Ultimately, it needs to be trialled in athletes. But that would never happen. As a substance with no therapeutic use, there is no need to ever test it to determine its effect on athletic performance. You don't need the same standard of evidence for drugs like EPO (synthetic replicas of hormones), where the primary biological effect studied in clinical trials of non-athletes is clearly and blatantly performance enhancing. With something like AOD9604, the waters are much murkier with respect to athletic performance.
If there's one thing that science has definitively said about AOD9604, it is that it is safe and has no side effects. Calzada, after trying the peptide out as an anti-obesity and anti-arthritic, has succeeded in having the peptide declared "Generally regarded as safe" by the FDA, which makes it legal to use as a food additive in America. Calzada, seemingly under no pretense that their product has pharmaceutical properties, is now trying to break into the US over the counter supplement and "Nutraceutical" market with AOD9604 (2,4). Interestingly, the compound has only been approved for use in levels of up to 1mg per day (2), whereas the doses used in trials generally hovered around 500ug/kg (5,6), which means a 100kg person was receiving 50mg of the peptide daily. There is no science behind the peptide, or the dosage, and Calzada themselves have previously said AOD9604 is not effective orally (2).
In vitro and in vivo investigations revealed a specific region within the hormone molecule that is responsible for the molecular events associated with lipid metabolism [18, 24, 25]. AOD9604 is a peptide fragment of the C-terminus or lipolytic domain of hGH (hGH177-191), with an additional tyrosine residue at the N-terminal end for stabilization. In vitro and in vivo experiments have shown similar effects of AOD9604 and hGH on lipid metabolism when chronically applied to mice [20, 21]. Interestingly, AOD9604 mimics the effect of hGH on lipid metabolism, without having growth promoting or pro-diabetic effects. The safety and tolerability of AOD9604 has been studied in the human clinical trials described in this paper.
We identified 34 patients who met eligibility criteria based on the chart review. Two subjects were excluded because they were found to have diabetes requiring insulin therapy, 1 was excluded because of hypothyroidism, and 13 were excluded because they did not undergo gastric bypass surgery or did not wish to participate. A final study sample of 18 individuals (15 women) was enrolled into the protocol. We had 3 individuals who did not complete the 6‐month follow‐up visit; the sample that completed both visits consisted of 15 individuals (12 women). No subjects were excluded because of peri‐operative complications. Table 1 displays the characteristics of the study sample at baseline and 6 months after surgery. From baseline to 6 months after surgery, subjects had a mean decrease of 27% in body mass index (P<0.0001). There were significant reductions in mean arterial blood pressure (P=0.004) and heart rate (P<0.001) after surgery. Only 2 out of 18 subjects were on any class of anti‐hypertensive medications at the pre‐op visit before gastric bypass surgery. At the 6‐month visit, anti‐hypertensive medication was discontinued for one of these subjects, and continued at the same dose for the other subject. The mean±SD volume of saline infusion pre‐bypass was 2.6±0.4 L and post‐bypass was 2.3±0.3 L.
Example 2 - Morning Injection ◦Wake up and inject your HGH Frag 176-191 (250mcg to 500mcg is a good dosage depending on your budget). ◦Wait as long as possible before having your first meal (the longer you wait the more fat you will burn). ◦When you do eat, try to make the meal high protein, low fat and low carbohydrate (example meat and salad/vegetables). ◦If possible, try to do some cardio in the hours after your injection to increase the fat burning effect.
The process to get a cream doesn't happen overnight. Explains Smeath: "A patient will complete a comprehensive medical questionnaire, which is sent to one of our prescribing doctors. [They] review all medical notes, make contact with the patient and once approved, send a prescription to one of two TGA-approved compounding pharmacies in Australia who ship [the peptides] directly."
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From this study it appears that the β3-AR is an important contributor to the effects observed on body weight in obese mice treated with AOD9604 and hGH. To determine whether theβ 3-AR is partly responsible for this effect, we examined the effects of AOD9604 and hGH in theβ 3-KO mouse. The β3-KO mouse is not grossly obese, but female mice have increased fat depots (21) and the mice do develop late-onset obesity (Summers, R. J., personal communication). AOD9604 and hGH increased body mass and decreased BAT mass in the WT strain but had no effect in the KO animals. In WT mice, plasma glycerol was increased in response to AOD9604 and hGH treatment (4 wk). However, in the KO mice, only hGH resulted in increased levels of glycerol in the KO mice, and this effect was significantly less than that observed in the WT mice. This suggests that the regulation of the β3-AR is essential in the ability of AOD9604 and hGH to mediate chronic effects on lipolysis and fat mass reduction.
Comparing everything else is hard due to branding... don't want to start going into branding for obvious reasons. GH is incredible for fatloss but some brands add so much water it is hard to see the results to begin with. But due to the high serum and igf-1 from gh excellent results are to be had. Many factors come into play though which I am sure your well aware of. I think the ghrp's (2 and 6 for example) are excellent for fatloss if you keep up with the 4 daily injections in your research. Otherwise they are nowhere as effective due to the short peak times... so one must be organized and disciplined to get the full benefits.
Five patients in the study reported a serious AE; three in the AOD9604 20 mg group (basal cell carcinoma, moderate lipoma and squamous cell carcinoma), one in the 5 mg group (breast cancer) and one in the 10 mg group (malignant melanoma). According to the investigator, none of the SAEs reported were considered to be possibly, probably or definitely related to study medication (see discussion).
LR3 would be great for fatloss. I would use that solo (not with cjcdac or gh)... obviously if you have any clen, t3, eca etc then you could add them in. I have limited experience with lr3 so can't fully comment from my own research. But from what I observed on Bane it is great for fatloss... anything that raises igf-1 should be. But the results from the cjc-dac were superior in every way during my research.
For example, studies have shown that people deficient in IGF-1 have an increased chance of dying from a heart attack. This is because IGF-1 prevents the death of heart cells and offers protection to heart cells when the cells are stressed, such as during a heart attack or long amount of time without oxygen. IGF-1 has a similar protective effect on brain cells.
Lean C57BL/6J and obese (ob/ob) mice aged 12 wk were used in this study. There were 18 mice in each group, and they were divided into three treatment groups [saline (n = 6); AOD (250μ g/kg·d; n = 6); hGH (1 mg/k·d; n = 6)]. The animals were housed in the Departmental Animal Facility at a constant temperature and humidity in a 12-h light, 12-h dark cycle. Animals were injected with a single intraperitoneal dose of saline, AOD9604, or hGH at 0800 h each day for 14 d using a 1-ml syringe and 23-gauge needle. The body weights of the animals were recorded every second day along with food intake.
CJC-1295 is a fast-acting Growth Hormone Releasing Hormone designed to enhance the body’s natural production and release of human growth hormone and Insulin-like Growth Factor 1 (IGF-1). In doing so, CJC-1295 reverses the age-related decline, generates new muscle cells and increases fat loss. Another great trait of CJC-1295 is its ability to promote slow wave sleep, a deep sleep responsible for the highest levels of cell regeneration, muscle growth and memory retention.
There were concerns regarding the number of contraindications and precautions and whether consumers would be able to interpret these appropriately without a requirement for pharmacist advice. There were concerns regarding gastro-intestinal, renal and other adverse effects related to the potential interactions of ibuprofen and paracetamol. Also raised were concerns regarding the potential for paracetamol overdose.
As a athlete, incorporating a growth hormone-like Ipamorelin is extremely beneficial. Not only in the development of lean muscle tissue and muscle mass, but also in the decreased recovery time you are going to experience after each workout. You can workout more, you can workout and lift harder, and you can increase your level of exertion at the gym to experience the greatest gains, as your body is going to heal much faster than it would without the growth hormone.