For GH to exhibit its fat burning effects, insulin must NOT be present. Insulin release in the body is caused mainly by consuming carbohydrates, although all types of macronutrients (carbs, fat and protein) still cause the release of insulin to some extent. Since HGH Frag works by causing the body to break down and release stored fat for use as energy, if you have recently consumed calories (food or beverage) your body will just use that for energy instead and little extra fat will be burnt. If however there is no food present for the body to use as energy, it will use the stored fat which the HGH Frag has caused to be released and you will notice reductions in body fat over the ensuing weeks.
Aging often comes with many undesirable effects on our bodies including increased fat, decreased muscle muscle mass and low energy.  Some of these issues can be caused by adult growth hormone deficiency.  Peptide therapies provide a healthy option to reinvigorate the natural release of growth hormone in the body and reverse the negative effects of aging.
This peptide is a modified fragment of hGH which contains the portion of the molecule that is believed to be responsible for hGH’s anti-obesity effects. The peptide has been shown to increase fat burning without the increase in blood sugar and growth rate that has been seen with hGH itself. AOD 9604 has been deemed safe for chronic use by the FDA, receiving Human GRAS status in 2014. In addition to its utility as an anti-obesity peptide, AOD 9604 has been shown to have very favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157.

Note: If you are a person concerned about loss of muscle mass, you can consume a small amount of protein every 2-3 hours (amino acid tablets such as EAA and BCAA are good for this purpose and can be purchased from any health food shop or ordered online). However there is little reason to be concerned about muscle loss because when fat is available for energy, such as following HGH Frag 176-191 injections, protein and therefore muscle mass are spared.


One combination of natural supplements that boost IGF-1 with no injections required would simply be a one-two combo of whey protein and colostrum. Throw small bits of natural dairy into the mix and you’ve got a pretty potent trilogy for not just increasing IGF-1, but also all the fat loss, lean muscle gain, and cellular repair mechanisms that accompany a surge in growth hormone.
When taking Ipamorelin, you want it to be pushed through your system naturally, and at the same levels. If you are constantly altering the times you take it, or increase/decrease dosages during your cycle, this is not going to be attainable. To maximize the benefits and gains you are going to experience, dosage levels should be consistent, as should the timing of the dosage you are taking each day.
Another benefit of collagen supplementation to your workout routine? Collagen contains high amounts of the amino acid arginine, which changes into nitric oxide to help our blood vessels relax and promote healthy circulation. Additionally, arginine has been found to help promote total strength and recovery in adult males (4). Adding collagen into your daily diet can help keep your bones strong, helping you to stay active and healthy.
The four groups showed different gross morphological damage and histopathological changes in the cartilage of the lateral part of the femoral condyle (Figure 3). Complete disorganization of articular cartilage with apparent cloning of chondrocytes in the transitional and radial zones was evident in Group 1 (Figures 3-A,E,I). Abnormal gross morphological and histopathological changes such as fibrillated and irregular cartilage surfaces, disappearance of surface-layer cells, and slightly diffused cell growth in the transitional and radial zones were observed in Group 2 (Figures 3-B,F,J). Erosion of the articular cartilage, cleft, and cell cloning in the transitional and radial zones were noted in Group 3 (Figures 3-C,G,K). Softening of articular cartilage and surface irregularities were noted in Group 4 (Figures 3-D,H,L).

Comparing everything else is hard due to branding... don't want to start going into branding for obvious reasons. GH is incredible for fatloss but some brands add so much water it is hard to see the results to begin with. But due to the high serum and igf-1 from gh excellent results are to be had. Many factors come into play though which I am sure your well aware of. I think the ghrp's (2 and 6 for example) are excellent for fatloss if you keep up with the 4 daily injections in your research. Otherwise they are nowhere as effective due to the short peak times... so one must be organized and disciplined to get the full benefits.

This duration is a sufficient time to allow the ghrelin peptide to work through your system, and also for it to have a long lasting effect with continued use. It will work to enhance the hormone system, increase the metabolic rate, and increase lean muscle tissue levels in this period of time. As discussed above, the proper dosage for new users is 200 to 300 mcg daily, at the same time each day. For more experienced users, you can take the same dosage, 2 to 3 times a day (remember that it is the same time each day, and is best to use your injection after a meal for the best results possible).

The most common goal of people in the health and fitness world is to lose weight. Not only do hundreds of millions of people go on diets to try and lose weight every year, but they want to lose weight as fast as possible. It’s no wonder the weight loss industry is a $20 billion industry, with the sales of books, diet drugs, and weight-loss surgeries fueling revenue as people try and lose unwanted weight once and for all.


Molly Hunsinger is a communications professional and certified group exercise instructor and fitness trainer. Her medical, health and fitness industry background spans nearly three decades with experience working as an instructor trainer, staff trainer, facility manager, group exercise program manager, physician relations manager and marketing director. As a media professional, she has developed and launched award-winning allied marketing and advertising campaigns for luxury retailers, leading nonprofit organizations and foundations and written numerous articles and blogs for both digital and print publications. Molly holds a bachelor’s degree in mass communications from the University of South Florida with a concentration in journalism and digital media studies.

In lean animals, neither AOD9604 nor hGH had any effect on epididymal white adipose tissue mass or expression ofβ 3-AR RNA, indicating that in lean animals, this fat tissue is not a major target for these drugs in this study. In contrast, the mass of BAT in lean animals was reduced by both hGH and AOD9604, and β3-AR RNA expression was increased by both these compounds. This could possibly suggest that the increased expression of β3-ARs in brown adipocytes sensitizes catecholamines to dissipate heat.


The ACMS recommended listing Growth Hormone Releasing Hormones (GHRHs), Growth Hormone Secretagogues (GHSs), Growth Hormone Releasing Peptides (GHRPs) as well as new individual substance entries for CJC-1295, ipamorelin, pralmorelin (Growth Hormone Releasing Peptide-2), Growth Hormone Releasing Peptide-6, hexarelin and AOD-9604 in Appendix D, Item 5.
If there was a magic pill that could help improve digestion and gut health, erase wrinkles, ease joint pain and give you healthy, thick hair and nails, I would buy it by the truckload. After all, while boosting my overall health is a priority, having shinier hair and minimal crow’s feet is a major bonus. Although there’s no such magic pill, there is a supplement that promises these results and more—collagen peptides.
Just as you could eat more calories than you think if you aren’t keeping track, you might miss some positive results of your efforts if you aren’t tracking your progress. Weigh yourself weekly. Take body measurements of your waist, legs, chest, and arms every other week. Measure your body fat percentage. Take photos of yourself once a month. Sometimes the scale won’t show results from week to week, but if you have all of the other methods of tracking in place, you’ll be able to see your efforts are being rewarded.
•If injecting just a GHRP or GHRH product on their own, avoid eating/drinking anything high in fat for 3 hours before your injection and anything high in carbohydrates for 2 hours before (i.e. always do your injection on an empty stomach), otherwise the amount of GH release they cause may be significantly blunted leading to poor results. •If injecting both a GHRP and GHRH together (e.g. 100mcg of both GHRP-6 and Modified GRF 1-29) studies have proven that their ability to release GH returns to full-strength as little as 1 hour (60 minutes) post-meal. This gives users greater flexibility with their meal timings, especially since consuming sufficient calories is so critical to building muscle. •Whether injecting GH peptides alone or along with others, always wait at least 20 minutes after your injection before consuming anything. Once at least 20 minutes has passed, consume a food/beverage high in protein and/or carbohydrates to stimulate an insulin spike (if you inject in the morning and around your workout, this meal/shake should be high protein and high carbohydrates, if you inject at night this consumption should be protein only as protein is sufficient enough to spike insulin, but without the negative impact on fat gain which carbohydrates can contribute to).

There is much confusion about the significance of the banned peptide at the centre of the AFL doping scandal - and perhaps that is not so surprising. The company behind AOD-9604 knew back in 2007, after six clinical trials of 925 patients, that the drug had completely failed to treat obesity. But after burning through some $50 million developing the drug, Metabolic Pharmaceuticals Pty Ltd, which owns the patent, has continued to spruik its so-called body-enhancing benefits.


After the commencement of active treatment, 78.7% of subjects experienced at least one AE, with the incidence ranging from 75.6% to 83.2% across all treatment groups (83.2% placebo group; 75.6% 0.25 mg AOD9604 group). There was a high incidence of infections and infestations (46.8%, mainly nasopharyngitis, 17.1%), nervous system disorders (30.1%, mainly headache, 25.9%), musculo-skeletal and connective tissue disorders (25.5%, mainly back pain, 8.2%), and gastrointestinal disorders (22.9%, mainly diarrhea, 7.8%). Although the percentage of subjects experiencing AEs in these body systems is higher than in the run-in period there was no obvious pattern with respect to treatment received, suggesting that the increase was likely due to the longer period of assessment in the active treatment phase.
Like everything in life, you need to be careful. Too much of a good thing can be bad. Water and oxygen are essential for survival, however in excessive amounts be prepared to have ‘000’ on standby. The same principal is true for any drug or peptide. When used at the recommended dose, clinical trials have proven peptides to be effective with minimal side effects, if any. In addition, the body even has its own natural feedback mechanisms in place to downregulate high levels.
For example, if 100mcg more were to be administered after the first 100mcg (making the effective dose of 200mcg), then the second dose will achieve only 50% of what the first dose already did. A 100mcg more (making a total of 300mcg) will achieve only 25% more of the initial dose. This implies that, in order to increase the effect of the compound, only a little more of it can be successfully administered after the saturation dose.
Design Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint. Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4–7 weeks after the first intra-articular collagenase injection. The degree of cartilage degeneration was assessed using morphological and histopathological findings, and the degree of lameness was observed at 8 weeks after the first collagenase injection.

Managing your weight is a hard task no matter your age. But as we age there are extenuating factors that make weight loss even harder. Lifestyle factors, having a desk job, less physical activity, hormone changes e.g. insulin sensitivity or sleep deficiency. While exercise and healthy eating are vital for weight loss, sometimes that’s easier said than done! That’s where we come in. You set the Resolution and we find you the Solution!

SARMs are selective androgen receptor modulators. Androgens are naturally occurring hormones—such as testosterone—that regulate the development and maintenance of male sex characteristics. SARMs provide the benefits of anabolic steroids (i.e., increased muscle mass/strength, fat loss, increased bone density, increased libido) without the quantity and/or severity of unwanted effects. SARMs are not toxic to the liver, separating them from most oral steroids and making them an attractive treatment option to those looking to benefit from anabolic steroid drugs.
In June 2007, the NDPSC decided to extend the exemption from the limit on paracetamol combinations being allowed as general sale products to include phenylephrine (as long as it also qualified as exempt from scheduling through the phenylephrine entries). At that time, the NDPSC considered that the safety profile of these substances was such that allowing a fixed combination to be unscheduled was reasonable.

Mean gross morphological and histopathological scores in Group 1 were significantly higher than those in Groups 2, 3, and 4 (p<0.05). Mean gross morphological and histopathological scores in Group 4 were significantly lower than those in Groups 2 and 3 (p<0.05). However, there are no differences between the mean gross morphological and histopathological scores of Groups 2 and 3 (Figures 4 and 5).


Hey Elvia, do you think that using DAC for short periods of time at your proposed dose is still effective for fat loss? Say for four weeks at 4mg a week? I know peptides need to be used for awhile before effect can be seen. I was thinking about doing 4mg a week for 4 weeks with Injectable l-carnitine for my last 4 weeks before summer haha. In your experience is it worth it to spend the money on the DAC for such a short period?

TGA evaluator concluded that the consistent absence of any clinically meaningful effects on blood pressure (BP) or heart rate (HR) in the applicant's bioavailability studies, and the absence of any ADR reports of BP, HR or other cardiovascular problems, indicate that "there is no valid reason for concern and no need to take any regulatory against the combination products currently in the ARTG and available in the Australian market", i.e. no demonstrated safety risk, and no evidence provided of efficacy of paracetamol 1000 mg / phenylephrine HCl 5 mg adult dose.


Echocardiograms were performed before and after saline infusion at both the baseline and post‐gastric bypass surgery visits. Each subject had four echocardiograms in total during the entire study. Interpretations were made by investigators blinded to clinical status (before or after saline infusion, before or after surgery). The following standard measures were made on two‐dimensional (2D) images in each echocardiogram: interventricular septal and posterior wall thickness (IVS and PWT), left ventricular internal diameter at end‐diastole and end‐systole (LVID, LVIS) and left atrial anteroposterior diameter (LA Dia) in the parasternal view, left ventricular (LV) volumes using a modified Simpson's rule (apical 4 chamber and 2 chamber views), mitral inflow E and A velocities and E deceleration time, and mitral annular early diastolic (e′) velocity at the lateral annulus. We did not calculate left atrial volumes due to limited echocardiographic windows in severely obese patients. Estimation of left atrial filling pressure was obtained every 20 minutes during the second hour of the infusion by determining the ratio of the early diastolic mitral inflow velocity to the early diastolic mitral annular velocity.15
Both paracetamol and caffeine are regarded as being well tolerated when used at therapeutic doses and there is a low risk of serious expected or serious unexpected adverse events with these products when taken either alone or in combination. Clinical data demonstrate that paracetamol combined with caffeine significantly out performs paracetamol alone. Paracetamol/caffeine formulations are well established globally. Such formulations are marketed in over 90 countries and have been available unscheduled ranging from 14 years to 25 years. Cumulative post-marketing experience to date with the sponsor’s paracetamol/caffeine combination products is estimated to be in excess of 488 million patients and has revealed no adverse safety signals or reasons for concern with the use of this product in an open sale environment.

Five of the submissions did not support the proposal while the sixth submission did. The former contend that potential risks of inadvertent use of caffeine in those at risk of an adverse event will be increased if selection of an analgesic is made without the assistance or intervention of a healthcare professional. There was also concern that the proposed exemption may result in an increase in liver damage due to excessive consumption of such a product. This was likely to result from people abusing these products as a source of stimulants.


AOD aka Advanced Obesity Drug., Fat Loss Peptide AOD 9604 consists of the get along 15 amino acids of the human wealth hormone molecule. The considerable thing close but no cigar AOD 9604 is it has no doom on accomplishment or insulin resistance. With an fine safety sketch of minimal side chattels personal, AOD 9604 has been proven more effective than consequently occuring Growth Hormone at fresh the collapse of fat. Studies have proven its efficiency to reduce biggest slice of the cake full, by way of explanation in the abdominal area.
It does not matter what your intended use it; whether it is for weight loss, muscle mass development, lean muscle mass, or simply to increase HGH to their natural levels, you should always maintain the same dosage levels throughout the entire cycle. Do not increase use if you believe you aren’t achieving the results you are hoping for, as this can result in negative side effects or lacklustre results.
One of the important reasons we consume protein is that it helps to keep our bodies full. While many people use protein powders for this purpose, a lot of protein powders are filled with fillers or unnatural additives. Collagen protein, on the other hand, is a clean protein - in its pure form, it has no additives or sweeteners - that can help keep you full and promote satiety. Several studies have focused on the benefits of consuming collagen in helping people who are trying to lose weight. In a study assessing hunger hormones in 10 obese patients and 12 patients of normal weight, researchers found that the intake of gelatin (a substance derived from collagen itself) actually increased the satiety hormone, which means the subjects were more likely to adhere to their weight loss diets(1). If you could maintain satiety longer, you may be on the road to effective weight loss simply by reducing your own hunger.
Cartilage loss in OA is caused by proteoglycan depletion and chondrocyte death that in turn are caused by imbalances between catabolic and anabolic activities within the joint [5]. Growth hormone (GH) has been shown to correct this imbalance [6]. Although the exact mechanism underlying the effects of intra-articular GH injection is not known, GH in the synovial fluid probably enhances proliferation, matrix synthesis, and differentiation of bone and cartilage cells in vitro [7]. Studies have found that GH accelerates healing in animal models of OA [8,9]. However, intra-articular GH injections in humans are known to have detrimental pro-tumor and pro-diabetic effects. These negative effects are caused by the secondarily produced insulin-like growth factor-1 (IGF-1) [10].
From the standpoint of protein synthesis and muscle repair, IGF-1 injections have also been shown to enhance the anticatabolic effects of insulin and to increase the protein synthesis normally induced by growth hormone. This is because, like insulin, IGF-1 encourages amino acid uptake into muscle cells, stimulates peripheral tissue uptake of glucose (which lowers blood glucose levels), and suppresses liver glucose production. That last fact is important and is actually why IGF-1 is even being considered as a diabetes-prevention drug. Insulin resistance can cause the liver to produce excess glucose, which then causes even more insulin insensitivity and can eventually result in type II diabetes, and IGF-1 can decrease the need for this type excessive insulin release.
Also, as we age, our metabolic processes slow down, leading to less background energy consumption. Less exercise promoting muscular strength gets exchanged for walking and taking the stairs. This reduces muscle that burns fat and increases the metabolism again causing fat storage due to lack of activity. The result is obesity, which is now a pandemic.
There are several limitations of our study. Given the nature of our physiologic protocols, which required two large volume saline infusions in obese patients before and after surgery, our sample size was modest. Nonetheless, we were able to elicit significant relationships of all four natriuretic peptides (ANP, Nt‐proANP, BNP, and Nt‐proBNP) across a variety of salt conditions before and after surgical weight loss. Our study population consisted of primarily females. We do not believe from prior epidemiologic studies looking at resting natriuretic peptide levels in obese individuals12 that having more men in our cohort would have modified our findings. Prior epidemiologic studies do not suggest that gender modifies the association between obesity and natriuretic peptide concentrations. We did not examine short‐term changes in the natriuretic peptide system, as a physiologic assessment immediately after surgery would have been impractical and potentially confounded by post‐operative shifts in volume or nutrition. We also focused on surgical weight loss because weight loss with non‐surgical treatments is less consistent. Thus, we cannot exclude any surgery‐specific effects. Because the saline infusion was indexed to BSA, less saline was given at the post‐weight loss visit. This could have created a “conservative” bias, eg, toward observing a smaller natriuretic peptide response after surgery. Indexing was performed to ensure that the amount of saline relative to plasma volume was relatively constant. Lastly, we did not perform a complete assessment of the renin‐angiotensin‐aldosterone system and the sympathetic nervous system, all of which could also be primarily affected resulting in the observed responses of the natriuretic peptide system after weight loss and/or saline loading.
Figure 5A demonstrates that chronic administration of AOD9604 or hGH has no significant effect on the weight of white adipose tissue in either WT orβ 3-KO mice. However, in brown adipose tissue, both AOD9604 and hGH significantly reduced the size of the brown adipose tissue mass in the WT mice (Fig. 5B), by 20% and 31% (P < 0.05), respectively, as was found previously in the C57BL/6J ob/ob mice (Fig. 2B). Importantly, this effect was not observed in β3-KO mice.
The amazing effects of HCG on the hypothalamus were discovered by Dr. Albert T. W. Simeons in 1954, who observed that malnourished women tend to give birth to healthy babies with normal birth weights. Dr. Simeons concluded that women are able to do this because the HCG hormone that their bodies naturally produced during pregnancy helped their bodies to metabolise subcutaneous fat. hCG released by the embryo also helps women with weight redistribution (helps prevent uneven deposits of weight on thighs, abdomen, hips etc) and therefore women concerned with hormonal weight gain are ideal candidates for this diet.
In vitro and in vivo investigations revealed a specific region within the hormone molecule that is responsible for the molecular events associated with lipid metabolism [18, 24, 25]. AOD9604 is a peptide fragment of the C-terminus or lipolytic domain of hGH (hGH177-191), with an additional tyrosine residue at the N-terminal end for stabilization. In vitro and in vivo experiments have shown similar effects of AOD9604 and hGH on lipid metabolism when chronically applied to mice [20, 21]. Interestingly, AOD9604 mimics the effect of hGH on lipid metabolism, without having growth promoting or pro-diabetic effects. The safety and tolerability of AOD9604 has been studied in the human clinical trials described in this paper.
AOD9604 is a peptide fragment (hGH Fragment 177-191) of the C-terminus of Human Growth Hormone to which a tyrosine is added at the N-terminal end.  Studies have suggested that AOD9604 is more effective than its predecessor AOD9401 in its ability to stimulate lipolytic (fat burning) and anti-lipogenic activity. Like Growth Hormone, AOD9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (prevents the transformation of  fatty food materials into body fat) both in laboratory testing and in animals and humans.  Recent  clinical research studies have shown that  AOD9604 did show a reduction of body fat in the mid abdominal area in both obese, over-weight, and average built people.
You’ve already learned that sufficient protein intake (above 0.5g/lb of body weight) can assist with adequate IGF-1 and growth hormone production. Whey protein provides your body with a complete profile of necessary amino acids, including leucine. Leucine is an amino acid that promotes greater muscle protein synthesis and assists the body while gaining lean muscle mass and losing fat tissue simultaneously.
Example 1 - Night Time Injection (recommended) ◦Ensure you do not eat or drink anything containing calories within three (3) hours of going to bed (with the exception of water, diet sodas, coffee/tea with artificial sweeteners). ◦Take your HGH Frag 176-191 injection just before getting into bed and your body will therefore be burning stored fat for the duration of your sleep. ◦If possible, do some cardio first thing in the morning and wait as long as possible before having breakfast to allow the fat burning to continue throughout the morning/day.
I have not used IGF-1 but I have used a stack of Ipamorelin and CJC 1295 no DAC. I did not do any lab tests before, during or after but definitely noticed increased fat loss and better sleep. I was not trying to increase muscle so there was no change to speak of for me. But you are not recommending their use even without IGF-1, is that correct? I do not compete in anything so WADA is not a concern.
AOD9604 is a new synthetic peptide fragment that comprises a modified 15 amino acid region of GH with a tyrosine component to help stabilize the molecule. Similar to GH, AOD9604 aids weight reduction in rodent models of obesity and was originally developed for the treatment of obesity in humans [11]. Additionally, it does not stimulate the production of IGF-1 [10], has positive effects on the differentiation of adipose mesenchymal stem cells into bone, and was found to promote proteoglycan and collagen production in isolated bovine chondrocytes in an in vitro study by Metabolic Pharmaceuticals (patent applied [WO2013082667]). Its positive effects include promoting the repair of bone and cartilage in cases of OA.
Just as you could eat more calories than you think if you aren’t keeping track, you might miss some positive results of your efforts if you aren’t tracking your progress. Weigh yourself weekly. Take body measurements of your waist, legs, chest, and arms every other week. Measure your body fat percentage. Take photos of yourself once a month. Sometimes the scale won’t show results from week to week, but if you have all of the other methods of tracking in place, you’ll be able to see your efforts are being rewarded.
When you buy peptides online through Peptide Clinics you can be ensured of our commitment to your success. Peptide Clinics specialises in supplying premium peptide supplements, incorporated into custom treatment programs to assist you in meeting your health and fitness goals. All new client questionnaires are screened by one of our highly trained and experienced medical doctors. All initial and follow-up blood tests are also screened by our doctors, who use this information to recommend the peptide best suited for you, with its dose and frequency. Programs are customised on a per client basis dependent on your goals and blood test results, which are regularly reviewed and modified to ensure optimal peptide performance.
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