Recent advances in the field of regenerative medicine, such as the use of platelet-rich plasma and stem cell injections, are emerging as the preferred options for treating OA. This is in part because patients do not desire only temporary alleviation of symptoms. Rather, patients also seek permanent correction and repair of the underlying biology for regenerating the damaged tissue in order to permanently alleviate their symptoms [4]. The aforementioned treatment options have been used in several areas of medicine for delivering growth factors to optimize healing.
The most potent weight loss peptide is HGH Fragment 176-191 which is the part of the Growth Hormone molecule responsible for fat burning. In HGH Frag Studies, it has been proven to reduce body fat, particularly in the abdominal area. The second most potent fat loss peptide is CJC-1295 DAC since it causes the overall GH level to rise in the body (the opposite of what happens naturally as a person gets older, which is why people tend to put on weight as they age). If your only goal is fat loss, it's often best to avoid the use of GHRP products (GHRP-6, GHRP-2 or Ipamorelin) since they can stimulate hunger and/or raise cortisol, both of which can be counterproductive to fat burning.
After about a week of taking the collagen, I noticed my nails were thicker and stronger and were growing faster. Usually, my nails break and tear off after they grow, but after drinking my collagen, they were growing nicely and faster than normal. In fact, when I got a gel manicure, which is supposed to last up to two weeks, my nails grew out after about eight or nine days, leaving the bottoms of my nail beds exposed. Although it was annoying having to get my nails redone, it wasn’t a bad problem to have!
Diets on point! 6 600 calorie meals totaling 200-300g protein, 50-150g carbs and almost NO fat. I do get a little fat in my diet from flax, trail mix and what not but all my food is natural, whole and as close to organic as I can get.. TONS of raw veggies. NO cardio atm, Ive got some bad injuries and issues developed from my last cycle so I take it pretty easy LOL. Maybe an hour on the bicycle 1-2x/wk.. Tough job tho so at work 8hrs a day working on diesel pile hammers keeps my heart rate pretty high all day
Time line of collagenase, saline, HA and AOD9604 injection. Collagenase (0.25 mg) was injected in right knee twice on day 1 and 4, respectively. Normal saline 0.6 ml (group 1), HA 6 mg (group 2), AOD9604 0.25 mg (group 3), and AOD9604 0.25mg with HA 6 mg (group 4) were injected in the right knee at 4 weeks after the first collagenase injection. All rabbits were euthanized by CO inhalation at 4 weeks after injection of 4 different solutions.
 Please note, as this is a prescription item, one of our doctors will review your profile and approve your order if appropriate. A prescription will only be issued in accordance to the prescribing guidelines, and for use that strictly complies to the doctor’s directions and dosage. This script will be forwarded to our dispensary team, and placed in our secure, internal records.

Human Growth Hormone (hGH) is not only important for growth processes during childhood, but plays a pivotal role in lipid metabolism throughout life. It is well known that hGH is involved in the regulation of lipolysis and lipogenesis. Therefore, hGH was implicated as a good potential candidate for the treatment of obesity. However undesired side effects, such as induction of glucose intolerance and insulin resistance, diabetes, acromegaly, cancer, edema, and hypertension [10-13] rendered therapeutic doses of hGH unsuitable for long-term treatments in humans.
The effect of AOD9604 treatment on IGF-1 levels was of particular interest, since hGH administration is associated with increases in IGF-1 levels. Prolonged increases in IGF-1 may have a variety of undesirable effects, including an increase in cancer risk [22, 23]. In this study the levels of circulating IGF-1 were measured at the baseline visit and at the end of the 12-week treatment period. There was no significant change in the levels of IGF-1 in any of the treatment groups (Table 1).
Twelve WT and 11 β3-KO male mice aged between 12 and 14 wk were used in the chronic administration study. The animals were housed individually in cages under the conditions described above. The animals were divided into three groups: WT [control (saline; n = 3); AOD (250 μg/kg·d; n = 4) and hGH (1 mg/kg·d; n = 5)] and β3-KO [control (saline; n = 3); AOD (250 μg/kg·d; n = 4); and hGH (1 mg/kg·d; n = 4)]. On d 0, all animals were anesthetized with sodium pentobarbitone and a collection of blood (200 μl) was taken in heparinized tubes (Terumo, Somerset, NJ) for glycerol determination. The plasma was isolated by centrifugation and stored at −20 C until required for analysis. For the following 28 d, the animals were given a single ip dose of compound at 0800 h each morning. Their food intake and body weight were recorded every second day and results expressed as a change from d 0. On d 28, the animals were anesthetized with sodium pentobarbitone, blood was collected for plasma glycerol determination, and they were then killed by a lethal injection of sodium pentobarbitone to the heart (35 mg/kg). Their white epididymal and brown subscapular adipose tissues were collected and weighed.
In this study, plasma glycerol was also assayed as a measure of lipolytic rate. As shown in Fig. 5C, both AOD9604 and hGH increased glycerol levels following treatment in the WT mice, indicative of enhanced lipolysis. In the β3-KO mouse, however, no effect was observed with AOD9604. A significant increase in plasma glycerol from controls was observed following hGH treatment, but this was markedly less than that observed in the WT mouse. These data indicate the importance of β3-AR in the lipolytic response to AOD9604 in these animals and the necessity of the receptor for the chronic effectiveness of AOD9604 and hGH on fat reduction.
By increasing our own growth hormone levels (which normally decrease as we age), there is an increase in protein synthesis which subsequently stimulates muscle growth.  It leads to an increase in muscle mass, an increase in fat metabolism (fat loss), and increase in physical strength.  It is also helpful in skin ageing, and effective in reducing wrinkles.
AOD9604: AOD9604 is a synthetic peptide taken orally. The small peptide mimics a section of the growth hormone molecule which increases fat metabolism and decreases the production of fat. AOD9604 is claimed to reduce fat, increase muscle mass and possibly help recover from joint cartilage damage. However, there is currently no published human data to support these claims. AOD9604 is not approved for human use, but is used in sport for weight loss and muscle enhancement and the perception that it helps recover from tissue damage. This drug was highlighted in the Australian Crime Commission report on Organised Crime and Drugs in Sport. No significant adverse effects have been reported yet, but AOD9604 is now prohibited by WADA.
A similar clinical study was conducted in obese subjects (METAOD002). In that double-blind placebo-controlled, 4 sequence, 4 period William’s Latin Square design study 23 subjects participated. The subjects were 19 to 50 years old and had a BMI ≥ 35 kg/m2 (range 36 to 67 kg/m2). Each subject received 4 single doses (25, 50 and 100 µg/kg AOD9604 or placebo; single IV infusion doses over 20 minutes), separated by a 7-day washout period.
Ironically, it only appears that the version of IGF-1 produced in your own muscle has any true anabolic effects. But nonetheless, many folks who’ve used IGF-1 claim to have experienced significant anabolic effects of injections. However, the only evidence for such anabolic effects have been shown in people who are already clinically deficient in IGF-1.
These findings suggest that the acute effects of AOD9604 are quite different from the chronic effects. Enhancedβ 3-AR expression appears to play a major role in the chronic effectiveness of the compound in terms of fat metabolism and weight loss. The acute effects observed in this study confirm that the β3-AR is not the sole mediator of this action. The increase in β3-AR expression in response to hGH and AOD9604 would permit enhanced lipolytic sensitivity. Identification of the components of the intracellular pathway(s) and effector(s) activated by AOD9604 are currently being investigated. The results presented in this paper suggest that the effectiveness of AOD9604 and hGH may partly rely on their ability to increase levels of β3-AR RNA expression in models of obesity in which the numbers of the lipolytic receptor are low. These unique properties may give AOD9604 an advantage over other lipolytic agonists such as adrenergic agents and hGH, which exhibit undesirable side effects when administered chronically (22).
•Avoid eating/drinking anything with calories for three (3) hours either side of your injection. •Try to make all your meals throughout the day high protein, low fat and low carbohydrates (eg. meat/fish with vegetables/salad). •Have as few meals as possible during the day as periods of fasting have been shown in many studies to improve fat loss and also longevity (i.e. eating less will make you live longer).
Athletes will greatly benefit from using Ipamorelin. For example, if you use CJC 1295 along with Ipamorelin, the results are going to be even greater. HGH increase will result in greater muscle mass levels, less time for muscle mass to develop, and increased levels of lean muscle tissue. The more peptides your body produces, the greater your lean muscle mass is going to be. And, over time, with gradual increases in HGH, you are going to realize a leaner, more muscular definition to your body.

Just as you could eat more calories than you think if you aren’t keeping track, you might miss some positive results of your efforts if you aren’t tracking your progress. Weigh yourself weekly. Take body measurements of your waist, legs, chest, and arms every other week. Measure your body fat percentage. Take photos of yourself once a month. Sometimes the scale won’t show results from week to week, but if you have all of the other methods of tracking in place, you’ll be able to see your efforts are being rewarded.
Transparent Labs has gone back to the basics their PhysiqueSeries Fat Burner. This thermogenic weight-loss supplement focuses on the 3 keys of fat loss: increasing metabolism, preventing hunger cravings, and improving overall energy and pleasure from fat loss. Ingredients like ForsLean, green tea, and synephrine deliver clinically-proven ingredients to help you reach your goals. Read More

Between 2001 and 2006 six human clinical trials with the hexadecapeptide AOD9604 have been performed, 893 healthy, in all but one study, clinically obese adults participated in these studies and are the basis of this safety evaluation. The details of the individual studies are listed in supplementary data. The first 3 studies were dose-escalating studies investigating the acute effects of various dosages and two application routes (i.v. and oral) in healthy or obese male subjects. These single dose studies were followed by a 7-day multiple dose study (METAOD004) as well as two long-term clinical trials (METAOD005 and METAOD006) where the safety and tolerability of chronic oral treatment with AOD9604 was investigated.
I can't believe we as Aussies are the 1st to point the finger of other countries on drug cheats, as soon as its in our own backyard and one of our afl footy teams, we seem to downplay the seriousness of drugs in sport, its crazy, and to think they didnt know what was being injected, doh. my favorite is the Shane Warne Diuretics that his mum gave him, lol, 12 month ban, Essendon minimum 2 year ban.....has to be.
The prescription form of IGF-1 most often injected is “mecasermin”, which goes by the trade name Increlex. Manufactured using recombinant DNA technology, mecasermin is clinically used to treat IGF-1 deficiency and stunted growth. It is also prescribed to patients who have developed antibody resistance to normal growth hormone therapy. Increlex is actually identical to natural IGF-1, meaning that it has the identical 70 amino acid sequence of IGF-1 that the body produces. In other words, it’s not some kind of growth hormone “precursor”. It’s just straight up IGF-1.
Even, if you are not a fitness enthusiast, you can benefit from using the CJC 1295 Ipamorelin blend. Australia is one of the countries using them to deal with other conditions, which can affect our everyday life. There is an abundance of anti-aging clinics across the Australia that follows strict legal guidelines to sell peptides. Based in Sydney Peptides Clinics, has a good selection of peptides, to help with many conditions that occur with age, from hair loss, depression, fat loss, low libido and tanning.
In lean animals, neither AOD9604 nor hGH had any effect on epididymal white adipose tissue mass or expression ofβ 3-AR RNA, indicating that in lean animals, this fat tissue is not a major target for these drugs in this study. In contrast, the mass of BAT in lean animals was reduced by both hGH and AOD9604, and β3-AR RNA expression was increased by both these compounds. This could possibly suggest that the increased expression of β3-ARs in brown adipocytes sensitizes catecholamines to dissipate heat.

In the 80 years, scientists have searched different peptides and more particularly GHRH to discern what part was necessary to stimulate the pituitary response. Then in testing Sermorelin as a tool for the process of anti-agingthey found that it was the famous 1-29 chain that was responsible for stimulating the endocrine gland in question. Similarly, many studies have shown that this peptide was similar to GHRH and very well tolerated by the body.
An Australian-owned obesity drug, developed by Melbourne-based biotechnology company Metabolic Pharmaceuticals Limited, is set to enter final human trials next year after successfully completing a Phase 2b human trial which proved that the drug induces weight loss and is very well tolerated with no evidence of the side effects commonly experienced with existing obesity drugs.
The knee joints were dissected after euthanasia. The medial and lateral condyles of the femur and tibia were examined for gross morphological changes. The degree of cartilage degeneration on the lateral part of the femoral condyle was assessed using the scoring system devised by Yoshimi et al. [12]. This area was assessed because the intra-articular collagenase injections had caused most damage at this area [13]. Normal cartilage was scored as 0, softened cartilage as 1, fibrillated cartilage as 2, eroded cartilage as 3, ulcerated cartilage as 4, and loss of cartilage as 5.

Plasma Nt‐proANP levels were measured by ELISA (proANP 1‐98; Biomedica Medizinprodukte GmbH & Co KG, Austria). Plasma Nt‐proBNP levels were measured using an electrochemiluminescence immunoassay (Elecsys proBNP; Roche, Indianapolis, IN). Mature ANP was measured using an in‐house immunoassay at the Mayo Clinic (Rochester, MN; J. Burnett). Mature BNP was measured by immunoassay (Siemens, New York, NY). Intra‐assay coefficients of variation were <10% for all assays.

Growth Hormone (GH) exhibits its muscle building effects mainly after its conversion to IGF-1 (Insulin-Like-Growth Factor). This makes IGF-1 an ideal choice of peptides for muscle building, especially since the IGF-1 LR3 version has an extended half-life which allows it to remain active in the muscles for many hours to complete its muscle building stimulatory effects. Likewise, if injected after a workout, the IGF-1 variant Mechano Growth Factor (also known as MGF or IGF-1e) is known to multiply muscle cells and contribute to muscle development. Furthermore, since IGF-1 is a by-product of GH, any peptide which increases levels of GH in the body such as a GHRP product or CJC-1295 product will obviously lead to increased lean muscle mass.
In the 80 years, scientists have searched different peptides and more particularly GHRH to discern what part was necessary to stimulate the pituitary response. Then in testing Sermorelin as a tool for the process of anti-agingthey found that it was the famous 1-29 chain that was responsible for stimulating the endocrine gland in question. Similarly, many studies have shown that this peptide was similar to GHRH and very well tolerated by the body.

A total number of 207 AEs were reported by 36/36 subjects. All but one was of mild to moderate intensity (placebo-treated subject, soft tissue injury to left shoulder, unrelated to study treatment). No SAE occurred during the 7-day treatment and the 7-day follow-up time. The rate as well as the AE profile was comparable in the 9 mg, 27 mg AOD9604 and the placebo group. There was no observable trend between treatment groups with respect to the incidence of certain AEs, however subjects who received 54 mg AOD9604 experienced a greater number of headaches, diarrhea and flatulence.
Cartilage loss in OA is caused by proteoglycan depletion and chondrocyte death that in turn are caused by imbalances between catabolic and anabolic activities within the joint [5]. Growth hormone (GH) has been shown to correct this imbalance [6]. Although the exact mechanism underlying the effects of intra-articular GH injection is not known, GH in the synovial fluid probably enhances proliferation, matrix synthesis, and differentiation of bone and cartilage cells in vitro [7]. Studies have found that GH accelerates healing in animal models of OA [8,9]. However, intra-articular GH injections in humans are known to have detrimental pro-tumor and pro-diabetic effects. These negative effects are caused by the secondarily produced insulin-like growth factor-1 (IGF-1) [10].
AOD9604 and hGH appear to act in a similar manner to induce their effects on body weight regulation and adipose tissue mass in vivo. However, in vitro studies have demonstrated a number of differences suggesting that the two compounds operate via unique signaling pathways to control the regulation of theβ 3-AR. These studies suggested that AOD9604 had no interaction with the β3-AR or hGH receptors (11).
I can't believe we as Aussies are the 1st to point the finger of other countries on drug cheats, as soon as its in our own backyard and one of our afl footy teams, we seem to downplay the seriousness of drugs in sport, its crazy, and to think they didnt know what was being injected, doh. my favorite is the Shane Warne Diuretics that his mum gave him, lol, 12 month ban, Essendon minimum 2 year ban.....has to be.

Results: AOD 9604 had no effect on serum IGF-1 levels, which confirms the hypothesis that AOD 9604 does not act via IGF-1. Results of oral glucose tolerance test demonstrated that, in contrast with hGH, AOD 9604 has no negative effect on carbohydrate metabolism. There were no anti-AOD 9604 antibodies detected in any of the patients selected for antibody assay. In none of the studies did a withdrawal or serious adverse event occur related to intake of AOD 9604.

Several epidemiologic studies have reported lower circulating natriuretic peptide concentrations in obese individuals.12, 14 However, these studies have been observational and confined to a single time point of measurement of natriuretic peptides. To our knowledge, only one previous study has examined the association of obesity with salt‐induced natriuretic peptide concentrations. Licata and colleagues found reduced, salt‐loaded plasma ANP concentrations in 9 obese individuals compared with 10 lean controls.21 They did not examine the influence of weight loss on the natriuretic peptide system. Thus, the present study is the first to provide serial, physiologic data from the same individuals over time.

Figure 1. A, Concentrations of plasma mature ANP levels at baseline and at 40, 80, 120, and 180 minutes after the start of saline infusion. Solid line with squares represents pre‐bypass surgery subjects and dotted line with triangles represents post‐bypass surgery subjects. B, Concentrations of plasma Nt‐proANP levels at baseline and at 40, 80, 120, and 180 minutes after the start of saline infusion. Solid line with squares represents pre‐bypass surgery subjects and dotted line with triangles represents post‐bypass surgery subjects. ANP indicates atrial natriuretic peptide; Nt‐proANP, N‐terminal pro‐ANP.

CJC-1295 is basically a peptide hormone that acts similar to growth hormone releasing hormones (GHRH). Invented by a Canadian biotechnology company called ConjuChem, it is beneficial to athletes because it can bioconjugate with circulating albumin and increase the time it can be used for medical purposes. It achieves this by preventing degradation of its amino acids. With a single dose, it can remain in the body for quite a few days and can cause the growth hormone to be released many times per day. This reduces the frequency of injections needed.
Aging often comes with many undesirable effects on our bodies including increased fat, decreased muscle muscle mass and low energy.  Some of these issues can be caused by adult growth hormone deficiency.  Peptide therapies provide a healthy option to reinvigorate the natural release of growth hormone in the body and reverse the negative effects of aging.
But for maintenance of adequate and natural IGF-1 and growth hormone, and to achieve that sweet spot of not becoming to pro-growth while also not becoming a weak, muscle-less noodle, that sweet spot of producing adequate insulin without producing too much, and that sweet spot of increasing cellular repair without letting cellular division get “out of control”, I have indeed been implementing three specific strategies: my IGF-1 “trilogy”.

The scheduling of paracetamol and caffeine when combined in a compound analgesic as the only two active ingredients was amended from Schedule 4 to Schedule 2 by the NDPSC at its 50th Meeting in June 2007. Evidence reviewed by the Committee at that time conclusively demonstrated that the key ingredient in terms of analgesic overuse and nephropathy was phenacetin and not caffeine. It was agreed that the indications for use, safety profile and potential for misuse met the criteria for a Schedule 2 medicine.
Despite the controversies, some scientists continued with additional studies and again proved IGF-1 to actually prolong life…at least in worms.  Then, in 2001, scientists discovered that the use of IGF-1 resulted in a proliferation of cancer cells, especially throughout the breast and colon, and a 2012 study found that both too much or too little IGF-1 could contribute to dying from cancer; implying that IGF-1 actually helped patients with terminal cancer live longer.
Buy Peptides online from Australia’s most respected supplier of clinical grade peptides. Peptides Online produces only the highest quality peptide products. We are fully licensed and registered with our offices located in Australia. Specializing in the production of medically prescribed, pharmaceutical grade peptides, Peptide Online guarantees optimal purity and potency of their peptide supplements.