Thymosin beta-4 (TB-4): A naturally occurring protein found in blood platelets, TB-4 plays a role in the repair and regeneration of injured tissues in the human body. It was first detected in the thymus, a gland that produces white blood cells. While it’s recently been used to treat horses and implicated in horse doping, it’s also found its way into bodybuilding circles. While there is no published evidence that TB-4 produces any benefit to athletes, it was added to the WADA banned substances list in 2011.

In the 80 years, scientists have searched different peptides and more particularly GHRH to discern what part was necessary to stimulate the pituitary response. Then in testing Sermorelin as a tool for the process of anti-agingthey found that it was the famous 1-29 chain that was responsible for stimulating the endocrine gland in question. Similarly, many studies have shown that this peptide was similar to GHRH and very well tolerated by the body.
CJC 1295 is a fast working growth hormone releasing hormones devised to reduce the effects of ageing. It works by stimulating the body’s natural growth hormone production and the release of IGF-1. The advantages of the CJC peptide is it helps increases bone density and collagen, as well as boosting the immune system. It will also produce new muscle cells which will be leaner and increases weight loss. The CJC 1295 results are part of years of scientific studies. It primarily increases the production of proteins, which leads to stable bodily functions related to the glands in the body or the endocrine system.

People who are serious about losing weight or improving physical performance may choose to use some of the controversial peptides. They are generally sold for research purposes, but many injectable forms of peptides have been used by athletes to increase the production of their body’s HGH to achieve increased lean body mass, decreased body fat, and improved recovery time after workouts. Peptides used for these purposes include:
Endurobol (GW501516): Classified under a group of drugs called peroxisome proliferator-activated receptor (PPAR) agonists, Endurobol’s potential abuse in athletes is based on animal studies that showed it could improve endurance, increase fat metabolism, improve glucose uptake in skeletal muscle tissue, and increase in muscle gene expression. At the moment, there is insufficient evidence for these sport performance outcomes in humans. Human side-effects are currently also unknown. Endurobol is prohibited both in and out of competition under WADA’s Prohibited List.
Conclusions: Subcutaneous administration of CJC 1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 ug/ kg. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC 1295 as a therapeutic agent.
Django Nathan, a medical doctor with a degree in molecular biology and genetics, takes peptides because of his busy lifestyle: "Quite a few doctors I know are using them because they have so many beneficial effects and so few side effects. We're not elite athletes – we live rushed lives that can involve 70 hour weeks so staying fit and getting good sleep is essential – and peptides aid that."
IGF-1 is the only natural hormone that can stimulate lean muscle mass gains and help the body choose to burn stored fat over simple glucose for fuel, meaning, you will burn off more fat. Studies demonstrate that only colostrum supplements containing lactoferrin can produce lean muscle gains that complement IGF-1 supplementation. That’s because it is actually the lactoferrin in some brands of colostrum that work to increase muscle mass and to burn adipose tissue. In fact, in a recent 2013 study, participants who supplemented with lactoferrin over a period of eight weeks experienced increased weight loss, reduced visceral and subcutaneous fat, reduced waist circumference, and reduced hip circumference.
Results: After a single injection of CJC 1295, there were dose dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 d or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9–11 d. The estimated half-life of CJC 1295 was 5.8–8.1 d. After multiple CJC 1295 doses, mean IGF-I levels remained above baseline for up to 28 d. No serious adverse reactions were reported.
Within all the clinical trials the subjects received either the active treatment AOD9604 Tyr-hGH177-191(Metabolic Pharmaceuticals Ltd.; amino acid sequence: YLRIVQCRSVEGSCGF; CAS Registry Number: 38624-39-7; INCI Name: 27701 sh-Oligopeptide-74) or placebo (vehicle of mix of excipients). In addition, in study METAOD001 individual subjects were treated with rhHG (0.12 IU/kg; supplied by Unichem in the form of somatropin (Saizen® - Serono)) as a positive control. The administered doses of the study product ranged from 25 µg up to 400 µg per kg bodyweight for the injectable product (i.v. administration in study METAOD001 and METAOD002) and from 0.25 mg/day to 54 mg/day for the orally administered capsules/tablets (capsules METAOD003 - METAOD005; tablets: METAOD006).
I have questions about combined therapy of CJC 1295 and Ipamorelin at the same time on a daily basis for both. The compounding pharmacies do not clearly state whether the CJC is with or without DAC. If it is the CJC with DAC, which sustains elevated GH and IGF-1 for several days, would taking it nightly in conjunction with the Ipramorelin, that is suggested to be taken TID but is being recommended only once at night, be over-stimulatory? If the CJC is without DAC, why take two pepetides simultaneously ,that have similar effects? I am just not clear why taking a daily dose of CJC with Ipamorelin as a single dose is better than taking the CJC with DAC twice per week alone or take the CJC with DAC for a while then switch to the Ipamorelin for a while?
Press coverage and word of mouth has generated quite a bit of hype around AOD9604. Despite its popularity on the black market, there is no research into the safety and effect of injecting this peptide at high doses. Intriguingly, it is not currently in Calzada's interest to fight the black market production of AOD9604, even though it is a patented product. Calzada lack the funds to legitimately boost the reputation of this peptide through clinical trials, and there is a strong chance these would once again prove that AOD9604 has no effect. The good reputation this peptide currently enjoys is likely to provide strong leverage to its marketing as a food supplement in the United States.
These findings suggest that the acute effects of AOD9604 are quite different from the chronic effects. Enhancedβ 3-AR expression appears to play a major role in the chronic effectiveness of the compound in terms of fat metabolism and weight loss. The acute effects observed in this study confirm that the β3-AR is not the sole mediator of this action. The increase in β3-AR expression in response to hGH and AOD9604 would permit enhanced lipolytic sensitivity. Identification of the components of the intracellular pathway(s) and effector(s) activated by AOD9604 are currently being investigated. The results presented in this paper suggest that the effectiveness of AOD9604 and hGH may partly rely on their ability to increase levels of β3-AR RNA expression in models of obesity in which the numbers of the lipolytic receptor are low. These unique properties may give AOD9604 an advantage over other lipolytic agonists such as adrenergic agents and hGH, which exhibit undesirable side effects when administered chronically (22).
IGF-1 is so named because of its close resemblance to insulin. Because IGF-1 is so similar to insulin, it interacts with insulin receptors on the surface of your cells, produces some of the same effects as insulin and even magnifies the effect of insulin. For example, one primary effect of both excess insulin and excess IGF-1 is hypoglycemia (low blood glucose). When you workout for a long time (longer than about one hour) your liver increases its release of IGF-binding protein (IGFBP-3) to prevent the onset of hypoglycemia that would otherwise happen as a result of the increased release of IGF-1 that occurs during training.

The evidence so far suggests that there may be some effect on cartilage and bone densities, and it is correlated with weight loss. I understand that there is no evidence to suggest that it stimulates the release of IGF-1, which is the mechanism via which growth hormone gets most of its purported performance enhancing effects (i.e. muscle bulk). Whilst this is a decent list of things to test if one is considering AOD9604 as simply a variant of growth hormone, it is by no means exhaustive of all the mechanisms via which a drug can enhance athletic performance. The evidence thus far suggests that AOD9604 could be performance enhancing, but there is nothing I would hang my hat on. That is why I maintain that Dank is more sorcerer than scientist.

CJC-1295 10mg (Up to 10 Weeks): Started Wednesday 21 st September 2016 weight 122 kilo. Belly measurement 122cm Thursday 22nd September Weight @ 3pm 118.5 kilo Belly Measurement 117cm Morning and night 3 pumps Stacking with CJC1295 injectable. Lots of energy feel great aches and pains starting to subside.I will be doing a few more courses in the near future. THANKS Awesome products. Shane Ridley

Five patients in the study reported a serious AE; three in the AOD9604 20 mg group (basal cell carcinoma, moderate lipoma and squamous cell carcinoma), one in the 5 mg group (breast cancer) and one in the 10 mg group (malignant melanoma). According to the investigator, none of the SAEs reported were considered to be possibly, probably or definitely related to study medication (see discussion).
Follow the same routine as shown above for "intermediate" persons. However, as soon as possible after your weight training you should also inject 200mcg of PEG-MGF (IGF-1e) and/or 50mcg of IGF-1 LR3 preferably into a muscle (although due to the long half-life of both products, sub-q injections are also acceptable). If injecting intramuscularly, you should make sure that the muscle you are injecting into is not covered by a thick layer of fat. Usually due to the length of insulin syringe needles, injections are therefore limited to the biceps for most persons.
In this study, AOD9604 was given in a dose of 0.25 mg that is comparable to the dose used in a previous report [8] on GH in promoting recovery to normal walking and in joint repair in the rabbit collagenase model of osteoarthritis. AOD9604 is a fragment of GH; therefore the dose of AOD9604 used was the molar equivalent of the active GH dose that the previous study [8] used. Human GH was given as 3 mg in 0.6 ml intra-articular injection volume. On a molar basis, 3 mg of GH equates to 0.25 mg of AOD9604. In addition, published data [10] suggest that the volume of synovial fluid in an arthritic rabbit is approximately 0.7 ml. Combined with the injection volume, this gives a total volume of 1.3 ml and therefore an initial concentration of AOD9604 of 0.19 mg/ml. In a previous study [11] of GH in the beagle after intra-articular injection, researchers injected 1.5 mg of GH in aqueous solution in 0.15 ml volume. The aqueous formulation gave an initial concentration of approximately 200–300 ug/mL in the synovial fluid. On a molar equivalent basis this equates to 0.11 mg/mL of AOD9604, which is close to the value used in this study.
Remember the GHRP you select is used for a few reasons. One is to prompt the release of the increase pulse in GH you have initiated with the GHRH you have selected to use. This is by inhibition of Somatostatin. So you are actually selecting the timing of the release of your natural production of  still physiologic amount of GH.  Another reason is to actually contribute a little more to the amplitude of you GH pulse.

In vitro and in vivo investigations revealed a specific region within the hormone molecule that is responsible for the molecular events associated with lipid metabolism [18, 24, 25]. AOD9604 is a peptide fragment of the C-terminus or lipolytic domain of hGH (hGH177-191), with an additional tyrosine residue at the N-terminal end for stabilization. In vitro and in vivo experiments have shown similar effects of AOD9604 and hGH on lipid metabolism when chronically applied to mice [20, 21]. Interestingly, AOD9604 mimics the effect of hGH on lipid metabolism, without having growth promoting or pro-diabetic effects. The safety and tolerability of AOD9604 has been studied in the human clinical trials described in this paper.
I'm using 100mcg 6am-12pm-6pm(3xday) HGH Fragment 176-191 and the last shot around 6pm taking 100mcg of GHRP-6 from SouthernResearchCo, I gotta brag on their quality and value there's no others on the same level (IMO)! I dropped 10-15lbs as soon as I started too! NO catabolic or any adverse effects. Well, I did get head aches and super shits when I first began but by wk2 I notice nothing and feel so great! My tummy looks so much better too, my wifes all jealous as hell n gets mad saying she wont compliment it cuz I use drugs to attain leanness lol Fk it
We identified 34 patients who met eligibility criteria based on the chart review. Two subjects were excluded because they were found to have diabetes requiring insulin therapy, 1 was excluded because of hypothyroidism, and 13 were excluded because they did not undergo gastric bypass surgery or did not wish to participate. A final study sample of 18 individuals (15 women) was enrolled into the protocol. We had 3 individuals who did not complete the 6‐month follow‐up visit; the sample that completed both visits consisted of 15 individuals (12 women). No subjects were excluded because of peri‐operative complications. Table 1 displays the characteristics of the study sample at baseline and 6 months after surgery. From baseline to 6 months after surgery, subjects had a mean decrease of 27% in body mass index (P<0.0001). There were significant reductions in mean arterial blood pressure (P=0.004) and heart rate (P<0.001) after surgery. Only 2 out of 18 subjects were on any class of anti‐hypertensive medications at the pre‐op visit before gastric bypass surgery. At the 6‐month visit, anti‐hypertensive medication was discontinued for one of these subjects, and continued at the same dose for the other subject. The mean±SD volume of saline infusion pre‐bypass was 2.6±0.4 L and post‐bypass was 2.3±0.3 L.
These results also demonstrate that, unlike hGH, AOD9604 has no negative effect on carbohydrate metabolism. This was previously demonstrated in mice. Chronic administration of hGH to ob/ob mice depressed glucose oxidation and increase plasma glucose levels. AOD9604 had no such effects, no changes in circulating plasma glucose in either lean nor obese ob/ob mice have been observed [20]. AOD9604 did not cause hyperglycemia or affect insulin sensitivity in rats and mice [18, 20].
Strengths of our study include the serial physiologic assessments before and after bariatric surgery. The gastric bypass procedure ensured a large degree of weight loss (≈27% mean change in BMI), while the administration of normal saline provided an acute stimulus for eliciting acute natriuretic peptide responses. Thus, we were able to compare the relative effects of weight loss and saline infusion, with each individual serving as his or her own control. This study design minimizes confounding from sources of natriuretic peptide variation that might correlate with BMI. We performed the post‐surgical assessment 6 months after surgery to ensure that acute hemodynamic changes from surgery had resolved and patients had attained most of their expected weight loss. Mitral annular early diastolic (e′) velocity at the lateral annulus has been accepted as an index of diastolic function24, 25 and we had significant improvement in e′ suggesting improvement in myocardial relaxation. Our echocardiographic findings are in accordance with the recently published meta‐analysis demonstrating benefits of bariatric surgery on diastolic function.26
AOD9604 is a peptide (a chain of amino acids) which was developed and patented by a company called Metabolic Pharmaceuticals in Australia in the late 1990s. AOD stands for "Anti Obesity Drug". This peptide has an amino acid sequence that mimics the lipolytic region of human growth hormone (the region of this hormone thought to be responsible for burning fat) and it has been promoted variously as a weight loss supplement, as an aid to muscle and cartilage repair, and a treatment for osteoarthritis by its manufacturers. It is also known as lipotropin and Tyr-hGH fragment, and is generally available these days as a transdermal cream or an injectable.
The effect of AOD9604 and hGH on β3-ARs in adipose tissue is believed to be a direct action of these compounds and not an effect secondary to the fat metabolism, given that both AOD9604 and hGH can influence β3-AR expression and function in a nonadipocyte human cell line (11). Hence, the β3-AR appears to be necessary for the chronic effectiveness of AOD9604 on lipolysis in BAT.
The rabbits were clinically observed daily at 14:00. The rabbits were placed on a 2-m2 ground area, and gait was individually assessed by direct observation for 20 minutes. The knee and ankle of the intact rabbit limb showed typical flexion and extension cycle during hopping. Lameness was defined as the inability to bear weight and the loss of typical flexion and extension cycle of the affected limb during hopping compared with that of the unaffected limb. The severity of lameness was not quantified. The time taken to return to normal ambulation without lameness of the affected limb was recorded for each group. The lameness period was checked by three independent physiatrists who did not have knowledge of the experimental groups.
From the standpoint of protein synthesis and muscle repair, IGF-1 injections have also been shown to enhance the anticatabolic effects of insulin and to increase the protein synthesis normally induced by growth hormone. This is because, like insulin, IGF-1 encourages amino acid uptake into muscle cells, stimulates peripheral tissue uptake of glucose (which lowers blood glucose levels), and suppresses liver glucose production. That last fact is important and is actually why IGF-1 is even being considered as a diabetes-prevention drug. Insulin resistance can cause the liver to produce excess glucose, which then causes even more insulin insensitivity and can eventually result in type II diabetes, and IGF-1 can decrease the need for this type excessive insulin release.
IGF-1 is so named because of its close resemblance to insulin. Because IGF-1 is so similar to insulin, it interacts with insulin receptors on the surface of your cells, produces some of the same effects as insulin and even magnifies the effect of insulin. For example, one primary effect of both excess insulin and excess IGF-1 is hypoglycemia (low blood glucose). When you workout for a long time (longer than about one hour) your liver increases its release of IGF-binding protein (IGFBP-3) to prevent the onset of hypoglycemia that would otherwise happen as a result of the increased release of IGF-1 that occurs during training.

also using a dose of 400mcg for the IPAM is really a waste of your peptides as anything above saturation dose will give diminished returns, saturation dose(1mcg per kg) is a dose that will give maximum return, if you double the saturation dose then you will not get double the GH pulse in fact no where near that, then the more you use the less added benefit you will get.
In ob/ob mice, both AOD9604 and hGH reduced both white and brown adipose tissue mass and increased β3-AR RNA expression. This suggested that an elevation inβ 3-AR RNA expression is associated with increased fat metabolism and a reduction in the fat tissue mass in the ob/ob mouse model. Obese mice have lower levels ofβ 3-AR expression in their adipose tissues than lean mice, shown in this study and others (14). The ability of AOD9604 and hGH to increase the level ofβ 3-AR RNA expression in obese mice to a level that is comparable to those in lean mice is an exciting finding. However, it must also be considered that both hGH and AOD9604 may influence the expression of other members of the adrenergic pathway, such as the β1-ARs, hormonesensitive lipase, and signaling proteins, which are all expressed in adipose tissue and associated with lipolysis. The importance of the change inβ 3-AR expression with AOD9604 and hGH in humans is not established and will depend on the use of potent and selectiveβ 3-AR agonists that are active at the human receptor.
Natriuretic peptide measurements were tested for normality and were logarithmically transformed for analysis. We used paired t tests to examine the change in BMI, blood pressure, and natriuretic peptides before and after surgery. Mixed effect models using all non‐missing data from 18 study subjects were used to assess the effects of surgery and intravenous saline and their interaction on plasma Nt‐proANP, Nt‐proBNP, and mature ANP and BNP levels, as well as echocardiographic measures. To account for repeated measures for each subject, a spatial power structure for ANP. Nt‐proANP, BNP, and Nt‐proBNP, and a completely general (unstructured) covariance matrix for echocardiographic outcomes were used. None of the interactions terms were significant and P values reported are based on models without interaction. A secondary analysis after covariate adjustment for age, sex, and blood pressure was also performed. All analyses were conducted using SAS (Cary, NC). A two‐sided P<0.05 was considered statistically significant for the primary outcome.

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