The simple science of amino acids linked together, via peptide bonds, brings to life this now common word – “Peptides”. Used for a variety of health, fitness and anti ageing concerns, Peptides can help in many ways to promote fat loss, build lean muscle, assist with injury recovery, increase agility, and many other anti ageing benefits. Peptides are amino acid chains that act as messengers in the cellular world by telling your cells what to do. One of the world’s best kept secrets for optimal health is Human Growth Hormone (HGH). HGH is so instrumentally important that its decline as we age is directly related to our health and quality of life. Modern medicine is now recognising its decrease as a clinical syndrome called “Growth Hormone Deficiency Syndrome”. By stimulating your Growth Hormone levels back to a level that is clinically predicted for your age will allow your body to perform at its peak which allows you to feel youthful and rejuvenated.

In 2010, the company heard word that bodybuilders were importing knock-off versions of the patent-protected peptide from China, and started licensing the manufacturing rights out to other companies in an attempt to compete, as this was determined to be a better course of action than attempting to sue the Chinese company for patent breach (7, 8). Desperate to recoup this investment, they invested a small additional amount into developing a technology that allowed the peptide to be absorbed through the skin, in collaboration with a company called Phosphagenics (4). The peptide was then licensed for use in BodyShaper, an anti-cellulite cream. Phosphagenics later dropped AOD9604 from BodyShaper, citing excessive expense and ineffectiveness (3).
CJC-1295 is basically a peptide hormone that acts similar to growth hormone releasing hormones (GHRH). Invented by a Canadian biotechnology company called ConjuChem, it is beneficial to athletes because it can bioconjugate with circulating albumin and increase the time it can be used for medical purposes. It achieves this by preventing degradation of its amino acids. With a single dose, it can remain in the body for quite a few days and can cause the growth hormone to be released many times per day. This reduces the frequency of injections needed.
The ACMS recommended that Growth Hormone Releasing Hormones (GHRHs), Growth Hormone Secretagogues (GHSs), Growth Hormone Releasing Peptides (GHRPs) as well as new individual substance entries for CJC-1295, ipamorelin, pralmorelin (Growth Hormone Releasing Peptide-2), Growth Hormone Releasing Peptide-6, hexarelin and AOD-9604 be included in Schedule 4.
It is not advisable to generalize our results for the OA in a rabbit model because of the small sample size of this study. Further studies with larger sample sizes and longer follow-ups are necessary to establish the validity of our results. Moreover, the different effects caused by varying intra-articular dosages, formulations, and injection intervals need to be assessed.
In this study, AOD9604 was given in a dose of 0.25 mg that is comparable to the dose used in a previous report [8] on GH in promoting recovery to normal walking and in joint repair in the rabbit collagenase model of osteoarthritis. AOD9604 is a fragment of GH; therefore the dose of AOD9604 used was the molar equivalent of the active GH dose that the previous study [8] used. Human GH was given as 3 mg in 0.6 ml intra-articular injection volume. On a molar basis, 3 mg of GH equates to 0.25 mg of AOD9604. In addition, published data [10] suggest that the volume of synovial fluid in an arthritic rabbit is approximately 0.7 ml. Combined with the injection volume, this gives a total volume of 1.3 ml and therefore an initial concentration of AOD9604 of 0.19 mg/ml. In a previous study [11] of GH in the beagle after intra-articular injection, researchers injected 1.5 mg of GH in aqueous solution in 0.15 ml volume. The aqueous formulation gave an initial concentration of approximately 200–300 ug/mL in the synovial fluid. On a molar equivalent basis this equates to 0.11 mg/mL of AOD9604, which is close to the value used in this study.
To obtain the best results from a fat loss program, and the most amount of fat loss from your peptide supplementation, you should be following a diet which is high in protein, moderate in healthy fats and low in carbohydrates, and be physically active. At the very least you should be doing some high-intensity lifting a couple of times a week alongside the implementation of cardio. You should also have your hormone levels balanced to optimise your metabolism.
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This is cutting edge science and i freely admit is a PE...you could argue whey, bcaa or even intermittent fasting does the same thing, just not as refined hence the argument and confusion is that the substance is grey because the peptide stimulates natural GH which not even wada or asada know how to pidgeon hole it....its mostly unclassified...this is why we will be just fine... are you starting to see the glaring holes in your facts yet?
SARMs are selective androgen receptor modulators. Androgens are naturally occurring hormones—such as testosterone—that regulate the development and maintenance of male sex characteristics. SARMs provide the benefits of anabolic steroids (i.e., increased muscle mass/strength, fat loss, increased bone density, increased libido) without the quantity and/or severity of unwanted effects. SARMs are not toxic to the liver, separating them from most oral steroids and making them an attractive treatment option to those looking to benefit from anabolic steroid drugs.
Press coverage and word of mouth has generated quite a bit of hype around AOD9604. Despite its popularity on the black market, there is no research into the safety and effect of injecting this peptide at high doses. Intriguingly, it is not currently in Calzada's interest to fight the black market production of AOD9604, even though it is a patented product. Calzada lack the funds to legitimately boost the reputation of this peptide through clinical trials, and there is a strong chance these would once again prove that AOD9604 has no effect. The good reputation this peptide currently enjoys is likely to provide strong leverage to its marketing as a food supplement in the United States.
Peptides are defined as a compound of two or more amino acids in which a carboxyl group of one is united with an amino group of another. With the elimination of a water molecule, a peptide bond is formed. To put it more simply, peptides are just small proteins. When the number of amino acids are less than 50, these are peptides. When higher than 50, these are proteins. The peptides are therefore small chains of amino acid which are present in all cells of the body. There are several kinds of peptides: oligopeptides, polymers, proteins, neuropeptides and peptide hormones. These are synthesized naturally by the body. Peptides will therefore be used primarily to make a more abundant amount of hormones in the body. The latter will then produce new hormones such as Testosterone or corticosteroids. It is these two hormones that are considered anabolic or indirect anti-inflammatory.
Subjects were excluded if they had any of the following: history of myocardial infarction, heart failure, or left ventricular (LV) ejection fraction <50%, greater than mild valvular stenosis or regurgitation or any regional wall motion abnormalities by cardiac imaging, chronic renal failure or serum creatinine ≥3.0 mg/dL, atrial fibrillation, diabetes mellitus requiring insulin therapy, systolic blood pressure ≥170 mm Hg or diastolic blood pressure ≥100 mm Hg at the most recent weight center visit, a history of current loop or thiazide diuretic use, a history of obstructive lung disease, or thyroid dysfunction. Female subjects who were pregnant or planned to become pregnant within 6 months were also excluded. The Partners Human Research Committee approved the protocol. All subjects provided informed consent.
The medicines delegate referred the proposal to upschedule paracetamol/ibuprofen from Schedule 2 to Schedule 3 to the Advisory Committee on Medicines Scheduling (ACMS) in early 2011. The proposal was submitted by the Advisory Committee on Non-Prescription Medicines (ACNM) as they were currently assessing a product in which the sponsor did not satisfactorily establish the efficacy and safety of the product and that public health concerns raised during the assessment of the product could be addressed by access to a pharmacist. AFT Pharmaceuticals had submitted a product application with the TGA at the time of this item being considered by the delegate and ACMS.
IGF-1 also increases the activity of muscle protein synthesis and the activity of muscle stem cells (also called satellite cells) for repair of damaged muscle. This is probably why intense weight training is one primary stimulus for a natural release of IGF-1 in muscle. As a matter of fact, exercise researchers have found that systemic IGF-1 normally produced in the liver isn’t even required for this type of muscle repair, as other IGF-1 forms produced by your own muscles during and post-exercise allows for adequate muscle tissue repair.
Ipamorelin, like other growth hormone peptides, is used to increase production of your own growth hormone levels. Growth hormone levels are at their peak in our twenties, and then gradually decrease with age. There are a few different peptides including Sermorelin, GHRP2, GHRP6, and Ipamorelin. These peptides are listed in order of how recently they have been developed, with Ipamorelin being the newest and most commonly recommended.
Peptides are defined as a compound of two or more amino acids in which a carboxyl group of one is united with an amino group of another. With the elimination of a water molecule, a peptide bond is formed. To put it more simply, peptides are just small proteins. When the number of amino acids are less than 50, these are peptides. When higher than 50, these are proteins. The peptides are therefore small chains of amino acid which are present in all cells of the body. There are several kinds of peptides: oligopeptides, polymers, proteins, neuropeptides and peptide hormones. These are synthesized naturally by the body. Peptides will therefore be used primarily to make a more abundant amount of hormones in the body. The latter will then produce new hormones such as Testosterone or corticosteroids. It is these two hormones that are considered anabolic or indirect anti-inflammatory.
However, it cannot be legally imported without a special permit under the strict Special Access Scheme, which requires a doctor to apply to the TGA for permission to treat a particular patient with the drug, including describing the specific clinical need. ''There have been no applications under the SAS for AOD-9604,'' the TGA spokeswoman confirmed on Thursday.
The evidence so far suggests that there may be some effect on cartilage and bone densities, and it is correlated with weight loss. I understand that there is no evidence to suggest that it stimulates the release of IGF-1, which is the mechanism via which growth hormone gets most of its purported performance enhancing effects (i.e. muscle bulk). Whilst this is a decent list of things to test if one is considering AOD9604 as simply a variant of growth hormone, it is by no means exhaustive of all the mechanisms via which a drug can enhance athletic performance. The evidence thus far suggests that AOD9604 could be performance enhancing, but there is nothing I would hang my hat on. That is why I maintain that Dank is more sorcerer than scientist.
In order to demonstrate safety, several human studies were performed with AOD9604 (supplementary data): 1). METAOD001: A Phase I (double-blind, placebo-controlled, dose escalation) safety study with doses (ranging from 25 to 400 µg/kg AOD9604) administered intravenously to 15 healthy adult male volunteers presenting with a BMI between 24 and 30 kg/m2. A single dose of recombinant hGH (0.12 international units/kg) was administered intravenously as positive control. 2). METAOD002: A Phase IIa (double-blind, placebo-controlled 4 × 4 Latin Square design) safety study with single doses (25, 50 and 100 µg/kg AOD9604) administered intravenously to 23 healthy clinically obese males presenting with a BMI ≥ 35 kg/m2. 3). METAOD003: A Phase IIa (double-blind, placebo-controlled 4 × 4 Latin Square design) safety study with single doses (9, 27 and 54 mg AOD9604) administered orally (capsules) to 17 healthy, clinically obese males presenting with a BMI ≥ 35 kg/m2. 4). METAOD004: A Phase IIa (double-blind, placebo-controlled, dose escalation) safety study with multiple daily doses (9, 27 or 54 mg AOD9604) administered orally (capsules) for seven days in 36 healthy clinically obese males presenting with a BMI ≥ 30 kg/m2. 5). METAOD005: A Phase IIb (randomized, double-blind, placebo-controlled) study to assess the efficacy (reduction in body weight), safety and tolerability of 12 weeks treatment with daily doses (1, 5, 10, 20 or 30 mg AOD9604) administered orally (capsules) in 300 healthy, clinically obese males, and females of non-child bearing potential, with a BMI ≥ 35 kg/m2. 6). METAOD006: A Phase IIb, randomized, double-blind, placebo-controlled study to assess the efficacy (reduction in body weight), safety and tolerability of 24 weeks treatment with different doses of AOD9604 tablets (0.25 mg, 0.5 mg, 1 mg, or placebo) in 502 obese adults.

Similar to GHRP 2, this peptide is a more potent releaser of growth hormone, also acting on the ghrelin receptors of the anterior pituitary. Also like GHRP 2, GHRP 6 leads to increased growth hormone production, increased lead body mass, and decreased adiposity. Due to the peptide’s ghrelin-like properties, administration can lead to increased appetite.


Often when something is too good to be true, it usually is. The reality is peptides are not a magic potion that substitutes good nutrition, exercise and lifestyle choices. Fundamentally, peptides enhance the body’s own natural processes to produce their various effects, and many of these protein chains are already produced in the body to a certain degree. Often referred to as “the fountain of youth”, certain peptides have shown to reverse the decline in metabolic processes and repair associated with aging, restoring the body back into a more regenerative, youthful state by stimulating release of the body’s own natural human growth hormone (hGH).
Note: If you are a person concerned about loss of muscle mass, you can consume a small amount of protein every 2-3 hours (amino acid tablets such as EAA and BCAA are good for this purpose and can be purchased from any health food shop or ordered online). However there is little reason to be concerned about muscle loss because when fat is available for energy, such as following HGH Frag 176-191 injections, protein and therefore muscle mass are spared.
Peptide supplementation is fast becoming Australia’s solution to a variety of health, fitness, and age-related concerns. Peptides have been around long before the recent media brought it to our attention through use in elite sport. The simple science of amino acids linked together, via peptide bonds, brings to life this now common word—peptides. Some of the benefits that peptides can assist you with during your journey to health and wellbeing include:
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