low as $69.95. Read More
Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 177-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural Growth Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormone.
also using a dose of 400mcg for the IPAM is really a waste of your peptides as anything above saturation dose will give diminished returns, saturation dose(1mcg per kg) is a dose that will give maximum return, if you double the saturation dose then you will not get double the GH pulse in fact no where near that, then the more you use the less added benefit you will get.
The increase in GH secretion due to IPAMORELIN (and other GHRP) leads to an increase in IGF-1 (thought to be the anabolic mechanism of GH).  As we get older GH and subsequently IGF-1 decrease substantially.  This decline is thought to be one of the major causes of the ageing process.  By increasing these levels again there is increased collagen synthesis, promotion of lean muscle mass, bone strength, improved healing capability, improved sleep cycle, increased energy, repair and regeneration of internal organs, strengthening of joints/cartilage/connective tissue, and anti ageing effects on the skin. 

The biggest negative, and this is a big one, is that AOD9604 has undergone very rigorous scientific testing, and has been found to have no effect in humans (3). When AOD9604 was first developed, it showed significant promise as a weight loss treatment. A special strain of obese mice supplemented with the peptide showed a reduction in weight, increased fat oxidation, and raised plasma glycerol, which are indicators of lipolysis, or fat burning (5). Subsequent studies in obese mice and rats attempted to show that the peptide works to burn fat in the same way as human growth hormone, but found that this was not the case, meaning that the fact this peptide resembled hGH was meaningless. Scientists were unable to determine how this peptide was working in mice (6).
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As simple and basic as it is, eating less calories is much harder in practice than it sounds. Ask anyone who has ever gone on a diet before! Everyone knows if you want to lose weight, you need to eat less. It’s the first step of any legitimate diet and fitness program, but how much less, and what to eat remains a mystery to many dieters. Or, the results don’t come quickly enough and the dieter gives up before real results are experienced.
IGF-1 Peptides: include IGF-1 LR3 and IGF-1e (also known as MGF or Mechano Growth Factor). IGF-1 is responsible for many of the positive effects of GH on fat loss and muscle building therefore they offer a good addition, especially if your goal is to build muscle, as they are both responsible for creating new muscle cells which can hypertrophy (get bigger) through weight training.
Results: After a single injection of CJC 1295, there were dose dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 d or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9–11 d. The estimated half-life of CJC 1295 was 5.8–8.1 d. After multiple CJC 1295 doses, mean IGF-I levels remained above baseline for up to 28 d. No serious adverse reactions were reported.
Like everything in life, you need to be careful. Too much of a good thing can be bad. Water and oxygen are essential for survival, however in excessive amounts be prepared to have ‘000’ on standby. The same principal is true for any drug or peptide. When used at the recommended dose, clinical trials have proven peptides to be effective with minimal side effects, if any. In addition, the body even has its own natural feedback mechanisms in place to downregulate high levels.
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