Gamma-Oryzanol (γ-Oryzanol): An antioxidant extracted from rice bran oil, wheat bran and some fruits and vegetables, γ-Oryzanol has been used as an alternative medicine in the treatment of high cholesterol, symptoms of menopause and ageing, mild anxiety and stomach upsets. Although it is used in sports to apparently increase testosterone and growth hormone levels, as well as improving strength during resistance exercise training, there is not enough evidence to determine its effect on hormone levels in humans. Even though animal studies suggest that γ-Oryzanol might actually reduce testosterone production, it has been marketed to, and used by, body builders and strength-training athletes in the hope of boosting strength, increasing muscle gain, reducing body fat, speeding recovery and reducing post-exercise soreness. γ-Oryzanol is not banned by WADA.
Peptide supplementation is fast becoming Australia’s solution to a variety of health, fitness, and age-related concerns. Peptides have been around long before the recent media brought it to our attention through use in elite sport. The simple science of amino acids linked together, via peptide bonds, brings to life this now common word—peptides. Some of the benefits that peptides can assist you with during your journey to health and wellbeing include:
Osteoarthritis (OA) is a degenerative joint disease that results from articular cartilage loss induced by complex interactions of genetic, metabolic, biochemical, and biomechanical factors with secondary components of inflammation . OA is the most common arthritis and a major medical problem in people aged 65 years and older . Non-steroidal anti-inflammatory drugs (NSAIDs), physical therapy, exercises, corticosteroids, and hyaluronic acid injections have all been used for the conservative treatment of OA. The role of NSAIDs in OA management is controversial because of its adverse side effects, as well as side effects on the cartilage .
In June 2007, the NDPSC decided to extend the exemption from the limit on paracetamol combinations being allowed as general sale products to include phenylephrine (as long as it also qualified as exempt from scheduling through the phenylephrine entries). At that time, the NDPSC considered that the safety profile of these substances was such that allowing a fixed combination to be unscheduled was reasonable.
All our peptides are prescribed by experienced anti-ageing doctors, and arrive directly to you from the pharmacy. The prescription will include your name, product name, dose, and potency. The product arrives cold packed and reconstituted, ready to use. All of our peptides that are in injectable form also come with the syringes and swabs needed to complete your course.
For example, studies have shown that people deficient in IGF-1 have an increased chance of dying from a heart attack. This is because IGF-1 prevents the death of heart cells and offers protection to heart cells when the cells are stressed, such as during a heart attack or long amount of time without oxygen. IGF-1 has a similar protective effect on brain cells.
Cerebrolysin: A mixture of peptides extracted from pig brain that supports the development and function of nerve cells, cerebrolysin can be used to treat Alzheimer’s disease and vascular dementia but because the drug needs to be injected daily, it doesn’t have a clear benefit over existing oral medication. It’s not known to have any major side effects. In sports, cerebrolysin used to enhance mental function and “defog” the brain, although there is no good evidence that it has any effect in healthy individuals. It’s not currently listed as banned under WADA, either directly or via similarity of mechanism to banned peptides.
An important component of losing weight and staying healthy is being active-whether by going to the gym or even just walking regularly. To stay active, we need to make sure our bodies stay strong, as well as avoid injuries or other aches and pains that may prevent us from working out. Collagen supplementation can help. Adding collagen protein into your daily diet can help support your bones and joints. In a 24-week study, researchers observed the effect of collagen hydrolysate supplementation on exercise related joint pain on 97 human athletes. The researchers found that collagen supplementation can reduce joint pain (3). Therefore, adding collagen into your daily routine can help in your weight loss plan by preventing pain and joint injury arising from physical activity and exercise.
AOD9604: AOD9604 is a synthetic peptide taken orally. The small peptide mimics a section of the growth hormone molecule which increases fat metabolism and decreases the production of fat. AOD9604 is claimed to reduce fat, increase muscle mass and possibly help recover from joint cartilage damage. However, there is currently no published human data to support these claims. AOD9604 is not approved for human use, but is used in sport for weight loss and muscle enhancement and the perception that it helps recover from tissue damage. This drug was highlighted in the Australian Crime Commission report on Organised Crime and Drugs in Sport. No significant adverse effects have been reported yet, but AOD9604 is now prohibited by WADA.
The weight lost by the 1mg group was slightly more than that achieved by the world’s largest selling prescription obesity medication in similar trials over the same period, without its troublesome side effects. The trial results also demonstrated a small but consistent improvement in cholesterol profiles, and a reduction in the number of patients with impaired glucose tolerance.
The four groups showed different gross morphological damage and histopathological changes in the cartilage of the lateral part of the femoral condyle (Figure 3). Complete disorganization of articular cartilage with apparent cloning of chondrocytes in the transitional and radial zones was evident in Group 1 (Figures 3-A,E,I). Abnormal gross morphological and histopathological changes such as fibrillated and irregular cartilage surfaces, disappearance of surface-layer cells, and slightly diffused cell growth in the transitional and radial zones were observed in Group 2 (Figures 3-B,F,J). Erosion of the articular cartilage, cleft, and cell cloning in the transitional and radial zones were noted in Group 3 (Figures 3-C,G,K). Softening of articular cartilage and surface irregularities were noted in Group 4 (Figures 3-D,H,L).
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You’ve already learned that sufficient protein intake (above 0.5g/lb of body weight) can assist with adequate IGF-1 and growth hormone production. Whey protein provides your body with a complete profile of necessary amino acids, including leucine. Leucine is an amino acid that promotes greater muscle protein synthesis and assists the body while gaining lean muscle mass and losing fat tissue simultaneously.
Growth Hormone (GH) exhibits its muscle building effects mainly after its conversion to IGF-1 (Insulin-Like-Growth Factor). This makes IGF-1 an ideal choice of peptides for muscle building, especially since the IGF-1 LR3 version has an extended half-life which allows it to remain active in the muscles for many hours to complete its muscle building stimulatory effects. Likewise, if injected after a workout, the IGF-1 variant Mechano Growth Factor (also known as MGF or IGF-1e) is known to multiply muscle cells and contribute to muscle development. Furthermore, since IGF-1 is a by-product of GH, any peptide which increases levels of GH in the body such as a GHRP product or CJC-1295 product will obviously lead to increased lean muscle mass.
There were concerns regarding the number of contraindications and precautions and whether consumers would be able to interpret these appropriately without a requirement for pharmacist advice. There were concerns regarding gastro-intestinal, renal and other adverse effects related to the potential interactions of ibuprofen and paracetamol. Also raised were concerns regarding the potential for paracetamol overdose.
It is not advisable to generalize our results for the OA in a rabbit model because of the small sample size of this study. Further studies with larger sample sizes and longer follow-ups are necessary to establish the validity of our results. Moreover, the different effects caused by varying intra-articular dosages, formulations, and injection intervals need to be assessed.
Now that I’ve told you about the benefits of collagen supplementation and how it can help in weight management, you may want to know which collagen supplement to use. There are a lot of collagen supplements out there, and I’ve tried most of them. I highly recommend you do your research to make sure you purchase one that contains no additional additives, flavors, or sweeteners. Also make sure the collagen has no hormones in it: look for collagen from grass fed and pasture-raised bovine or wild-caught fish. For those reasons, I recommend and Further Food Collagen Peptides - a brand I use and recommend to others.
Example 2 - Morning Injection ◦Wake up and inject your HGH Frag 176-191 (250mcg to 500mcg is a good dosage depending on your budget). ◦Wait as long as possible before having your first meal (the longer you wait the more fat you will burn). ◦When you do eat, try to make the meal high protein, low fat and low carbohydrate (example meat and salad/vegetables). ◦If possible, try to do some cardio in the hours after your injection to increase the fat burning effect.
After the commencement of the active treatment 88.9% of subjects experienced at least one AE, whereby the distribution was similar in the 5 AOD9604 groups and the placebo group. There was a higher incidence (48.4%) of nervous system disorders (mainly headache, 42.6%), gastrointestinal disorders (30.4%, mainly diarrhea unspecified, 9.0%) and infections and infestations (45.3%), than seen before the commencement of active treatment. The distribution of the intensity of AEs was similar across all treatment groups. The percentage of AEs that deemed to be possibly or probably related to the study medication was similar across all treatment groups, including placebo.
AOD9604 is a peptide (a chain of amino acids) which was developed and patented by a company called Metabolic Pharmaceuticals in Australia in the late 1990s. AOD stands for "Anti Obesity Drug". This peptide has an amino acid sequence that mimics the lipolytic region of human growth hormone (the region of this hormone thought to be responsible for burning fat) and it has been promoted variously as a weight loss supplement, as an aid to muscle and cartilage repair, and a treatment for osteoarthritis by its manufacturers. It is also known as lipotropin and Tyr-hGH fragment, and is generally available these days as a transdermal cream or an injectable.
To get the best results from your fat loss program and the highest fat loss amount from CJC 1295 Ipamorelin peptide supplementation, it is important to follow a diet that is rich in protein, low in carbs, moderate in the health fats while being physically active and doing cardio exercise as often as you can. Also, you need to keep your hormone levels properly balanced in order to boost your metabolism.
In this study, AOD9604 was given in a dose of 0.25 mg that is comparable to the dose used in a previous report  on GH in promoting recovery to normal walking and in joint repair in the rabbit collagenase model of osteoarthritis. AOD9604 is a fragment of GH; therefore the dose of AOD9604 used was the molar equivalent of the active GH dose that the previous study  used. Human GH was given as 3 mg in 0.6 ml intra-articular injection volume. On a molar basis, 3 mg of GH equates to 0.25 mg of AOD9604. In addition, published data  suggest that the volume of synovial fluid in an arthritic rabbit is approximately 0.7 ml. Combined with the injection volume, this gives a total volume of 1.3 ml and therefore an initial concentration of AOD9604 of 0.19 mg/ml. In a previous study  of GH in the beagle after intra-articular injection, researchers injected 1.5 mg of GH in aqueous solution in 0.15 ml volume. The aqueous formulation gave an initial concentration of approximately 200–300 ug/mL in the synovial fluid. On a molar equivalent basis this equates to 0.11 mg/mL of AOD9604, which is close to the value used in this study.
Obesity affects more than one‐third of US adults1 and is a major contributor to cardiovascular morbidity and mortality.2, 3 A significant proportion of the cardiovascular risk in obese people is attributed to the development of hypertension,4, 5 which predisposes them to increased risk of atrial fibrillation, coronary heart disease, and stroke.6 Abnormal salt handling is thought to be one of the mechanisms underlying obesity‐related hypertension.7, 8
For example, insufficient protein or calories can cause IGF-1 to plummet, while ample calories can cause IGF-1 to increase. For example, one study of women who fed with excess calories over and above their normal metabolic rate noted a 19% increase in IGF-1 after two weeks of overfeeding, with 46% of the weight gain from lean mass and 54% from bodyfat. Fasting insulin doubled in these women, and testosterone levels also significantly increased.
In this paper, we investigated whether the changes observed inβ 3-AR RNA expression in vitro also occur in an in vivo model. The in vivo model used was the obese (ob/ob) mouse model of obesity that has repressed levels of β3-ARs, which in part contributes to reduced lipolytic sensitivity (12). Lean C57BL/6J mice were used as a control. Following a 14-d chronic administration with AOD9604 or hGH, adipose tissue weights were measured, and β3-AR mRNA expression was determined. The decrease in weight of adipose tissue depots in the ob/ob mice was associated with increasedβ 3-AR expression. Further studies inβ 3-AR knock-out (β3-KO) mice showed that the presence of the β3-AR is necessary to mediate the chronic effectiveness of hGH and AOD9604 with regards to weight loss and fat mass reduction. However, an acute dose of AOD9604 was capable of increasing energy expenditure inβ 3-KO mice, although the response was less than that seen in the wild-type control mice.
The ACMS recommended that Growth Hormone Releasing Hormones (GHRHs), Growth Hormone Secretagogues (GHSs), Growth Hormone Releasing Peptides (GHRPs) as well as new individual substance entries for CJC-1295, ipamorelin, pralmorelin (Growth Hormone Releasing Peptide-2), Growth Hormone Releasing Peptide-6, hexarelin and AOD-9604 be included in Schedule 4.
Solcoseryl: Derived from calves’ blood and is believed to speed up healing of damaged or injured tissues, solcoseryl is currently used in humans as eye gel for corneal ulcers, a jelly/ointment for gangrene and bedsores, burns and wound healing, and inflammation of gums, lips and mouth ulcers. No major adverse effects been reported. Solcoseryl is not specifically banned under WADA as a substance but can potentially be banned as a method depending on how the substance is administered and how much is used.
The levels of plasma glycerol were determined according to the method previously described (8) and expressed as a change from d 0 values. The amount of glycerol present in the plasma was enzymatically assayed using glycerol phosphate oxidase reactions (catalog no. GPO-337, Sigma Diagnostics, St. Louis, MO). Plasma glycerol was determined using a spectrophotometer and converted to micromoles per deciliter.
•Avoid eating/drinking anything with calories for three (3) hours either side of your injection. •Try to make all your meals throughout the day high protein, low fat and low carbohydrates (eg. meat/fish with vegetables/salad). •Have as few meals as possible during the day as periods of fasting have been shown in many studies to improve fat loss and also longevity (i.e. eating less will make you live longer).
This particular peptide offers therapeutic benefits similar to those of hGH. CJC 1295 is a growth hormone releasing hormone (GHRH) analogue. In other words, it is a molecule that serves the same purpose as does GHRH—the hormone that stimulates the anterior pituitary to release hGH. However, unlike GHRH, which has a half-life of only minutes after IV administration, CJC 1295 is able to remain active in the body for extended periods due to its ability to bind to a protein in the blood known as albumin and avoid degradation by various enzymes. CJC 1295 increases an important growth factor, IGF-1, in addition to hGH, leading to fat loss, lean muscle growth, and enhanced sleep.
The interim decision was to include in Schedule 4 and in Appendix D Item 5 Growth Hormone Releasing Hormones (GHRHs), Growth Hormone Secretagogues (GHSs), Growth Hormone Releasing Peptides (GHRPs) as well as new individual substance entries for CJC-1295, ipamorelin, pralmorelin (Growth Hormone Releasing Peptide-2), Growth Hormone Releasing Peptide-6, hexarelin and AOD-9604.