The Vital Proteins Collagen Peptides that I used claimed that it could dissolve in hot or cold liquids. However, I found it dissolved much easier when I poured some into hot tea or blended it into a smoothie. For the majority of the two weeks, I put my collagen peptides in my morning iced coffee. Instead of dissolving nicely, however, it ended up clumping into gelatinous pieces throughout my coffee. Although the peptides eventually dissolved with frequent stirring, I sometimes ended up slurping up chunks of the peptides.
The second long-term study (METAOD006) was a randomized, double-blind, placebo-controlled, multi-center, parallel group study conducted at 16 Australian hospitals and medical centres. In that study 534 were enrolled but of those 502 clinically obese subjects (BMI ≥ 30 kg/m2 and ≤ 45 kg/m2; Median BMI: 36.3 kg/m2, range: 30 to 45.2 kg/m2; 44% males and 56% females) were randomized to receive a daily dose of 0.25, 0.5 or 1mg AOD9604 or placebo for 24 weeks. Prior to this treatment period all subjects underwent a 4-week single-blind placebo run-in period. After cessation of the treatment a 4-week follow-up phase was performed.
We identified 34 patients who met eligibility criteria based on the chart review. Two subjects were excluded because they were found to have diabetes requiring insulin therapy, 1 was excluded because of hypothyroidism, and 13 were excluded because they did not undergo gastric bypass surgery or did not wish to participate. A final study sample of 18 individuals (15 women) was enrolled into the protocol. We had 3 individuals who did not complete the 6‐month follow‐up visit; the sample that completed both visits consisted of 15 individuals (12 women). No subjects were excluded because of peri‐operative complications. Table 1 displays the characteristics of the study sample at baseline and 6 months after surgery. From baseline to 6 months after surgery, subjects had a mean decrease of 27% in body mass index (P<0.0001). There were significant reductions in mean arterial blood pressure (P=0.004) and heart rate (P<0.001) after surgery. Only 2 out of 18 subjects were on any class of anti‐hypertensive medications at the pre‐op visit before gastric bypass surgery. At the 6‐month visit, anti‐hypertensive medication was discontinued for one of these subjects, and continued at the same dose for the other subject. The mean±SD volume of saline infusion pre‐bypass was 2.6±0.4 L and post‐bypass was 2.3±0.3 L.
The scheduling of paracetamol and caffeine when combined in a compound analgesic as the only two active ingredients was amended from Schedule 4 to Schedule 2 by the NDPSC at its 50th Meeting in June 2007. Evidence reviewed by the Committee at that time conclusively demonstrated that the key ingredient in terms of analgesic overuse and nephropathy was phenacetin and not caffeine. It was agreed that the indications for use, safety profile and potential for misuse met the criteria for a Schedule 2 medicine.
In the first dose-escalating study (METAOD001) 15 healthy male subjects received 3 single dosages of AOD9604 and placebo as single dosages each separated by a 7-day washout period (range 25 to 400 µg/kg bodyweight; single IV infusion doses over 20 minutes). One subject terminated the study due to personal reasons, 14 subjects completed the study. In total twenty-nine AEs were reported by twelve subjects during the study. No SAEs occurred during this study. The most common AEs reported during the study were headache (6 times). The remainder were related to fatigue (4), hypoglycemia unspecified (3), dizziness (3), nasopharyngitis (2), cough (2) and lethargy, tonsillitis, abdominal pain unspecified, application site reaction unspecified, sore throat unspecified, injection site bruising, rhinitis seasonal, anorexia, injection site pain, all with an incidence of 1. None of the AEs were of severe intensity. The majority of AEs were mild in intensity with possible relationship to study treatment, equally distributed between the various concentrations of AOD9604 and placebo treatment. The adverse event profile was similar following administration of all treatments.
AOD9604 is promoted heavily by various manufacturers as a substance that is able to burn fat and assist in the repair of muscle and cartilage. The fact that this product derives from, and claims to mimic the effects of a powerfully anabolic banned substance provides a psychological incentive to many potential users, as does the attention drawn by the AFL "peptides" scandal of early 2013 and the subsequent report by the Australian Crime Commission (1).
Amongst its metabolic effects, hGH can induce inhibition of lipoprotein lipase activity in adipose tissue, stimulating lipolysis in adipocytes, which results in the reduction of fat cell mass [4-7]. Moreover, a correlation has been found between adiposity and the reduced circulating levels of hGH . When applied systemically, hGH reduces body fat mass and influences fat distribution . Therefore, treatment with hGH should theoretically have a positive impact on obesity. However, long term treatment with hGH is associated with various health risks, including glucose intolerance and insulin resistance, diabetes, acromegaly, cancer, edema, and hypertension [10-13].
Many patients use Ipamorelin short term (3-6 months) for fat loss benefits and overall improvements in body composition. Ipamorelin increases fat metabolism, so when age starts to become a factor in a person’s ability to lose weight, this peptide can create a more efficient and sometimes faster process. Patients that are also physically active tend to notice even faster benefits while using Ipamorelin, as it aids recovery from workouts and allows for faster progression and typically more fat loss. Once a patient’s desired weight has been achieved, Ipamorelin use can be discontinued, and weight maintenance can be achieved through diet and lifestyle changes.
The world is talking about peptides’ unique ability to build new muscle cells. The amino acids used in the formation of muscle are allowed to combine due to the action of peptide bonds. Professional athletes and healthcare professionals alike swear by them, and these supplements are known to naturally boost the metabolism, which can increase energy and overall happiness.