Human Growth Hormone (hGH) is not only important for growth processes during childhood, but plays a pivotal role in lipid metabolism throughout life. It is well known that hGH is involved in the regulation of lipolysis and lipogenesis. Therefore, hGH was implicated as a good potential candidate for the treatment of obesity. However undesired side effects, such as induction of glucose intolerance and insulin resistance, diabetes, acromegaly, cancer, edema, and hypertension [10-13] rendered therapeutic doses of hGH unsuitable for long-term treatments in humans.
As it is not yet approved for use in this country (or any other), it should always have been considered banned under the S0 category, which states that any pharmacological substance that is not addressed by any of the subsequent sections of the Prohibited List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited.
In the first dose-escalating study (METAOD001) 15 healthy male subjects received 3 single dosages of AOD9604 and placebo as single dosages each separated by a 7-day washout period (range 25 to 400 µg/kg bodyweight; single IV infusion doses over 20 minutes). One subject terminated the study due to personal reasons, 14 subjects completed the study. In total twenty-nine AEs were reported by twelve subjects during the study. No SAEs occurred during this study. The most common AEs reported during the study were headache (6 times). The remainder were related to fatigue (4), hypoglycemia unspecified (3), dizziness (3), nasopharyngitis (2), cough (2) and lethargy, tonsillitis, abdominal pain unspecified, application site reaction unspecified, sore throat unspecified, injection site bruising, rhinitis seasonal, anorexia, injection site pain, all with an incidence of 1. None of the AEs were of severe intensity. The majority of AEs were mild in intensity with possible relationship to study treatment, equally distributed between the various concentrations of AOD9604 and placebo treatment. The adverse event profile was similar following administration of all treatments.
If there's one thing that science has definitively said about AOD9604, it is that it is safe and has no side effects. Calzada, after trying the peptide out as an anti-obesity and anti-arthritic, has succeeded in having the peptide declared "Generally regarded as safe" by the FDA, which makes it legal to use as a food additive in America. Calzada, seemingly under no pretense that their product has pharmaceutical properties, is now trying to break into the US over the counter supplement and "Nutraceutical" market with AOD9604 (2,4). Interestingly, the compound has only been approved for use in levels of up to 1mg per day (2), whereas the doses used in trials generally hovered around 500ug/kg (5,6), which means a 100kg person was receiving 50mg of the peptide daily. There is no science behind the peptide, or the dosage, and Calzada themselves have previously said AOD9604 is not effective orally (2).
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Other peptides amplify the body’s response to its own testosterone site-specifically within muscle and bone only. Steroids, on the other hand, produce their highly desired anabolic effects by acting on these receptors, but also come coupled with the less-sought-after side effects of acne, oily skin, hair loss, aggression, breast enlargement and testicular shrinkage. It is for this reason, these amino acid chains are serving as an increasingly popular alternative to steroids amongst aesthetic gym goers, providing many of the anabolic effects without the unwanted side effect profile.
Endurobol (GW501516): Classified under a group of drugs called peroxisome proliferator-activated receptor (PPAR) agonists, Endurobol’s potential abuse in athletes is based on animal studies that showed it could improve endurance, increase fat metabolism, improve glucose uptake in skeletal muscle tissue, and increase in muscle gene expression. At the moment, there is insufficient evidence for these sport performance outcomes in humans. Human side-effects are currently also unknown. Endurobol is prohibited both in and out of competition under WADA’s Prohibited List.
A large difference between steroid hormones and peptide hormones is that some steroid hormones exhibit oral activity, in that they can be active after they are taken by mouth. However, many peptide hormones are digested in the same way as proteins. They are broken down into amino acids in the digestive system, which means they no longer have the bioactivity of their parent compound. Consequently, they may require administration through injections.
Example 2 - Morning Injection ◦Wake up and inject your HGH Frag 176-191 (250mcg to 500mcg is a good dosage depending on your budget). ◦Wait as long as possible before having your first meal (the longer you wait the more fat you will burn). ◦When you do eat, try to make the meal high protein, low fat and low carbohydrate (example meat and salad/vegetables). ◦If possible, try to do some cardio in the hours after your injection to increase the fat burning effect.
I have no direct personal reports on effect of the compound. There have been a few reports put out on the Internet, but I have no better ability to summarize such findings than anyone else and generally don’t go by that, except of course I do give credence when there’s a clear, large body of results. That’s not the case here, and what there is, is certainly not in the direction of this being the next wonder.
Although growth hormone and growth hormone releasing hormones are classified as prescription drugs, there is a safe and legal way to increase your levels of hGH production. There are a range of growth hormone supplements designed to boost hGH production within normal limits. For more information, please refer to our “Natural Growth Hormone Supplements Guide”.
It is also notable that the rise in absolute concentrations of ANP and Nt‐proANP after weight loss surgery was comparable to that observed with a 2‐L saline infusion. This observation suggests that the magnitude of obesity‐induced alteration in natriuretic peptide production is physiologically relevant. The slope of the natriuretic peptide response to saline challenge was similar before and after weight loss, suggesting that obesity does not blunt the responsiveness of the natriuretic peptide axis to salt challenge, but rather alters the “set point.”
2. If HGH can be obtained legally from a physician for anti-aging it's extremely expensive, with 10iu (units) costing as much as $200USD. As a comparison, the 10iu equivalent of GH releasing peptides (approximately half of one vial) sells online for approximately $20USD, a full 90% cheaper than actual HGH for the same, if not better, positive effects on the body.
Id do 150mc of ghrp2, 20min later 2-5iu of GH ( as much as you can afford) then be taking albuterol all day long with 25mcg of T3. Peptides fell off the map 1-2 yrs ago, all the good suppliers began to put of shit. Once upon a time you could get LR3 for under 100 bux............like legit stuff. igf DES was around for another year after LR3 went bunk with 95% of places.
Causing one to be " hungry as a wolf " and having a strong gastric motility, this 1er injectable peptide is interesting for fitness practitioners who may require support to finish their carefully prepared meals. This sudden increase in appetite that occurs around 20 minutes after the injection is related to the fact that GHRP-6 stimulates the release of a digestive hormone, Ghrelin, which is designed to cause hunger pangs. This makes it a valuable ally in weight gain treatments , which is important.
Aging often comes with many undesirable effects on our bodies including increased fat, decreased muscle muscle mass and low energy. Some of these issues can be caused by adult growth hormone deficiency. Peptide therapies provide a healthy option to reinvigorate the natural release of growth hormone in the body and reverse the negative effects of aging.
I stopped the colostrum and my ” symptoms ” subsided, seems I have a moderately enlarged prostate which doesn’t run in my family on either side, my question is could the colostrum possibly cause the prostate to enlarge due to the igf-1 at a certain age,? due to a possible decline in testosterone, or could the benefits of colostrum outweigh the prostate issue?
CJC 1295 has shown some amazing results as a growth hormone releasing hormone (GHRH) analog. Not only has CJC 1295 shown potential to increase growth hormone and IGF-I secretion and effects, but it has been able to do so in very large amounts. CJC 1295 Stimulates Growth Hormone Secretion, and will keep a steady increase of HGH and IGF-1 with no increase in prolactin, leading to fat loss, and increased protein synthesis thereby promoting growth.
CJC-1295 is basically a peptide hormone that acts similar to growth hormone releasing hormones (GHRH). Invented by a Canadian biotechnology company called ConjuChem, it is beneficial to athletes because it can bioconjugate with circulating albumin and increase the time it can be used for medical purposes. It achieves this by preventing degradation of its amino acids. With a single dose, it can remain in the body for quite a few days and can cause the growth hormone to be released many times per day. This reduces the frequency of injections needed.
Two submissions were received, both in relation to AOD-9604. One submission did not comment on the scheduling proposal, but wished to inform the committee that the substance is an ingredient in cosmetic products being sold overseas, has an International Nomenclature Cosmetic Ingredient (INCI) name of 27701 sh-Oligopeptide-74 and is published in the International Cosmetic Ingredient Dictionary and Handbook as well as the International Buyer's Guide.
As an athlete, you can also increase your dosage cycle for a period of 12 to 16 weeks at a time, to maximize your gains. Do so gradually if you opt to go this route. Make sure you increase your daily dosage (1 to 2 doses per day, etc.) gradually. Start off with lower dosage levels as well, and see how it interacts with your body. You don’t want to experience withdrawal, nor do you want to experience negative side effects when using Ipamorelin for longer dosage cycles. So, make sure you monitor your progress, see how you feel as you go, and make notes if/when you do experience negative side effects, so you can balance down to the proper dosage levels.
Ipamorelin is very similar to the growth hormone releasing peptides (GHRPs) GHRP 2 and GHRP 6 in that it mimics ghrelin (the hunger hormone) and targets a specific HGH pulse. However, unlike other GHRPs, this peptide doesn’t affect the release of cortisol, acetylcholine, prolactin and aldosterone thereby minimizing side effects experienced with other GH therapies, such as increased hunger. Because there are virtually no negative side effects, Ipamorelin can be prescribed more aggressively and more frequently than other therapies without the risk of elevated cortisol and acetylcholine blood plasma levels. This helps optimize HGH levels for a longer period of time, leading to more successful health outcomes.
During the hydrolysis process, whole proteins are broken down into smaller peptide fragments. These can sometimes be as short as two or three amino acids in length (known as di- and tri-peptides). The benefits of hydrolysed protein have been outlined in detail elsewhere. In short, hydrolysed proteins are much faster absorbed than other forms of protein. It has been shown that hydrolysed whey protein can increase the time of recovery compared to whey protein isolate (WPI) (Buckley et al, 2010).
Getting enough sleep is essential to feeling good – and losing weight. “It’s not so much that if you sleep, you will lose weight, but if you are sleep-deprived, meaning that you are not getting enough minutes of sleep or good quality sleep, your metabolism will not function properly,” explains Michael Breus, PhD and the clinical director of the sleep division for Arrowhead Health in Glendale, Ariz.
We found that BNP and Nt‐proBNP concentrations were also substantially higher after weight loss surgery, both before and after saline infusion. We did not observe an acute rise in BNP or Nt‐proBNP in the first 3 hours after the saline infusion. The longer half‐lives of BNP and Nt‐proBNP may be one explanation, as these peptides may take longer to peak.16 However, we have noted a similar lack of increase after up to 8 hours of observation.17 Thus, we expect that the changes in BNP associated with surgery are likely to be substantially larger than any change induced by saline, even over longer periods of observation.
Raising GH levels with any peptide would accelerate fat loss obviously but if looking at strictly fat loss HGH frag 176-191 and AOD9604 (frag 177-191) are the fat loss peps. They are the part of the HGH amino acid sequence that initiates lipolysis. I personally like Hexarelin dosed 3x a day, it is the strongest ghrp and doesn't have any effect on hunger so it works great for fat loss and dieting for me.
Gamma-Oryzanol (γ-Oryzanol): An antioxidant extracted from rice bran oil, wheat bran and some fruits and vegetables, γ-Oryzanol has been used as an alternative medicine in the treatment of high cholesterol, symptoms of menopause and ageing, mild anxiety and stomach upsets. Although it is used in sports to apparently increase testosterone and growth hormone levels, as well as improving strength during resistance exercise training, there is not enough evidence to determine its effect on hormone levels in humans. Even though animal studies suggest that γ-Oryzanol might actually reduce testosterone production, it has been marketed to, and used by, body builders and strength-training athletes in the hope of boosting strength, increasing muscle gain, reducing body fat, speeding recovery and reducing post-exercise soreness. γ-Oryzanol is not banned by WADA.
By increasing our own growth hormone levels (which normally decrease as we age), there is an increase in protein synthesis which subsequently stimulates muscle growth. It leads to an increase in muscle mass, an increase in fat metabolism (fat loss), and increase in physical strength. It is also helpful in skin ageing, and effective in reducing wrinkles.
Diets on point! 6 600 calorie meals totaling 200-300g protein, 50-150g carbs and almost NO fat. I do get a little fat in my diet from flax, trail mix and what not but all my food is natural, whole and as close to organic as I can get.. TONS of raw veggies. NO cardio atm, Ive got some bad injuries and issues developed from my last cycle so I take it pretty easy LOL. Maybe an hour on the bicycle 1-2x/wk.. Tough job tho so at work 8hrs a day working on diesel pile hammers keeps my heart rate pretty high all day
We supply Australian-made peptides manufactured by licensed compounding facility. Only the highest quality assurance and quality control measures are adhered to in these state of the art facilities to ensure precision, purity, accuracy and sterility. Each and every batch is thoroughly tested and is accompanied by a certificate of analysis available upon request.