A NOTE ABOUT RELEVANT ADVERTISING: We collect information about the content (including ads) you use across this site and use it to make both advertising and content more relevant to you on our network and other sites. This is also known as Online Behavioural Advertising. You can find out more about our policy and your choices, including how to opt-out here.
When people are on a mission to lose weight one of the first things they do is head to their treadmill and remove all of the clothing they’ve been storing on it while it wasn’t in use, to start a cardio work out. Or, maybe you’ll go out for a bike ride or jog around town.  Cardio exercise burns the most calories, which helps you create a calorie deficit that you need for weight loss. But people generally over estimate how many calories they’re actually burning through exercise and end up over eating because they assume they’ve burned the calories.

When combined with the other IGF-1 and growth hormone boosting strategies you’ve just discovered – such as eating adequate calories, heavy weight training, 7-9 hours of sleep per 24 hour cycle, adequate mineral intake and moderation of alcohol intake – these additional strategies will ensure you get all the anabolic effects of IGF-1 and growth hormone without having to resort to needles, syringes, prescriptions, online pharmacies and potentially dangerous self-experimentation.


A study research coordinator screened charts for eligibility from a pool of patients who were referred to the weight center of the Massachusetts General Hospital for Roux‐en‐Y gastric bypass surgery. Eligible patients were informed about the details of the research protocol, including the need for 2 saline infusion visits at the Clinical Research Center (CRC) 6 months apart. A study physician investigator verified the medical history of study participants including the use of medications at the time of the saline protocol visit. The subjects were asked to keep a detailed diary of all the food and beverages consumed for the 48 hours prior to each study visit to estimate their nutritional status.

IGF-1 is the only natural hormone that can stimulate lean muscle mass gains and help the body choose to burn stored fat over simple glucose for fuel, meaning, you will burn off more fat. Studies demonstrate that only colostrum supplements containing lactoferrin can produce lean muscle gains that complement IGF-1 supplementation. That’s because it is actually the lactoferrin in some brands of colostrum that work to increase muscle mass and to burn adipose tissue. In fact, in a recent 2013 study, participants who supplemented with lactoferrin over a period of eight weeks experienced increased weight loss, reduced visceral and subcutaneous fat, reduced waist circumference, and reduced hip circumference.


Peptides are not to be confused with synthetic human growth hormone drugs, which are injected into the bloodstream to provide rapid results. HGH is said to be Hollywood's secret weapon, with top stars, filmmakers and studio execs hooked on the youthful effects, but synthetic hGH is tightly regulated in Australia and verboten unless there's a proven growth hormone deficiency (most cases are in children).

Despite its announcement to the stock exchange in 2007 that trials showed at 24 weeks participants lost one kilogram at best, only last month Metabolic told its patent holders that it was going ahead with attempting to license the product in the US for use in sports drinks and dietary supplements. It is also pursuing commercial opportunities in the veterinary industry. This is after its chief, David Kenley, admitted several months ago that there is no proof it had any body-enhancing effects in humans.
In ob/ob mice, both AOD9604 and hGH reduced both white and brown adipose tissue mass and increased β3-AR RNA expression. This suggested that an elevation inβ 3-AR RNA expression is associated with increased fat metabolism and a reduction in the fat tissue mass in the ob/ob mouse model. Obese mice have lower levels ofβ 3-AR expression in their adipose tissues than lean mice, shown in this study and others (14). The ability of AOD9604 and hGH to increase the level ofβ 3-AR RNA expression in obese mice to a level that is comparable to those in lean mice is an exciting finding. However, it must also be considered that both hGH and AOD9604 may influence the expression of other members of the adrenergic pathway, such as the β1-ARs, hormonesensitive lipase, and signaling proteins, which are all expressed in adipose tissue and associated with lipolysis. The importance of the change inβ 3-AR expression with AOD9604 and hGH in humans is not established and will depend on the use of potent and selectiveβ 3-AR agonists that are active at the human receptor.
These “protein chains”, are not just turned to by gym junkies for their muscle synthesising and fat burning properties. With peptides for injury recovery and repair, cognition, anti-aging, sleep, tanning, improving libido, or anxiety, to name a few, this growing market caters for everyone. Unfortunately, there has been a lot of stigma in the public eye due to media and press, shaming their use and clouding potential in debilitating chronic conditions such as obesity, muscle atrophy, osteoarthritis, dementia, Alzheimer’s or even recovery post stroke.
These results also demonstrate that, unlike hGH, AOD9604 has no negative effect on carbohydrate metabolism. This was previously demonstrated in mice. Chronic administration of hGH to ob/ob mice depressed glucose oxidation and increase plasma glucose levels. AOD9604 had no such effects, no changes in circulating plasma glucose in either lean nor obese ob/ob mice have been observed [20]. AOD9604 did not cause hyperglycemia or affect insulin sensitivity in rats and mice [18, 20].
Results: AOD9604 had no effect on serum IGF-1 levels, which confirms the hypothesis that AOD9604 does not act via IGF-1. Results of oral glucose tolerance test demonstrated that, in contrast with hGH, AOD9604 has no negative effect on carbohydrate metabolism. There were no anti-AOD9604 antibodies detected in any of the patients selected for antibody assay. In none of the studies did a withdrawal or serious adverse event occur related to intake of AOD9604.

Injections of other compounds along with IGF-1 (which is a popular practice) can also cause serious health issues. The idea is that after an user administers a GHRP (like Ipamorelin) along with IGF-1, a selective pulse is then sent that stimulates the hypothalamus and pituitary to release even more growth hormone. But this may result in an eventual negative feedback loop that leaves you unable to produce your own growth hormone and stuck on injections forever. GHRP and synthetic HGH use has also been shown to cause joint pain, huge spikes in cortisol, excessive hunger, and splitting headaches.

For example, if 100mcg more were to be administered after the first 100mcg (making the effective dose of 200mcg), then the second dose will achieve only 50% of what the first dose already did. A 100mcg more (making a total of 300mcg) will achieve only 25% more of the initial dose. This implies that, in order to increase the effect of the compound, only a little more of it can be successfully administered after the saturation dose.
Obese individuals have been found to have lower natriuretic peptide levels in multiple previous studies.12, 13, 14 The finding of lower natriuretic peptides in obese subjects is unexpected because obesity promotes increased plasma volume and hypertension, which are known to lead to left ventricular stress and hypertrophy. These conditions should trigger natriuretic peptide release from the heart. Thus, it has been proposed that obese individuals may have a primary “natriuretic peptide deficiency”8, 13 that could contribute to the development of hypertension.
Finally, patients deficient in growth hormone who get IGF-1 injections have shown increased rates of fat loss and fat oxidation. One theory for this is that, as you’ve just learned, IGF-1 can suppress circulating insulin, which would allow more burning of fatty acids from fat cells. This makes sense, since we do know that fat cells contain IGF-1 receptors, and this means that IGF-1 can interact with fat cells.
As women age, the #1 reason for weight gain is hormonal imbalance. In fact, hormonal imbalance can lead to unwanted adult acne, loss of sexual desire, and sagging breasts. When you correct this imbalance, you begin to lose body fat, overcome acne, naturally lift and enhance breast tissue, and improve libido! OxySelect Pink was formulated for women by women, and the results are incredible and comes with a 100% money-back guarantee! Read More
The banned "peptide" believed to have been injected into numerous Australian professional athletes can be bought in under 30 seconds online. GHRP-6, the growth hormone-releasing peptide that features in the Australian Crime Commission's report into organised crime and drugs in sport released this morning, was identified -- alongside other so-called performance and image enhancing drugs (PIEDs) -- as a dubious supplement threatening to cast a pall over the country's professional codes. Although unproven, GHRP-6 purportedly helps the body repair damaged tissue and can stimulate human growth hormones to improve athletic performance. It can be used in conjunction with anabolic steroids to promote muscle gain. Peptides are classified as a prohibited substance on the World Anti-Doping Agency prohibited list and were banned for use both in and out of competition in 2008. The ACC report said most peptides are also:

A large difference between steroid hormones and peptide hormones is that some steroid hormones exhibit oral activity, in that they can be active after they are taken by mouth. However, many peptide hormones are digested in the same way as proteins. They are broken down into amino acids in the digestive system, which means they no longer have the bioactivity of their parent compound. Consequently, they may require administration through injections.


CJC-1295 is a fast-acting Growth Hormone Releasing Hormone designed to enhance the body’s natural production and release of human growth hormone and Insulin-like Growth Factor 1 (IGF-1). In doing so, CJC-1295 reverses the age-related decline, generates new muscle cells and increases fat loss. Another great trait of CJC-1295 is its ability to promote slow wave sleep, a deep sleep responsible for the highest levels of cell regeneration, muscle growth and memory retention.
A total of 97 AEs were reported by 17/17 subjects during this study. Most of them were of mild or moderate in intensity, with the exception of two SAEs, one of which (diarrhoea) was deemed “possibly related” to study treatment (54 mg AOD9604) and one (bronchial pneumonia) deemed to be “unrelated” to the study treatment (54 mg AOD9604). The most common adverse event reported was mild or moderate headache followed by events related to the digestive system, specifically diarrhea, flatulence, increased appetite and nausea. There was no observable trend between the AOD9604 groups or the placebo with respect to the incidence. The only event deemed definitely related to the treatment was taste perversion occurring 10 minutes following dose administration of the placebo.
ASADA gave advice to the ACC, and perhaps Essendon, that AOD-9604 was not banned under the S2 category. Given the expectation that AOD-9604 would not be anabolic because it lacked the ''anabolic region'' of HGH, it is perhaps understandable that ASADA did not classify it under S2 in 2011 and 2012, although its close structural relationship to the banned HGH should have been sufficient to include it on the banned list.
When you increase the dosage gradually it is also going to ensure you do not experience all (or any) of the noted side effects which are possible with the use of Ipamorelin. And, if you are taking other peptides, supplements, or growth hormones, it is the best way to ensure they are going to acclimate well and work together well, in order for you to realize the greatest results possible when trying to increase muscle mass, and lean muscle tissue, without putting on body fat in the process.
Serum IGF-1 levels remained relatively constant over the dosing period with no apparent differences between treatment groups. Fasting plasma glucose and serum insulin levels remained unchanged throughout the treatment period. Furthermore, no changes in any of the OGTT parameters were observed from day 1 to day 7 of treatment. There were no study related clinically significant findings in the safety related laboratory tests, vital signs, or ECG measurements.
One proposed mechanism for reduced natriuretic peptide concentrations in obesity is the relative abundance of natriuretic peptide clearance receptors (NPR‐C) in adipose tissue.13, 22 Elevated insulin has also been linked to increased expression of NPR‐C in obese subjects.23 On the other hand, plasma Nt‐proANP and Nt‐proBNP levels are reduced in obesity to a comparable degree as the mature peptides. Because the pro‐peptides are not known to bind to NPR‐C, impaired synthesis or secretion likely plays a role in obesity.
When people are on a mission to lose weight one of the first things they do is head to their treadmill and remove all of the clothing they’ve been storing on it while it wasn’t in use, to start a cardio work out. Or, maybe you’ll go out for a bike ride or jog around town.  Cardio exercise burns the most calories, which helps you create a calorie deficit that you need for weight loss. But people generally over estimate how many calories they’re actually burning through exercise and end up over eating because they assume they’ve burned the calories.
Athletes will greatly benefit from using Ipamorelin. For example, if you use CJC 1295 along with Ipamorelin, the results are going to be even greater. HGH increase will result in greater muscle mass levels, less time for muscle mass to develop, and increased levels of lean muscle tissue. The more peptides your body produces, the greater your lean muscle mass is going to be. And, over time, with gradual increases in HGH, you are going to realize a leaner, more muscular definition to your body.

Thymosin beta-4 (TB-4): A naturally occurring protein found in blood platelets, TB-4 plays a role in the repair and regeneration of injured tissues in the human body. It was first detected in the thymus, a gland that produces white blood cells. While it’s recently been used to treat horses and implicated in horse doping, it’s also found its way into bodybuilding circles. While there is no published evidence that TB-4 produces any benefit to athletes, it was added to the WADA banned substances list in 2011.

But for maintenance of adequate and natural IGF-1 and growth hormone, and to achieve that sweet spot of not becoming to pro-growth while also not becoming a weak, muscle-less noodle, that sweet spot of producing adequate insulin without producing too much, and that sweet spot of increasing cellular repair without letting cellular division get “out of control”, I have indeed been implementing three specific strategies: my IGF-1 “trilogy”.
Metabolic Pharmaceuticals have reported that recent in vitro trials have shown that AOD9604 may stimulate the growth of bone cells, and muscle and cartilage cells. These results have not yet been reproduced in animals or humans (4). There was a lot of speculation that Metabolic was providing AOD9604 to players at the Essendon Football Club as part of a secret clinical trial, but the company has flatly denied this claim, claiming it has not run any human trials since 2007 (2). AOD9604 has been scientifically proven safe and side-effect free (2), and is apparently very difficult to detect in the blood.
The two peptides CJC 1295 Ipamorelin, are often used in conjunction for better results. Known individually as CJC 1295 and Ipamorelin, these peptides have similar roles, which we will look at later. But for now, the CJC 1295 and Ipamorelin combination, is chiefly used together because the production of growth hormone secretion is 10 times more effective than using them individually. This makes it convenient for most users, to guarantee quicker results. Above all, it is popular among athletes, bodybuilders and weightlifters in need of building strength or speeding up the recovery of an injury.
The discovery of the role of Tβ4 in the process of immune regulation has lead to its use as a valuable therapeutic agent. Tβ4 has been used in the treatment of HIV, AIDS, Influenza, colds, and various infections. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following heart attack due to its cardio and neuroprotective effects.
Amongst its metabolic effects, hGH can induce inhibition of lipoprotein lipase activity in adipose tissue, stimulating lipolysis in adipocytes, which results in the reduction of fat cell mass [4-7]. Moreover, a correlation has been found between adiposity and the reduced circulating levels of hGH [8]. When applied systemically, hGH reduces body fat mass and influences fat distribution [9]. Therefore, treatment with hGH should theoretically have a positive impact on obesity. However, long term treatment with hGH is associated with various health risks, including glucose intolerance and insulin resistance, diabetes, acromegaly, cancer, edema, and hypertension [10-13].

Natriuretic peptide measurements were tested for normality and were logarithmically transformed for analysis. We used paired t tests to examine the change in BMI, blood pressure, and natriuretic peptides before and after surgery. Mixed effect models using all non‐missing data from 18 study subjects were used to assess the effects of surgery and intravenous saline and their interaction on plasma Nt‐proANP, Nt‐proBNP, and mature ANP and BNP levels, as well as echocardiographic measures. To account for repeated measures for each subject, a spatial power structure for ANP. Nt‐proANP, BNP, and Nt‐proBNP, and a completely general (unstructured) covariance matrix for echocardiographic outcomes were used. None of the interactions terms were significant and P values reported are based on models without interaction. A secondary analysis after covariate adjustment for age, sex, and blood pressure was also performed. All analyses were conducted using SAS (Cary, NC). A two‐sided P<0.05 was considered statistically significant for the primary outcome.

When you increase the dosage gradually it is also going to ensure you do not experience all (or any) of the noted side effects which are possible with the use of Ipamorelin. And, if you are taking other peptides, supplements, or growth hormones, it is the best way to ensure they are going to acclimate well and work together well, in order for you to realize the greatest results possible when trying to increase muscle mass, and lean muscle tissue, without putting on body fat in the process.


The other submission commented on the consideration to place AOD-9604 in Appendix D. The submission supported listing in Schedule 4, but raised concerns that listing the substance in Appendix D would limit any future development work, including clinical trials that are currently being conducted on the substance. The submitter notes that there are currently 5 clinical trials notified to the TGA using this substance , with these approved clinical trials going ahead on the basis that the substance is safe for human use. Inclusion in Appendix D may place unnecessary burden on those conducting these clinical trials.
Mod GRF 1-29 and CJC-1295 are still being researched. As such, they are not yet medically utilized or approved. Though some firm protocols for the use of these peptides have been developed, the dosage of the compound is not yet medically confirmed. In a study conducted by researchers on 21 to 61 year-old subjects, it was found that depending on the dose, the concentrations of the growth hormone increased to up to 10 times for at least 6 days. Also, the concentration of IGF-1 increased to up to 3 times for 9 to 11 days.
CJC1295 is a 30 amino acid peptide, which primarily functions as a growth hormone releasing hormone analogue (mimicing the effect of GHRH).  It was initially invented to treat deep fat deposits in people, because it is known that having an increase in our own growth hormone levels will target this.It stimulates production of our own growth hormone from the pituitary gland.  
The discovery of the role of Tβ4 in the process of immune regulation has lead to its use as a valuable therapeutic agent. Tβ4 has been used in the treatment of HIV, AIDS, Influenza, colds, and various infections. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following heart attack due to its cardio and neuroprotective effects.
When you increase the dosage gradually it is also going to ensure you do not experience all (or any) of the noted side effects which are possible with the use of Ipamorelin. And, if you are taking other peptides, supplements, or growth hormones, it is the best way to ensure they are going to acclimate well and work together well, in order for you to realize the greatest results possible when trying to increase muscle mass, and lean muscle tissue, without putting on body fat in the process.
Collagen is an important component of our body, making up 90% of our connective tissue and 70% of our skin. Our American diets, and Western diets in general, tend to not include collagen many foods that naturally contain collagen. This is unfortunate because collagen plays an important role in helping us minimize the sign of aging, and it promotes gut and joint health. To remedy this, many people are turning to supplementing with collagen peptides. Not only can collagen supplementation help to rebuild your skin, bones, hair, and gut, but recently we are learning more about how collagen can help us in the fight against obesity.

CJC-1295 and Mod GRF 1-29 are administered in micrograms (mcg) rather than milligrams (mg) – the unit of administration of other steroids and performance-enhancing drugs. It has also been found that a 100mcg dose is enough to fully saturate the receptors in the anterior pituitary. This is called the saturation dose. After a dose of 100mcg has been administered, the subsequent dosages will achieve only half the effect.


It is well known that hGH is associated with increased IGF-1 levels. IGF-1 may have a variety of undesirable effects, including an increase in cancer risk [22, 23]. In the studies discussed herein, IGF-1 levels were monitored in all long-term studies but did not reveal clinically significant differences between dose groups or placebo. Therefore the 5 SAEs that occurred in the 12 week treatment study (three in the AOD9604 20 mg group (basal cell carcinoma, moderate lipoma and squamous cell carcinoma), one in the 10 mg group (malignant melanoma) and one in the 5 mg group (breast cancer)) could not be attributed to increased IGF-1 levels. The Principal Investigator considered none of the reported SAEs to be “possibly”, “probably” or “definitely related” to the study medication. The rationale behind this judgment was that none of the cancer forms occurred in the highest dosage group (30mg AOD9604/day), therefore a dose effect can be excluded. Further examination of the SAE cases indicated that these subjects had neglected their personal medical care for a longer period of time, so that the higher incidence of cancer may well have occurred due to the natural incidence rate of cancer events in the population.
200 to 300 mcg is typically the daily dosage which is recommended for the typical Ipamorelin user. It can be taken anytime during the day but is advisable to be used in the morning, as it will help you achieve the best results in such cases. Regardless of when you start your dosage, it is important to ensure you are taking it at the same time each day. And, for new users, it is best to stick to a one-a-day cycle.
The particle size of a drug molecule is a crucial factor in the effects of intra-articular injections. The larger the particle size, the longer the drug will stay in a joint, thereby increasing its efficacy [20]. The short residence time of intra-articular AOD9604 when dissolved in saline was due to its rapid uptake by local circulation. However, the combination of AOD9604 with HA may result in more residence time and better effects in the joint. Recent studies [21–23] have shown that the addition of HA to nanoparticles improves the drug effects by increasing drug bioavailability and decreasing systemic absorption after topical administration.
Ryan also brings up a good point to bring up the fact that GHRH receptors are typically not desensitized with higher dosing but again not much accomplished with CJC-1295, ,MOD GRF 1-29 where we know the 100mcg is a saturation dose. on the other hand we can desensitize the GHRP receptor if we start increasing the dosing significantly above the saturation dosing  of 100mcg. I think you are fine at a 150 mcg dosing but again how much more benefit are you really getting.
Advanced Obesity Drug 9604 (AOD9604), targets fat metabolism directly by enhancing the breakdown of stored fats and inhibiting the synthesis of new fats. It is a peptide drug derived from the fat-reducing activity of human growth hormone (hGH). hGH has been shown to cause fat reduction, but is not suitable as an anti-obesity drug as it also causes an increase in muscle, organ and bone mass as well as causing diabetes to develop. The effectiveness of hGH declines in older people, correlating with the tendency to put on weight as one gets older. In support of this, the clinical trials so far have shown a greater effect of AOD9604 in the older population.
The company which developed it, Metabolic Pharmaceuticals, did have a small early study done which showed a small amount of fat loss at 1 mg per day but not really any other dosing. Measured effect was less at higher doses. In total the company did at least six studies. According to the lead researcher of five of the studies, Dr Gary Wittert, results were uniformly negative.
For CJC-1295 DAC there are no particular diet restrictions that need to be followed due to its long half-life. For GHRP products the following should be observed as insulin and fatty acids can blunt the release of GH in the body and therefore make your injections less effective: •Avoid eating/drinking anything high in fat for 3 hours before your injection and anything high in carbohydrates for 1-2 hours (always do your injection on an empty stomach). •Wait at least 20 minutes after your injection before eating/drinking anything with calories.
Peptide therapy encompasses numerous different drugs with varied effects, ranging from immune modulation and tissue repair to fat loss and muscle building. Our center has seen very positive results in patients with CFS, Hashimoto’s thyroiditis, Lyme disease, and fibromyalgia, among other conditions. Ask your physician or speak to a patient representative at (877) 508-1177 to find out if peptide therapy is right for you.
When you are just getting started with Ipamorelin, it is advised to use only one supplement daily at the same time each day. It is also advised to begin on the lower end, typically an eight-week cycle, and at a maximum twelve-week cycle. Doing this not only guarantees the desired results when using Ipamorelin, it is also going to ensure you get the most out of the supplement. When using this dosage cycle you will:
The particle size of a drug molecule is a crucial factor in the effects of intra-articular injections. The larger the particle size, the longer the drug will stay in a joint, thereby increasing its efficacy [20]. The short residence time of intra-articular AOD9604 when dissolved in saline was due to its rapid uptake by local circulation. However, the combination of AOD9604 with HA may result in more residence time and better effects in the joint. Recent studies [21–23] have shown that the addition of HA to nanoparticles improves the drug effects by increasing drug bioavailability and decreasing systemic absorption after topical administration.
The discovery of the role of Tβ4 in the process of immune regulation has lead to its use as a valuable therapeutic agent. Tβ4 has been used in the treatment of HIV, AIDS, Influenza, colds, and various infections. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following heart attack due to its cardio and neuroprotective effects.

Growth Hormone (GH) and IGF-1 are naturally occurring hormones in the human body responsible for many enviable aesthetic traits such as muscle mass, leanness and a firm/even skin tone. As people age, levels of growth hormone rapidly decline and this is one of the main reasons humans put on weight, lose muscle mass and develop sagging/uneven skin. It's no surprise then that synthetic Human Growth Hormone is a sought after product for anti-aging by persons looking to remain youthful, bodybuilders looking to put on muscle mass and people in general who are looking to "tone up" or lose stubborn belly fat.

Perhaps. As Dr Larkins weighs in: "It's a different kind of chemical and physiological manipulation that goes way beyond what I'd call conventional hormone therapy. It's the next stage of technology that's come along to try and help people enjoy quality of life." A stage with an effect apparently significant enough to risk a professional athletic career for.
×